Lineage for Protein: beta-Lactamase, class A

  1. Root: SCOPe 2.06
  2. 2243857Class e: Multi-domain proteins (alpha and beta) [56572] (69 folds)
  3. 2244155Fold e.3: beta-lactamase/transpeptidase-like [56600] (1 superfamily)
    contains a cluster of helices and an alpha+beta sandwich
  4. 2244156Superfamily e.3.1: beta-lactamase/transpeptidase-like [56601] (4 families) (S)
  5. 2244157Family e.3.1.1: beta-Lactamase/D-ala carboxypeptidase [56602] (19 proteins)
  6. 2244418Protein beta-Lactamase, class A [56606] (16 species)

Species:

  1. 2244419Bacillus licheniformis [TaxId:1402] [56612] (14 PDB entries)
    1. Domains for 1i2s:
      1. 2244420Domain d1i2sa_: 1i2s A: [71104]
        complexed with cit, na
      2. 2244421Domain d1i2sb_: 1i2s B: [71105]
        complexed with cit, na
    2. Domains for 1i2w:
      1. 2244422Domain d1i2wa_: 1i2w A: [71106]
        complexed with cfx, out
      2. 2244423Domain d1i2wb_: 1i2w B: [71107]
        complexed with cfx, out
    3. Domains for 1mbl:
      1. 2244434Domain d1mbla_: 1mbl A: [42723]
        complexed with so4; mutant
      2. 2244435Domain d1mblb_: 1mbl B: [42724]
        complexed with so4; mutant
    4. Domains for 2blm:
      1. 2244438Domain d2blma_: 2blm A: [42725]
        CA-atoms only
      2. 2244439Domain d2blmb_: 2blm B: [42726]
        CA-atoms only
    5. Domains for 3kgm:
      1. 2244442Domain d3kgma_: 3kgm A: [305696]
        automated match to d3ly3a_
        complexed with bb0
      2. 2244443Domain d3kgmb_: 3kgm B: [305697]
        automated match to d3ly3a_
        complexed with bb0
    6. Domains for 3kgn:
      1. 2244444Domain d3kgna_: 3kgn A: [305698]
        automated match to d3ly3a_
        complexed with bb0, pcz, so4
      2. 2244445Domain d3kgnb_: 3kgn B: [305699]
        automated match to d3ly3a_
        complexed with bb0, pcz, so4
    7. Domains for 3kgo:
      1. 2244432Domain d3kgoa_: 3kgo A: [305700]
        automated match to d3ly3a_
        complexed with ced
      2. 2244433Domain d3kgob_: 3kgo B: [305701]
        automated match to d3ly3a_
        complexed with ced
    8. Domain for 3ly3:
    9. Domain for 3ly4:
    10. Domains for 3m2j:
      1. 2244425Domain d3m2ja_: 3m2j A: [180745]
        automated match to d1mbla_
        complexed with f5m, so4
      2. 2244426Domain d3m2jb_: 3m2j B: [180746]
        automated match to d1mbla_
        complexed with f5m, so4
    11. Domains for 3sh7:
      1. 2244440Domain d3sh7a_: 3sh7 A: [197443]
        automated match to d3ly3a_
        complexed with bb0
      2. 2244441Domain d3sh7b_: 3sh7 B: [193681]
        automated match to d3ly3a_
        complexed with bb0
    12. Domains for 3sh8:
      1. 2244436Domain d3sh8a_: 3sh8 A: [185375]
        automated match to d2blma_
        complexed with ced
      2. 2244437Domain d3sh8b_: 3sh8 B: [185376]
        automated match to d2blma_
        complexed with ced
    13. Domains for 3sh9:
      1. 2244427Domain d3sh9a_: 3sh9 A: [216414]
        automated match to d3sh8a_
        complexed with bb0, pcz
      2. 2244428Domain d3sh9b_: 3sh9 B: [216415]
        automated match to d3sh8a_
        complexed with bb0, pcz
    14. Domains for 4blm:
      1. 2244429Domain d4blma_: 4blm A: [42721]
        complexed with so4
      2. 2244430Domain d4blmb_: 4blm B: [42722]
        complexed with so4
  2. 2244446Enterobacter cloacae, NMC-A carbapenemase [TaxId:550] [56613] (2 PDB entries)
    1. Domain for 1bue:
    2. Domain for 1bul:
