SCOP 1.71: Family d.166.1.1: ADP-ribosylating toxins

Lineage for Family d.166.1.1: ADP-ribosylating toxins

1. Root: SCOP 1.71

2. Class d: Alpha and beta proteins (a+b) [53931] (286 folds)

3. Fold d.166: ADP-ribosylation [56398] (1 superfamily)
   unusual fold

4. Superfamily d.166.1: ADP-ribosylation [56399] (5 families)

5. Family d.166.1.1: ADP-ribosylating toxins [56400] (9 proteins)

Proteins:

1. Anthrax toxin lethal factor, middle domain [69845] (1 species)
   includes an all-alpha insert subdomain

   • Species Bacillus anthracis [TaxId:1392] [69846] (7 PDB entries)

2. Cholera toxin [56410] (1 species)

   • Species Vibrio cholerae [TaxId:666] [56411] (6 PDB entries)

3. Diphtheria toxin, N-terminal domain [56404] (1 species)

   • Species Corynebacterium diphtheriae [TaxId:1717] [56405] (7 PDB entries)

4. Enzymatic component (Ia) of iota-toxin [82812] (1 species)
   mammalian-targeted relative of VIP2; C-terminal domain is catalytic, N-terminal domain interacts with Ib (binding component)

   • Species Clostridium perfringens [TaxId:1502] [82813] (2 PDB entries)

5. Exoenzyme c3 [56414] (3 species)

   1. Species Clostridium botulinum [56415] (4 PDB entries)

   2. Species Clostridium botulinum C bacteriophage [TaxId:12336] [118161] (2 PDB entries)

   3. Species Staphylococcus aureus [TaxId:1280] [103338] (2 PDB entries)

6. Exotoxin A, C-terminal domain [56406] (1 species)

   • Species Pseudomonas aeruginosa [TaxId:287] [56407] (4 PDB entries)

7. Heat-labile toxin, A-chain [56401] (2 species)

   1. Species Escherichia coli, type IB [TaxId:562] [56402] (9 PDB entries)

   2. Species Escherichia coli, type IIB [TaxId:562] [56403] (1 PDB entry)

8. Pertussis toxin, S1 subunit [56408] (1 species)

   • Species Bordetella pertussis [TaxId:520] [56409] (3 PDB entries)

9. Vegetative insecticidal protein 2 (VIP2) [56412] (1 species)
   duplication: consists of two domains of this fold, the second of which is catalytic

   • Species Bacillus cereus [TaxId:1396] [56413] (2 PDB entries)

More info for Family d.166.1.1: ADP-ribosylating toxins

Timeline for Family d.166.1.1: ADP-ribosylating toxins:

• Family d.166.1.1: ADP-ribosylating toxins first appeared (with stable ids) in SCOP 1.55
  
• Family d.166.1.1: ADP-ribosylating toxins appears in SCOP 1.69
  
• Family d.166.1.1: ADP-ribosylating toxins appears in SCOP 1.73
  
• Family d.166.1.1: ADP-ribosylating toxins appears in the current release, SCOPe 2.08