Lineage for Family e.3.1.1: beta-Lactamase/D-ala carboxypeptidase

  1. Root: SCOPe 2.04
  2. 1689992Class e: Multi-domain proteins (alpha and beta) [56572] (68 folds)
  3. 1690252Fold e.3: beta-lactamase/transpeptidase-like [56600] (1 superfamily)
    contains a cluster of helices and an alpha+beta sandwich
  4. 1690253Superfamily e.3.1: beta-lactamase/transpeptidase-like [56601] (4 families) (S)
  5. 1690254Family e.3.1.1: beta-Lactamase/D-ala carboxypeptidase [56602] (19 proteins)

Proteins:

  1. 16902556-aminohexanoate-dimer hydrolase NylC [160972] (1 species)
    NylB'
  2. 1690268AMPC beta-Lactamase, class C [56618] (3 species)
    contains small alpha+beta subdomain inserted in the common fold
    1. 1690269Species Citrobacter freundii [TaxId:546] [56619] (3 PDB entries)
    2. 1690275Species Enterobacter cloacae, P99, cephalosporinase [TaxId:550] [56620] (9 PDB entries)
      Uniprot P05364 22-380 ! Uniprot P05364 22-381
    3. 1690287Species Escherichia coli, cephalosporinase [TaxId:562] [56621] (95 PDB entries)
  3. 1690477beta-Lactamase, class A [56606] (16 species)
    1. 1690478Species Bacillus licheniformis [TaxId:1402] [56612] (11 PDB entries)
    2. 1690499Species Enterobacter cloacae, NMC-A carbapenemase [TaxId:550] [56613] (2 PDB entries)
    3. 1690502Species Escherichia coli, TEM-1 [TaxId:562] [56607] (37 PDB entries)
    4. 1690548Species Escherichia coli, TOHO-1 [TaxId:562] [56608] (18 PDB entries)
    5. 1690567Species Klebsiella pneumoniae [TaxId:573] [225597] (9 PDB entries)
    6. 1690577Species Klebsiella pneumoniae, SHV-1 [TaxId:573] [56609] (23 PDB entries)
      inhibited by tazobactam
      Uniprot Q5PSW7 ! Uniprot P14557 22-286
    7. 1690601Species Klebsiella pneumoniae, SHV-2 [TaxId:573] [90082] (10 PDB entries)
      almost identical sequence to SHV-1
    8. 1690612Species Klebsiella pneumoniae, TEM52 [TaxId:573] [64473] (1 PDB entry)
    9. 1690619Species Mycobacterium fortuitum [TaxId:1766] [56615] (1 PDB entry)
    10. 1690621Species Proteus vulgaris [TaxId:585] [75596] (1 PDB entry)
    11. 1690624Species Pseudomonas aeruginosa, PER-1 [TaxId:287] [56616] (1 PDB entry)
    12. 1690626Species Pseudomonas aeruginosa, PSE-4 carbenicillinase [TaxId:287] [56610] (2 PDB entries)
    13. 1690629Species Serratia marcescens, Sme-1 [TaxId:615] [56617] (1 PDB entry)
      imipenem-hydrolyzing
    14. 1690632Species Staphylococcus aureus [TaxId:1280] [56611] (16 PDB entries)
    15. 1690651Species Stenotrophomonas maltophilia, L2 [TaxId:40324] [103374] (2 PDB entries)
    16. 1690656Species Streptomyces albus G [TaxId:1962] [56614] (1 PDB entry)
  4. 1690658Class D beta-lactamase [56622] (4 species)
    1. 1690659Species Escherichia coli, OXA-1 [TaxId:562] [82837] (3 PDB entries)
    2. 1690668Species Pseudomonas aeruginosa, OXA-10 [TaxId:287] [56623] (25 PDB entries)
    3. 1690737Species Pseudomonas aeruginosa, OXA-13 [TaxId:287] [64474] (3 PDB entries)
    4. 1690744Species Salmonella typhimurium, OXA-2 [TaxId:90371] [90083] (1 PDB entry)