  3. 2244449Escherichia coli, TEM-1 [TaxId:562] [56607] (59 PDB entries)
    1. Domain for 1axb:
    2. Domain for 1bt5:
    3. Domain for 1btl:
    4. Domain for 1ck3:
    5. Domain for 1erm:
    6. Domain for 1ero:
    7. Domain for 1erq:
    8. Domain for 1esu:
    9. Domain for 1fqg:
    10. Domain for 1jtd:
    11. Domains for 1jtg:
      1. 2244465Domain d1jtga_: 1jtg A: [67266]
        Other proteins in same PDB: d1jtgb_, d1jtgd_
        complexed with ca
      2. 2244466Domain d1jtgc_: 1jtg C: [67268]
        Other proteins in same PDB: d1jtgb_, d1jtgd_
        complexed with ca
    12. Domain for 1jvj:
    13. Domain for 1jwp:
    14. Domain for 1jwv:
    15. Domain for 1jwz:
    16. Domain for 1lhy:
    17. Domain for 1li0:
    18. Domain for 1li9:
    19. Domain for 1m40:
      • 2244450Domain d1m40a_: 1m40 A: [74437]
        ultra high resolution structure
        complexed with cb4, k, po4
    20. Domain for 1nxy:
    21. Domain for 1ny0:
    22. Domain for 1nym:
    23. Domain for 1nyy:
    24. Domain for 1pzo:
    25. Domain for 1pzp:
    26. Domains for 1s0w:
      1. 2244525Domain d1s0wa_: 1s0w A: [98309]
        Other proteins in same PDB: d1s0wc_, d1s0wd_
        complexed with ca
      2. 2244526Domain d1s0wb_: 1s0w B: [98310]
        Other proteins in same PDB: d1s0wc_, d1s0wd_
        complexed with ca
    27. Domain for 1tem:
    28. Domain for 1xpb:
    29. Domains for 1xxm:
      1. 2244495Domain d1xxma_: 1xxm A: [162118]
        Other proteins in same PDB: d1xxmc_, d1xxmd_
        automated match to d1axba_
        complexed with ca
      2. 2244496Domain d1xxmb_: 1xxm B: [162119]
        Other proteins in same PDB: d1xxmc_, d1xxmd_
        automated match to d1axba_
        complexed with ca
    30. Domain for 1yt4:
    31. Domain for 1zg4:
    32. Domain for 1zg6:
    33. Domains for 2b5r:
      1. 2244461Domain d2b5ra1: 2b5r A:26-288 [144952]
        Other proteins in same PDB: d2b5rc_, d2b5rd_
      2. 2244462Domain d2b5rb_: 2b5r B: [144953]
        Other proteins in same PDB: d2b5rc_, d2b5rd_
        automated match to d2b5ra1
    34. Domains for 3c7u:
      1. 2244519Domain d3c7ua_: 3c7u A: [156017]
        Other proteins in same PDB: d3c7ub_, d3c7ud_
        automated match to d1axba_
      2. 2244520Domain d3c7uc_: 3c7u C: [156018]
        Other proteins in same PDB: d3c7ub_, d3c7ud_
        automated match to d1axba_
    35. Domains for 3c7v:
      1. 2244504Domain d3c7va_: 3c7v A: [156019]
        Other proteins in same PDB: d3c7vb_, d3c7vd_
        automated match to d1axba_
      2. 2244505Domain d3c7vc_: 3c7v C: [156020]
        Other proteins in same PDB: d3c7vb_, d3c7vd_
        automated match to d1axba_
    36. Domain for 3cmz:
    37. Domains for 3toi:
      1. 2244489Domain d3toia1: 3toi A:41-287 [216914]
        Other proteins in same PDB: d3toia2, d3toia3, d3toib2
        automated match to d1omeb_
      2. 2244490Domain d3toib1: 3toi B:42-287 [216915]
        Other proteins in same PDB: d3toia2, d3toia3, d3toib2
        automated match to d1omeb_
    38. Domain for 4gku:
    39. Domains for 4ibx:
      1. 2244538Domain d4ibxa_: 4ibx A: [202603]
        automated match to d4ibxb_
        complexed with ca, mes, so4
      2. 2244539Domain d4ibxb_: 4ibx B: [196860]
        automated match to d1zg4a1
        complexed with ca, mes, so4
      3. 2244540Domain d4ibxc_: 4ibx C: [202604]
        automated match to d4ibxb_
        complexed with ca, mes, so4
      4. 2244541Domain d4ibxd_: 4ibx D: [202605]
