Lineage for Class f: Membrane and cell surface proteins and peptides

  1. Root: SCOP 1.63
  2. 267451Class f: Membrane and cell surface proteins and peptides [56835] (34 folds)

Folds:

  1. 267452f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
    multi-helical domains of various folds which is thought to unfold in the membrane
  2. 267520f.3: Light-harvesting complex subunits [56917] (1 superfamily)
    membrane all-alpha fold
  3. 267556f.4: Transmembrane beta-barrels [56924] (4 superfamilies)
    not a true fold, gathers together transmembrane barrels of different (n,S)
  4. 267685f.5: Integral outer membrane protein TolC, efflux pump component [56953] (1 superfamily)
    subunit fold contains tandem repeat of alpha-beta hairpin-alpha(2) motif
    trimeric fold contains barrel (n=12, S=18) formed by beta-hairins, two from each subunit, and a bundle of helices with a channel running through it
  5. 267693f.6: Leukocidin (pore-forming toxin) [56958] (1 superfamily)
    subunit fold contains beta-sandwich of Ig-like (grek-key) topology
    heptameric fold contains barrel (n=14, S=14) formed by beta-ribbon arms, one from each subunit
  6. 267713f.7: Lipovitellin-phosvitin complex; beta-sheet shell regions [56967] (1 superfamily)
  7. 267721f.8: (Pro)aerolysin, pore-forming lobe [56972] (1 superfamily)
    3 domains: (1) alpha+beta; (2&3) all-beta
  8. 267728f.9: Perfringolysin [56977] (1 superfamily)
    2 domains: (1) alpha+beta; (2) all-beta, similar to the CalB domain fold but the two last strands are transposed
  9. 267734f.10: Viral glycoprotein, central and dimerisation domains [56982] (1 superfamily)
    2 intertwined domains; all-beta and alpha+beta
  10. 267743f.11: Anthrax protective antigen [56987] (1 superfamily)
    4 domains; I (res. 14-225) and II (226-487) are beta-sandwiches of similar gamma-crystallin like topologies; III (488-594) has a beta-grasp like fold; IV (595-735) has an Ig-like fold
  11. 267749f.12: Head and neck region of the ectodomain of NDV fusion glycoprotein [69921] (1 superfamily)
    3 intertwined all-beta domains
  12. 267760f.13: Family A G protein-coupled receptor-like [81322] (1 superfamily)
    core: up-and-down bundle of seven transmembrane helices tilted 20 degrees with respect to the plane of the membrane
  13. 267828f.14: Voltage-gated potassium channels [81325] (1 superfamily)
    oligomeric transmembrane alpha-helical proteins
  14. 267869f.15: Small-conductance potassium channel [81328] (1 superfamily)
    oligomeric transmembrane alpha-helical protein
  15. 267876f.16: Gated mechanosensitive channel [81331] (1 superfamily)
    oligomeric transmembrane alpha-helical protein
  16. 267886f.17: Transmembrane helix hairpin [81334] (2 superfamilies)
    two antiparallel transmembrane helices
  17. 267936f.18: F1F0 ATP synthase subunit A [81337] (1 superfamily)
    core: up-and-down bundle of four transmembrane helices
  18. 267942f.19: Aquaporin-like [81339] (1 superfamily)
    core: 8 helices, 2 short helices are surrounded by 6 long transmembrane helices
  19. 267958f.20: Clc chloride channel [81341] (1 superfamily)
    core: 18 transmembrane helices
  20. 267974f.21: Heme-binding four-helical bundle [81344] (2 superfamilies)
    core: four transmembrane helices, up-and-down bundle, binds one or two heme groups in between the helices
  21. 268034f.22: ABC transporter involved in vitamin B12 uptake, BtuC [81346] (1 superfamily)
    multihelical; complex architecture with several transmembrane helices
  22. 268041f.23: Single transmembrane helix [81407] (22 superfamilies)
    not a true fold
  23. 268317f.24: Cytochrome c oxidase subunit I-like [81443] (1 superfamily)
    12 transmembrane helices in an approximate threefold rotational symmetric arrangement
  24. 268348f.25: Cytochrome c oxidase subunit III-like [81453] (1 superfamily)
    core: 7 transmembrane helices organised into two bundles, one formed by the first two helices and the other by the rest
  25. 268375f.26: Bacterial photosystem II reaction centre, L and M subunits [81484] (1 superfamily)
    five transmembrane helices forming a sheet-like structure
  26. 268474f.27: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) [81525] (1 superfamily)
    membrane-associated alpha-helical protein; no transmembrane helices
  27. 268492f.28: Nonheme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) [81532] (1 superfamily)
    membrane-associated alpha-helical protein; no transmembrane helices
  28. 268510f.29: Photosystem I subunits PsaA/PsaB [81559] (1 superfamily)
    core:11 transmembrane helices
  29. 268519f.30: Photosystem I reaction center subunit X, PsaK [81564] (1 superfamily)
    core: hairpin of two transmembrane helices
  30. 268525f.31: Photosystem I reaction center subunit XI, PsaL [81569] (1 superfamily)
    core: three transmembrane helices, bundle
  31. 268531f.32: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) [81649] (1 superfamily)
    core: three transmembrane helices, up-and-down bundle
  32. 268549f.33: Calcium ATPase, transmembrane domain M [81666] (1 superfamily)
    core: multihelical; consists of three transmembrane regions of 2, 2 and 6 helices, separated by cytoplasmic domains
  33. 268558f.34: Mechanosensitive channel protein MscS (YggB), transmembrane region [82860] (1 superfamily)
    oligomeric fold; 3 transmembrane helices per subunit
  34. 268570f.35: Multidrug efflux transporter AcrB transmembrane domain [82865] (1 superfamily)
    12 transmembrane helices; duplication: the N- and C-terminal halves of the whole proteins are structurally similar

More info for Class f: Membrane and cell surface proteins and peptides

Timeline for Class f: Membrane and cell surface proteins and peptides: