SCOPe 2.07: Family g.3.11.1: EGF-type module

Lineage for Family g.3.11.1: EGF-type module

1. Root: SCOPe 2.07

2. Class g: Small proteins [56992] (98 folds)

3. Fold g.3: Knottins (small inhibitors, toxins, lectins) [57015] (19 superfamilies)
   disulfide-bound fold; contains beta-hairpin with two adjacent disulfides

4. Superfamily g.3.11: EGF/Laminin [57196] (8 families)

5. Family g.3.11.1: EGF-type module [57197] (23 proteins)

Proteins:

1. Activated protein c (autoprothrombin IIa) [57208] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [57209] (1 PDB entry)

2. Betacellulin-2 [75670] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [75671] (2 PDB entries)

3. Coagulation factor VIIa [57201] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [57202] (97 PDB entries)
     Uniprot P08709 108-202 ! Uniprot P08709 107-202

4. Complement C1S component [90143] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [90144] (3 PDB entries)

5. Complement protease C1R [57229] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [57230] (1 PDB entry)

6. E-selectin, EGF-domain [57203] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [57204] (5 PDB entries)

7. Epidermal growth factor, EGF [57215] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [69939] (5 PDB entries)

   2. Species Mouse (Mus musculus) [TaxId:10090] [57216] (8 PDB entries)

8. Epiregulin, EGF-domain [103561] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [103562] (2 PDB entries)

9. Factor IX (IXa) [57198] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [57199] (29 PDB entries)

   2. Species Pig (Sus scrofa) [TaxId:9823] [57200] (2 PDB entries)

10. Factor X, N-terminal module [57205] (2 species)

    1. Species Cow (Bos taurus) [TaxId:9913] [57207] (5 PDB entries)

    2. Species Human (Homo sapiens) [TaxId:9606] [57206] (85 PDB entries)
       Uniprot P00742 127-178

11. Fibrillin-1 [57227] (1 species)
    duplication: contains 47 EFG-like domains

    • Species Human (Homo sapiens) [TaxId:9606] [57228] (7 PDB entries)

12. Heparin-binding epidermal growth factor, HBEGF [57219] (1 species)
    extracellular domain

    • Species Human (Homo sapiens) [TaxId:9606] [57220] (1 PDB entry)

13. Heregulin-alpha, EGF-like domain [57223] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [57224] (4 PDB entries)

14. Low density lipoprotein (LDL) receptor, different EGF domains [64539] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [64540] (7 PDB entries)
      Uniprot P01130 272-353

15. Mannose-binding protein associated serine protease 2, MASP2 [90141] (2 species)
    EGF-like domain separates two CUB domains

    1. Species Human (Homo sapiens) [TaxId:9606] [111402] (1 PDB entry)
       Uniprot O00187 17-181

    2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [90142] (1 PDB entry)

16. Neurogenic locus notch homolog protein 1, Notch1 [118243] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [118244] (1 PDB entry)
      Uniprot P46531 411-526

17. P-selectin, EGF-domain [57213] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [57214] (1 PDB entry)

18. Plasminogen activator (tissue-type), t-PA [57231] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [57232] (1 PDB entry)

19. Plasminogen activator (urokinase-type) [57221] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [57222] (6 PDB entries)

20. Prostaglandin H2 synthase-1, EGF-like module [57210] (2 species)
    the rest of protein is heme-linked peroxidase, all-alpha fold

    1. Species Mouse (Mus musculus) [TaxId:10090] [57212] (13 PDB entries)

    2. Species Sheep (Ovis aries) [TaxId:9940] [57211] (23 PDB entries)
       Uniprot P05979 32-584

21. Thrombomodulin, different EGF-like domains [57225] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [57226] (6 PDB entries)

22. Transforming growth factor alpha [57217] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [57218] (7 PDB entries)

23. automated matches [190092] (2 species)
    not a true protein

    1. Species Human (Homo sapiens) [TaxId:9606] [187310] (72 PDB entries)

    2. Species Mouse (Mus musculus) [TaxId:10090] [334131] (3 PDB entries)

More info for Family g.3.11.1: EGF-type module

Timeline for Family g.3.11.1: EGF-type module:

• Family g.3.11.1: EGF-type module first appeared (with stable ids) in SCOP 1.55
  
• Family g.3.11.1: EGF-type module appears in SCOPe 2.06
  
• Family g.3.11.1: EGF-type module appears in the current release, SCOPe 2.08