  5. 1690747D,D-carboxypeptidase DacA, N-terminal domain [118181] (1 species)
  6. 1690753D-ala carboxypeptidase/transpeptidase [56603] (2 species)
    1. 1690754Species Streptomyces sp., K15 [TaxId:1931] [56604] (7 PDB entries)
    2. 1690762Species Streptomyces sp., R61 [TaxId:1931] [56605] (14 PDB entries)
      Uniprot P15555 34-378 ! Uniprot P15555
  7. 1690777D-Amino acid amidase DaaA [144038] (1 species)
  8. 1690803D-aminopeptidase, N-terminal domain [56626] (1 species)
  9. 1690806Esterase EstB [69873] (1 species)
  10. 1690812Pencillin binding protein 4 (PbpD), N-terminal domain [111287] (1 species)
  11. 1690820Penicillin binding protein 2a (PBP2A), C-terminal domain [82838] (1 species)
  12. 1690834Penicillin receptor BlaR, C-terminal domain [103375] (1 species)
    closely related to class D beta-lactamase
  13. 1690837Penicillin-binding protein 1a, transpeptidase domain [144034] (1 species)
  14. 1690841Penicillin-binding protein 1b, transpeptidase domain [144036] (1 species)
  15. 1690846Penicillin-binding protein 2, PBP2 [160970] (1 species)
  16. 1690855Penicillin-binding protein 2x (pbp-2x), transpeptidase domain [56624] (1 species)
  17. 1690875Penicillin-binding protein 5, N-terminal domain [69875] (1 species)
  18. 1690888Regulatory protein BlaR1 [111289] (1 species)
  19. 1690900automated matches [190161] (19 species)
    not a true protein
    1. 1690901Species Anthrax bacillus (Bacillus anthracis) [TaxId:1392] [196311] (1 PDB entry)
    2. 1690903Species Bacillus licheniformis [TaxId:1402] [188244] (9 PDB entries)
    3. 1690919Species Citrobacter freundii [TaxId:546] [235913] (2 PDB entries)
    4. 1690923Species Citrobacter sedlakii [TaxId:67826] [188289] (5 PDB entries)
    5. 1690944Species Enterobacter cloacae [TaxId:550] [187307] (3 PDB entries)
    6. 1690948Species Escherichia coli [TaxId:469008] [188520] (1 PDB entry)
    7. 1690950Species Escherichia coli [TaxId:562] [187306] (41 PDB entries)
    8. 1691026Species Escherichia coli [TaxId:668369] [189787] (1 PDB entry)
    9. 1691031Species Escherichia sp. [TaxId:299586] [188841] (1 PDB entry)
    10. 1691034Species Klebsiella oxytoca [TaxId:571] [188743] (1 PDB entry)
    11. 1691036Species Klebsiella pneumoniae [TaxId:573] [188184] (3 PDB entries)
    12. 1691044Species Morganella morganii [TaxId:582] [226088] (1 PDB entry)
    13. 1691047Species Oceanobacillus iheyensis [TaxId:182710] [189232] (1 PDB entry)
    14. 1691049Species Pneumococcus (Streptococcus pneumoniae) [TaxId:1313] [188417] (3 PDB entries)
    15. 1691055Species Pseudomonas aeruginosa [TaxId:287] [225853] (1 PDB entry)
    16. 1691059Species Serratia fonticola [TaxId:47917] [195324] (3 PDB entries)
    17. 1691064Species Staphylococcus aureus [TaxId:1280] [189852] (8 PDB entries)
    18. 1691081Species Staphylococcus aureus [TaxId:158878] [256157] (3 PDB entries)
    19. 1691087Species Streptomyces sp. [TaxId:31952] [186885] (1 PDB entry)

More info for Family e.3.1.1: beta-Lactamase/D-ala carboxypeptidase

Timeline for Family e.3.1.1: beta-Lactamase/D-ala carboxypeptidase: