Lineage for Protein: Lactate dehydrogenase

  1. Root: SCOP 1.67
  2. 405194Class d: Alpha and beta proteins (a+b) [53931] (260 folds)
  3. 420654Fold d.162: LDH C-terminal domain-like [56326] (1 superfamily)
    unusual fold, defines family
  4. 420655Superfamily d.162.1: LDH C-terminal domain-like [56327] (2 families) (S)
  5. 420656Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain [56328] (4 proteins)
    N-terminal domain is NAD-binding module (alpha/beta Rossmann-fold domain)
  6. 420663Protein Lactate dehydrogenase [56339] (13 species)

Species:

  1. 420664Bacillus stearothermophilus [TaxId:1422] [56344] (3 PDB entries)
    1. Domain for 1ldb:
    2. Domains for 1ldn:
      1. 420665Domain d1ldna2: 1ldn A:163-330 [42133]
        Other proteins in same PDB: d1ldna1, d1ldnb1, d1ldnc1, d1ldnd1, d1ldne1, d1ldnf1, d1ldng1, d1ldnh1
      2. 420666Domain d1ldnb2: 1ldn B:163-330 [42134]
        Other proteins in same PDB: d1ldna1, d1ldnb1, d1ldnc1, d1ldnd1, d1ldne1, d1ldnf1, d1ldng1, d1ldnh1
      3. 420667Domain d1ldnc2: 1ldn C:163-330 [42135]
        Other proteins in same PDB: d1ldna1, d1ldnb1, d1ldnc1, d1ldnd1, d1ldne1, d1ldnf1, d1ldng1, d1ldnh1
      4. 420668Domain d1ldnd2: 1ldn D:163-330 [42136]
        Other proteins in same PDB: d1ldna1, d1ldnb1, d1ldnc1, d1ldnd1, d1ldne1, d1ldnf1, d1ldng1, d1ldnh1
      5. 420669Domain d1ldne2: 1ldn E:163-330 [42137]
        Other proteins in same PDB: d1ldna1, d1ldnb1, d1ldnc1, d1ldnd1, d1ldne1, d1ldnf1, d1ldng1, d1ldnh1
      6. 420670Domain d1ldnf2: 1ldn F:163-330 [42138]
        Other proteins in same PDB: d1ldna1, d1ldnb1, d1ldnc1, d1ldnd1, d1ldne1, d1ldnf1, d1ldng1, d1ldnh1
      7. 420671Domain d1ldng2: 1ldn G:163-330 [42139]
        Other proteins in same PDB: d1ldna1, d1ldnb1, d1ldnc1, d1ldnd1, d1ldne1, d1ldnf1, d1ldng1, d1ldnh1
      8. 420672Domain d1ldnh2: 1ldn H:163-330 [42140]
        Other proteins in same PDB: d1ldna1, d1ldnb1, d1ldnc1, d1ldnd1, d1ldne1, d1ldnf1, d1ldng1, d1ldnh1
        complexed with fbp, nad, oxm
    3. Domain for 2ldb:
  2. 420675Bifidobacterium longum, strain am101-2 [TaxId:216816] [56346] (2 PDB entries)
    1. Domains for 1lld:
      1. 420676Domain d1llda2: 1lld A:150-319 [42144]
        Other proteins in same PDB: d1llda1, d1lldb1
      2. 420677Domain d1lldb2: 1lld B:150-319 [42145]
        Other proteins in same PDB: d1llda1, d1lldb1
        complexed with nad; mutant
    2. Domains for 1lth:
      1. 420678Domain d1lthr2: 1lth R:150-319 [42146]
        Other proteins in same PDB: d1lthr1, d1ltht1
      2. 420679Domain d1ltht2: 1lth T:150-319 [42147]
        Other proteins in same PDB: d1lthr1, d1ltht1
        complexed with fbp, nad, oxm; mutant
  3. 420680Dogfish (Squalus acanthias) [TaxId:7797] [56342] (3 PDB entries)
    1. Domain for 1ldm:
    2. Domain for 6ldh:
    3. Domain for 8ldh:
  4. 420684Human (Homo sapiens), heart isoform (H chain) [TaxId:9606] [64444] (2 PDB entries)
    1. Domains for 1i0z:
      1. 420685Domain d1i0za2: 1i0z A:161-332 [61496]
        Other proteins in same PDB: d1i0za1, d1i0zb1
      2. 420686Domain d1i0zb2: 1i0z B:161-332 [61498]
        Other proteins in same PDB: d1i0za1, d1i0zb1
        complexed with nai, oxm
    2. Domains for 1t2f:
      1. 420687Domain d1t2fa2: 1t2f A:161-332 [99089]
        Other proteins in same PDB: d1t2fa1, d1t2fb1, d1t2fc1, d1t2fd1
      2. 420688Domain d1t2fb2: 1t2f B:161-332 [99091]
        Other proteins in same PDB: d1t2fa1, d1t2fb1, d1t2fc1, d1t2fd1
      3. 420689Domain d1t2fc2: 1t2f C:161-332 [99093]