        automated match to d4ibxb_
        complexed with ca, mes, so4
      5. 2244542Domain d4ibxe_: 4ibx E: [202606]
        automated match to d4ibxb_
        complexed with ca, mes, so4
    40. Domains for 4mez:
      1. 2244527Domain d4meza_: 4mez A: [260322]
        automated match to d1li9a_
        complexed with cl, gol, so4; mutant
      2. 2244528Domain d4mezb_: 4mez B: [263012]
        automated match to d4meza_
        complexed with cl, gol, so4; mutant
    41. Domain for 4op5:
    42. Domain for 4opy:
    43. Domains for 4oqg:
      1. 2244551Domain d4oqga_: 4oqg A: [272872]
        automated match to d1btla_
        complexed with 2ul, zn
      2. 2244552Domain d4oqgb_: 4oqg B: [272873]
        automated match to d1btla_
        complexed with 2ul, zn
      3. 2244553Domain d4oqgc_: 4oqg C: [272875]
        automated match to d1btla_
        complexed with 2ul, zn
      4. 2244554Domain d4oqgd_: 4oqg D: [272876]
        automated match to d1btla_
        complexed with 2ul, zn
      5. 2244555Domain d4oqge_: 4oqg E: [272877]
        automated match to d1btla_
        complexed with 2ul, zn
      6. 2244556Domain d4oqgf_: 4oqg F: [272878]
        automated match to d1btla_
        complexed with 2ul, zn
    44. Domain for 4oqh:
    45. Domain for 4rva:
    46. Domains for 4rx2:
      1. 2244543Domain d4rx2a_: 4rx2 A: [269876]
        automated match to d1fqga_
        complexed with so4; mutant
      2. 2244544Domain d4rx2b_: 4rx2 B: [269877]
        automated match to d1fqga_
        complexed with so4; mutant
      3. 2244545Domain d4rx2c_: 4rx2 C: [269880]
        automated match to d1fqga_
        complexed with so4; mutant
      4. 2244546Domain d4rx2d_: 4rx2 D: [269879]
        automated match to d1fqga_
        complexed with so4; mutant
      5. 2244547Domain d4rx2e_: 4rx2 E: [269882]
        automated match to d1fqga_
        complexed with so4; mutant
      6. 2244548Domain d4rx2f_: 4rx2 F: [269881]
        automated match to d1fqga_
        complexed with so4; mutant
      7. 2244549Domain d4rx2g_: 4rx2 G: [269884]
        automated match to d1fqga_
        complexed with so4; mutant
      8. 2244550Domain d4rx2h_: 4rx2 H: [269883]
        automated match to d1fqga_
        complexed with so4; mutant
    47. Domain for 4rx3:
    48. Domain for 4zj1:
    49. Domain for 4zj2:
    50. Domain for 4zj3:
    51. Domains for 5hvi:
      1. 2244497Domain d5hvia_: 5hvi A: [335986]
        automated match to d1m40a_
      2. 2244498Domain d5hvib_: 5hvi B: [335971]
        automated match to d1m40a_
      3. 2244499Domain d5hvic_: 5hvi C: [336009]
        automated match to d1m40a_
      4. 2244500Domain d5hvid_: 5hvi D: [335963]
        automated match to d1m40a_
    52. Domains for 5hw1:
      1. 2244506Domain d5hw1a_: 5hw1 A: [336088]
        automated match to d1m40a_
        complexed with xe
      2. 2244507Domain d5hw1b_: 5hw1 B: [336038]
        automated match to d1m40a_
        complexed with xe
      3. 2244508Domain d5hw1c_: 5hw1 C: [336065]
        automated match to d1m40a_
        complexed with xe
      4. 2244509Domain d5hw1d_: 5hw1 D: [336089]
        automated match to d1m40a_
        complexed with xe
    53. Domains for 5hw5:
      1. 2244472Domain d5hw5a_: 5hw5 A: [335975]
        automated match to d1m40a_
        complexed with xe
      2. 2244473Domain d5hw5b_: 5hw5 B: [336157]
        automated match to d1m40a_
        complexed with xe
      3. 2244474Domain d5hw5c_: 5hw5 C: [336026]
