SCOPe 2.06: Family e.8.1.2: Reverse transcriptase

Lineage for Family e.8.1.2: Reverse transcriptase

1. Root: SCOPe 2.06

2. Class e: Multi-domain proteins (alpha and beta) [56572] (69 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (3 proteins)

Proteins:

1. HIV-1 reverse transcriptase [56689] (4 species)

   1. Species Hiv-1 m:b_hxb2r [TaxId:11706] [190022] (22 PDB entries)

   2. Species Human immunodeficiency virus type 1 group m subtype b (isolate lw123) [TaxId:82834] [319106] (1 PDB entry)

   3. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (172 PDB entries)
      Uniprot P04585 159-692 # chain A coverage; chain B is shorter: 162-582 ! Uniprot P03366 186-725 # chain A coverage; chain B coverage: 156-584 ! Uniprot P04585 158-698 # chain A coverage; chain B is shorter: 159-595

   4. Species Human immunodeficiency virus type 2 [TaxId:11709] [82840] (1 PDB entry)

2. MMLV reverse transcriptase [56687] (1 species)

   • Species Moloney murine leukemia virus, MoMLV [TaxId:11801] [56688] (22 PDB entries)
     Uniprot P03355 RE 144-594

3. automated matches [190211] (6 species)
   not a true protein

   1. Species Hiv-1 m:b_hxb2r [TaxId:11706] [187165] (10 PDB entries)

   2. Species Human immunodeficiency virus 1 [TaxId:11676] [186967] (7 PDB entries)

   3. Species Human immunodeficiency virus type 1 bh10 [TaxId:11678] [225820] (18 PDB entries)

   4. Species Human immunodeficiency virus type 1 group m subtype b (isolate bh10) [TaxId:11678] [311492] (2 PDB entries)

   5. Species Human immunodeficiency virus type 1 [TaxId:11678] [226272] (13 PDB entries)

   6. Species Moloney murine leukemia virus [TaxId:11801] [188900] (1 PDB entry)

More info for Family e.8.1.2: Reverse transcriptase

Timeline for Family e.8.1.2: Reverse transcriptase:

• Family e.8.1.2: Reverse transcriptase first appeared (with stable ids) in SCOP 1.55
  
• Family e.8.1.2: Reverse transcriptase appears in SCOPe 2.05
  
• Family e.8.1.2: Reverse transcriptase appears in SCOPe 2.07
  
• Family e.8.1.2: Reverse transcriptase appears in the current release, SCOPe 2.08