        Other proteins in same PDB: d1t2fa1, d1t2fb1, d1t2fc1, d1t2fd1
      4. 420690Domain d1t2fd2: 1t2f D:161-332 [99095]
        Other proteins in same PDB: d1t2fa1, d1t2fb1, d1t2fc1, d1t2fd1
        complexed with nad, oxq; mutant
  5. 420691Human (Homo sapiens), muscle isoform (M chain) [TaxId:9606] [64445] (1 PDB entry)
  6. 420700Lactobacillus casei [TaxId:1582] [56345] (1 PDB entry)
  7. 420702Lactobacillus pentosus [TaxId:1589] [69843] (1 PDB entry)
  8. 420707Malaria parasite (Plasmodium falciparum) [TaxId:5833] [56343] (9 PDB entries)
    1. Domain for 1ceq:
    2. Domain for 1cet:
    3. Domain for 1ldg:
    4. Domain for 1t24:
    5. Domain for 1t25:
    6. Domain for 1t26:
    7. Domain for 1t2c:
    8. Domain for 1t2d:
    9. Domain for 1t2e:
  9. 420717Mouse (Mus musculus) [TaxId:10090] [56341] (1 PDB entry)
  10. 420719Pig (Sus scrofa) [TaxId:9823] [56340] (3 PDB entries)
    1. Domain for 5ldh:
    2. Domains for 9ldb:
      1. 420722Domain d9ldba2: 9ldb A:163-331 [42123]
        Other proteins in same PDB: d9ldba1, d9ldbb1
      2. 420723Domain d9ldbb2: 9ldb B:163-331 [42124]
        Other proteins in same PDB: d9ldba1, d9ldbb1
        complexed with nad, oxm, so4
    3. Domains for 9ldt:
      1. 420720Domain d9ldta2: 9ldt A:163-331 [42121]
        Other proteins in same PDB: d9ldta1, d9ldtb1
      2. 420721Domain d9ldtb2: 9ldt B:163-331 [42122]
        Other proteins in same PDB: d9ldta1, d9ldtb1
        complexed with nad, oxm, so4
  11. 420725Plasmodium berghei [103325] (1 PDB entry)
  12. 420728Thermotoga maritima [TaxId:243274] [56347] (1 PDB entry)
  13. 420730Toxoplasma gondii [TaxId:5811] [103326] (4 PDB entries)
    1. Domain for 1pze:
    2. Domains for 1pzf:
      1. 420740Domain d1pzfa2: 1pzf A:164-334 [95418]
        Other proteins in same PDB: d1pzfa1, d1pzfb1, d1pzfc1, d1pzfd1
      2. 420741Domain d1pzfb2: 1pzf B:164-334 [95420]
        Other proteins in same PDB: d1pzfa1, d1pzfb1, d1pzfc1, d1pzfd1
      3. 420742Domain d1pzfc2: 1pzf C:164-332 [95422]
        Other proteins in same PDB: d1pzfa1, d1pzfb1, d1pzfc1, d1pzfd1
      4. 420743Domain d1pzfd2: 1pzf D:164-332 [95424]
        Other proteins in same PDB: d1pzfa1, d1pzfb1, d1pzfc1, d1pzfd1
        complexed with a3d, oxl
    3. Domains for 1pzg:
      1. 420732Domain d1pzga2: 1pzg A:164-334 [95426]
        Other proteins in same PDB: d1pzga1, d1pzgb1, d1pzgc1, d1pzgd1
      2. 420733Domain d1pzgb2: 1pzg B:164-334 [95428]
        Other proteins in same PDB: d1pzga1, d1pzgb1, d1pzgc1, d1pzgd1
      3. 420734Domain d1pzgc2: 1pzg C:164-332 [95430]
        Other proteins in same PDB: d1pzga1, d1pzgb1, d1pzgc1, d1pzgd1
      4. 420735Domain d1pzgd2: 1pzg D:164-332 [95432]
        Other proteins in same PDB: d1pzga1, d1pzgb1, d1pzgc1, d1pzgd1
        complexed with a3d, so4
    4. Domains for 1pzh:
      1. 420736Domain d1pzha2: 1pzh A:164-335 [95434]
        Other proteins in same PDB: d1pzha1, d1pzhb1, d1pzhc1, d1pzhd1
      2. 420737Domain d1pzhb2: 1pzh B:164-335 [95436]
        Other proteins in same PDB: d1pzha1, d1pzhb1, d1pzhc1, d1pzhd1
      3. 420738Domain d1pzhc2: 1pzh C:164-332 [95438]
        Other proteins in same PDB: d1pzha1, d1pzhb1, d1pzhc1, d1pzhd1
      4. 420739Domain d1pzhd2: 1pzh D:164-332 [95440]
        Other proteins in same PDB: d1pzha1, d1pzhb1, d1pzhc1, d1pzhd1
        complexed with nad, oxl

More info for Protein Lactate dehydrogenase from d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain

Timeline for Protein Lactate dehydrogenase from d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain: