SCOPe 2.08: Family g.3.9.1: Growth factor receptor domain

Lineage for Family g.3.9.1: Growth factor receptor domain

1. Root: SCOPe 2.08

2. Class g: Small proteins [56992] (100 folds)

3. Fold g.3: Knottins (small inhibitors, toxins, lectins) [57015] (19 superfamilies)
   disulfide-bound fold; contains beta-hairpin with two adjacent disulfides

4. Superfamily g.3.9: Growth factor receptor domain [57184] (2 families)

5. Family g.3.9.1: Growth factor receptor domain [57185] (11 proteins)
   Pfam PF00757; Pfam PF14843; Pfam PF15913
   heterogeneous fold; applies to domains that adopt a different fold than the exemplar domain but has similar sequence and number of secondary structures
   

Proteins:

1. EGF receptor Cys-rich domains, C-terminal domain [419057] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [419548] (5 PDB entries)

2. EGF receptor Cys-rich domains, N-terminal domain [419056] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [419547] (4 PDB entries)

3. Insulin receptor [161122] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [161123] (1 PDB entry)
     Uniprot P06213 184-338

4. Insulin-like growth factor-binding protein 4 [161120] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [161121] (1 PDB entry)
     Uniprot P22692 24-103

5. Insulin-like growth factor-binding protein 4, IGFBP4 [161124] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [161125] (1 PDB entry)
     Uniprot P22692 22-113

6. Insulin-like growth factor-binding protein-5 (IGFBP-5) [57186] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [57187] (2 PDB entries)

7. Protooncoprotein Her2 extracellular domain [82889] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [82890] (2 PDB entries)

   2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [82891] (1 PDB entry)

8. Receptor protein-tyrosine kinase Erbb-3 Cys-rich domains [75668] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [75669] (1 PDB entry)

9. Stem cell growth factor R-spondin-1 (Rspo1) Furin (Fu1Fu2) domain [310761] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [311016] (2 PDB entries)

10. Type 1 insulin-like growth factor receptor Cys-rich domain [57188] (1 species)
    contains 3 cystine-knot subdomains and 4 single-disulfide cystine knot-like subdomains

    • Species Human (Homo sapiens) [TaxId:9606] [57189] (1 PDB entry)

11. automated matches [190609] (1 species)
    not a true protein

    • Species Human (Homo sapiens) [TaxId:9606] [187631] (7 PDB entries)

More info for Family g.3.9.1: Growth factor receptor domain

Timeline for Family g.3.9.1: Growth factor receptor domain:

• Family g.3.9.1: Growth factor receptor domain first appeared (with stable ids) in SCOP 1.55, called Family g.3.9.1: IGF binding domain
  
• Family g.3.9.1: Growth factor receptor domain appears in SCOPe 2.07