        automated match to d1m40a_
        complexed with xe
      4. 2244475Domain d5hw5d_: 5hw5 D: [336055]
        automated match to d1m40a_
        complexed with xe
    54. Domains for 5i52:
      1. 2244513Domain d5i52a_: 5i52 A: [335964]
        automated match to d1erma_
        mutant
      2. 2244514Domain d5i52b_: 5i52 B: [336022]
        automated match to d1erma_
        mutant
      3. 2244515Domain d5i52c_: 5i52 C: [335967]
        automated match to d1erma_
        mutant
      4. 2244516Domain d5i52d_: 5i52 D: [335968]
        automated match to d1erma_
        mutant
    55. Domains for 5i63:
      1. 2244529Domain d5i63a_: 5i63 A: [336021]
        automated match to d1erma_
        complexed with xe; mutant
      2. 2244530Domain d5i63b_: 5i63 B: [335965]
        automated match to d1erma_
        complexed with xe; mutant
      3. 2244531Domain d5i63c_: 5i63 C: [336010]
        automated match to d1erma_
        complexed with xe; mutant
      4. 2244532Domain d5i63d_: 5i63 D: [335983]
        automated match to d1erma_
        complexed with xe; mutant
    56. Domains for 5iq8:
      1. 2244534Domain d5iq8a_: 5iq8 A: [335995]
        automated match to d1erma_
        mutant
      2. 2244535Domain d5iq8b_: 5iq8 B: [336083]
        automated match to d1erma_
        mutant
      3. 2244536Domain d5iq8c_: 5iq8 C: [335966]
        automated match to d1erma_
        mutant
      4. 2244537Domain d5iq8d_: 5iq8 D: [336076]
        automated match to d1erma_
        mutant
    57. Domains for 5kkf:
      1. 2244521Domain d5kkfa_: 5kkf A: [336387]
        automated match to d1erma_
        mutant
      2. 2244522Domain d5kkfb_: 5kkf B: [336342]
        automated match to d1erma_
        mutant
      3. 2244523Domain d5kkfc_: 5kkf C: [336401]
        automated match to d1erma_
        mutant
      4. 2244524Domain d5kkfd_: 5kkf D: [336413]
        automated match to d1erma_
        mutant
    58. Domains for 5kpu:
      1. 2244481Domain d5kpua_: 5kpu A: [337495]
        automated match to d1erma_
        complexed with xe; mutant
      2. 2244482Domain d5kpub_: 5kpu B: [337557]
        automated match to d1erma_
        complexed with xe; mutant
      3. 2244483Domain d5kpuc_: 5kpu C: [337511]
        automated match to d1erma_
        complexed with xe; mutant
      4. 2244484Domain d5kpud_: 5kpu D: [337531]
        automated match to d1erma_
        complexed with xe; mutant
    59. Domain for 5npo:
  4. 2244557Escherichia coli, TOHO-1 [TaxId:562] [56608] (26 PDB entries)
    1. Domain for 1bza:
    2. Domain for 1iyo:
    3. Domain for 1iyp:
    4. Domain for 1iyq:
    5. Domain for 1iys:
    6. Domain for 1we4:
    7. Domain for 2wyx:
    8. Domain for 2xqz:
    9. Domain for 2xr0:
    10. Domain for 2zq7:
    11. Domain for 2zq8:
    12. Domain for 2zq9:
    13. Domain for 2zqa:
    14. Domain for 2zqc:
    15. Domain for 2zqd:
    16. Domain for 4bd0:
    17. Domain for 4bd1:
    18. Domain for 4c3q:
    19. Domains for 4x69:
      1. 2244571Domain d4x69a_: 4x69 A: [274549]
        automated match to d1iysa_
        complexed with edo, op0
      2. 2244572Domain d4x69b_: 4x69 B: [274548]
        automated match to d1iysa_
        complexed with edo, op0
    20. Domain for 5a90:
    21. Domain for 5a91:
    22. Domain for 5a92:
    23. Domain for 5a93:
    24. Domain for 5g18:
    25. Domain for 5kmw:
    26. Domain for 5ksc:
  5. 2244585Klebsiella pneumoniae [TaxId:573] [225597] (9 PDB entries)
    1. Domain for 3d4f:
