SCOP 1.69: Family g.3.9.1: Growth factor receptor domain

Lineage for Family g.3.9.1: Growth factor receptor domain

1. Root: SCOP 1.69

2. Class g: Small proteins [56992] (75 folds)

3. Fold g.3: Knottins (small inhibitors, toxins, lectins) [57015] (19 superfamilies)
   disulfide-bound fold; contains beta-hairpin with two adjacent disulfides

4. Superfamily g.3.9: Growth factor receptor domain [57184] (1 family)

5. Family g.3.9.1: Growth factor receptor domain [57185] (5 proteins)

Proteins:

1. EGF receptor Cys-rich domains [82887] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [82888] (3 PDB entries)

2. Insulin-like growth factor-binding protein-5 (IGFBP-5) [57186] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [57187] (2 PDB entries)

3. Protooncoprotein Her2 extracellular domain [82889] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [82890] (2 PDB entries)

   2. Species Rat (Rattus norvegicus) [TaxId:10116] [82891] (1 PDB entry)

4. Receptor protein-tyrosine kinase Erbb-3 Cys-rich domains [75668] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [75669] (1 PDB entry)

5. Type 1 insulin-like growth factor receptor Cys-rich domain [57188] (1 species)
   contains 3 cystine-knot subdomains and 4 single-disulfide cystine knot-like subdomains

   • Species Human (Homo sapiens) [TaxId:9606] [57189] (1 PDB entry)

More info for Family g.3.9.1: Growth factor receptor domain

Timeline for Family g.3.9.1: Growth factor receptor domain:

• Family g.3.9.1: Growth factor receptor domain first appeared (with stable ids) in SCOP 1.55, called Family g.3.9.1: IGF binding domain
  
• Family g.3.9.1: Growth factor receptor domain appears in SCOP 1.67
  
• Family g.3.9.1: Growth factor receptor domain appears in SCOP 1.71
  
• Family g.3.9.1: Growth factor receptor domain appears in the current release, SCOPe 2.08