    2. Domain for 3oph:
    3. Domain for 3opl:
    4. Domain for 3opp:
    5. Domain for 3opr:
    6. Domain for 4gd6:
    7. Domain for 4gd8:
    8. Domain for 4gdb:
    9. Domain for 4jpm:
  6. 2244595Klebsiella pneumoniae, SHV-1 [TaxId:573] [56609] (27 PDB entries)
    inhibited by tazobactam
    Uniprot Q5PSW7 ! Uniprot P14557 22-286
    1. Domain for 1g56:
    2. Domain for 1ong:
    3. Domain for 1q2p:
    4. Domain for 1rcj:
    5. Domain for 1shv:
    6. Domain for 1tdg:
    7. Domain for 1tdl:
    8. Domain for 1vm1:
    9. Domain for 2a3u:
    10. Domain for 2a49:
    11. Domain for 2g2w:
    12. Domain for 2h0t:
    13. Domain for 2h0y:
    14. Domain for 2h10:
    15. Domain for 3n4i:
    16. Domain for 3v50:
    17. Domain for 3v5m:
    18. Domain for 4fcf:
    19. Domain for 4fd8:
    20. Domain for 4fh2:
    21. Domain for 4fh4:
    22. Domain for 4mbf:
    23. Domain for 4mbh:
    24. Domain for 4mbk:
    25. Domain for 4r3b:
    26. Domain for 4zam:
    27. Domain for 5ee8:
  7. 2244623Klebsiella pneumoniae, SHV-2 [TaxId:573] [90082] (10 PDB entries)
    almost identical sequence to SHV-1
    1. Domain for 1n9b:
    2. Domain for 2g2u:
    3. Domain for 2h5s:
    4. Domain for 2zd8:
    5. Domain for 3c4o:
    6. Domain for 3c4p:
    7. Domain for 3mke:
    8. Domain for 3mkf:
    9. Domain for 3mxr:
    10. Domain for 3mxs:
  8. 2244634Klebsiella pneumoniae, TEM52 [TaxId:573] [64473] (1 PDB entry)
  9. 2244641Mycobacterium fortuitum [TaxId:1766] [56615] (2 PDB entries)
    1. Domain for 1mfo:
    2. Domain for 2cc1:
  10. 2244644Proteus vulgaris [TaxId:585] [75596] (1 PDB entry)
  11. 2244647Pseudomonas aeruginosa, PER-1 [TaxId:287] [56616] (1 PDB entry)
  12. 2244649Pseudomonas aeruginosa, PSE-4 carbenicillinase [TaxId:287] [56610] (2 PDB entries)
    1. Domain for 1g68:
    2. Domain for 1g6a:
  13. 2244652Serratia marcescens, Sme-1 [TaxId:615] [56617] (1 PDB entry)
    imipenem-hydrolyzing
  14. 2244655Staphylococcus aureus [TaxId:1280] [56611] (16 PDB entries)
    1. Domain for 1alq:
    2. Domain for 1blc:
    3. Domain for 1blh:
    4. Domain for 1blp:
    5. Domain for 1dja:
    6. Domain for 1djb:
    7. Domain for 1djc:
    8. Domain for 1ghi:
    9. Domain for 1ghm:
    10. Domain for 1ghp:
    11. Domain for 1kge:
    12. Domain for 1kgf:
    13. Domain for 1kgg:
    14. Domains for 1ome:
      1. 2244671Domain d1omea_: 1ome A: [42717]
        omega loop deletion mutant (residues 163-178 deleted)
        complexed with cl; mutant
      2. 2244672Domain d1omeb_: 1ome B: [42718]
        omega loop deletion mutant (residues 163-178 deleted)
        complexed with cl; mutant
    15. Domains for 1pio:
      1. 2244669Domain d1pioa_: 1pio A: [42719]
      2. 2244670Domain d1piob_: 1pio B: [42720]
    16. Domain for 3blm:
  15. 2244674Stenotrophomonas maltophilia, L2 [TaxId:40324] [103374] (2 PDB entries)
    1. Domains for 1n4o:
      1. 2244677Domain d1n4oa_: 1n4o A: [91621]
        complexed with so4
      2. 2244678Domain d1n4ob_: 1n4o B: [91622]
        complexed with so4
    2. Domains for 1o7e:
      1. 2244675Domain d1o7ea_: 1o7e A: [92622]
        complexed with gol, so4
      2. 2244676Domain d1o7eb_: 1o7e B: [92623]
        complexed with gol, so4
  16. 2244679Streptomyces albus G [TaxId:1962] [56614] (1 PDB entry)

More info for Protein beta-Lactamase, class A from e.3.1.1: beta-Lactamase/D-ala carboxypeptidase

Timeline for Protein beta-Lactamase, class A from e.3.1.1: beta-Lactamase/D-ala carboxypeptidase: