Lineage for Protein: S-adenosylmethionine synthetase

  1. Root: SCOPe 2.06
  2. 2170735Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2215558Fold d.130: S-adenosylmethionine synthetase [55972] (1 superfamily)
    duplication: consists of 3 similar intertwined domains
    structural repeat: beta-alpha-beta(2)-alpha-beta; two layers, alpha/beta
  4. 2215559Superfamily d.130.1: S-adenosylmethionine synthetase [55973] (2 families) (S)
  5. 2215560Family d.130.1.1: S-adenosylmethionine synthetase [55974] (1 protein)
  6. 2215561Protein S-adenosylmethionine synthetase [55975] (3 species)
    synonym: methionine adenosyltransferase, MAT

Species:

  1. 2215562Escherichia coli [TaxId:562] [55976] (9 PDB entries)
    1. Domains for 1fug:
      1. 2215605Domain d1fuga1: 1fug A:1-102 [41344]
      2. 2215606Domain d1fuga2: 1fug A:103-231 [41345]
      3. 2215607Domain d1fuga3: 1fug A:232-383 [41346]
      4. 2215608Domain d1fugb1: 1fug B:1-102 [41347]
      5. 2215609Domain d1fugb2: 1fug B:103-231 [41348]
      6. 2215610Domain d1fugb3: 1fug B:232-383 [41349]
    2. Domains for 1mxa:
      1. 2215563Domain d1mxaa1: 1mxa A:1-102 [41326]
        complexed with k, mg, po4, pop
      2. 2215564Domain d1mxaa2: 1mxa A:108-231 [41327]
        complexed with k, mg, po4, pop
      3. 2215565Domain d1mxaa3: 1mxa A:232-383 [41328]
        complexed with k, mg, po4, pop
    3. Domains for 1mxb:
      1. 2215566Domain d1mxba1: 1mxb A:1-102 [41329]
        complexed with adp, k, mg, po4
      2. 2215567Domain d1mxba2: 1mxb A:108-231 [41330]
        complexed with adp, k, mg, po4
      3. 2215568Domain d1mxba3: 1mxb A:232-383 [41331]
        complexed with adp, k, mg, po4
    4. Domains for 1mxc:
      1. 2215569Domain d1mxca1: 1mxc A:1-102 [41332]
        complexed with abp, k, mg, po4
      2. 2215570Domain d1mxca2: 1mxc A:108-231 [41333]
        complexed with abp, k, mg, po4
      3. 2215571Domain d1mxca3: 1mxc A:232-383 [41334]
        complexed with abp, k, mg, po4
    5. Domains for 1p7l:
      1. 2215590Domain d1p7la1: 1p7l A:1-102 [94295]
        complexed with anp, k, met, mg, ppk, sam
      2. 2215591Domain d1p7la2: 1p7l A:103-231 [94296]
        complexed with anp, k, met, mg, ppk, sam
      3. 2215592Domain d1p7la3: 1p7l A:232-383 [94297]
        complexed with anp, k, met, mg, ppk, sam
      4. 2215593Domain d1p7lb1: 1p7l B:1-102 [94298]
        complexed with anp, k, met, mg, ppk, sam
      5. 2215594Domain d1p7lb2: 1p7l B:103-231 [94299]
        complexed with anp, k, met, mg, ppk, sam
      6. 2215595Domain d1p7lb3: 1p7l B:232-383 [94300]
        complexed with anp, k, met, mg, ppk, sam
      7. 2215596Domain d1p7lc1: 1p7l C:1-102 [94301]
        complexed with anp, k, met, mg, ppk, sam
      8. 2215597Domain d1p7lc2: 1p7l C:103-231 [94302]
        complexed with anp, k, met, mg, ppk, sam
      9. 2215598Domain d1p7lc3: 1p7l C:232-383 [94303]
        complexed with anp, k, met, mg, ppk, sam
      10. 2215599Domain d1p7ld1: 1p7l D:1-102 [94304]
        complexed with anp, k, met, mg, ppk, sam
      11. 2215600Domain d1p7ld2: 1p7l D:103-231 [94305]
        complexed with anp, k, met, mg, ppk, sam
      12. 2215601Domain d1p7ld3: 1p7l D:232-383 [94306]
        complexed with anp, k, met, mg, ppk, sam
    6. Domains for 1rg9:
      1. 2215575Domain d1rg9a1: 1rg9 A:1-102 [97427]
        complexed with k, mg, ppk, sam
      2. 2215576Domain d1rg9a2: 1rg9 A:103-231 [97428]
        complexed with k, mg, ppk, sam
      3. 2215577Domain d1rg9a3: 1rg9 A:232-383 [97429]
        complexed with k, mg, ppk, sam
      4. 2215578Domain d1rg9b1: 1rg9 B:1-102 [97430]
        complexed with k, mg, ppk, sam
      5. 2215579Domain d1rg9b2: 1rg9 B:103-231 [97431]
        complexed with k, mg, ppk, sam
      6. 2215580Domain d1rg9b3: 1rg9 B:232-383 [97432]
        complexed with k, mg, ppk, sam
      7. 2215581Domain d1rg9c1: 1rg9 C:1-102 [97433]
        complexed with k, mg, ppk, sam
      8. 2215582Domain d1rg9c2: 1rg9 C:103-231 [97434]
        complexed with k, mg, ppk, sam
      9. 2215583Domain d1rg9c3: 1rg9 C:232-383 [97435]
        complexed with k, mg, ppk, sam
      10. 2215584Domain d1rg9d1: 1rg9 D:1-102 [97436]
        complexed with k, mg, ppk, sam
      11. 2215585Domain d1rg9d2: 1rg9 D:103-231 [97437]
        complexed with k, mg, ppk, sam
      12. 2215586Domain d1rg9d3: 1rg9 D:232-383 [97438]
        complexed with k, mg, ppk, sam
    7. Domains for 1xra:
      1. 2215602Domain d1xraa1: 1xra A:1-101 [41341]
        complexed with k, mg, po4
      2. 2215603Domain d1xraa2: 1xra A:108-231 [41342]
        complexed with k, mg, po4
      3. 2215604Domain d1xraa3: 1xra A:232-383 [41343]
        complexed with k, mg, po4
    8. Domains for 1xrb:
      1. 2215572Domain d1xrba1: 1xrb A:1-101 [41335]
        complexed with k, mg, po4
      2. 2215573Domain d1xrba2: 1xrb A:108-231 [41336]
        complexed with k, mg, po4
      3. 2215574Domain d1xrba3: 1xrb A:232-383 [41337]
        complexed with k, mg, po4
    9. Domains for 1xrc:
      1. 2215587Domain d1xrca1: 1xrc A:1-101 [41338]
        complexed with co, k, po4
      2. 2215588Domain d1xrca2: 1xrc A:108-231 [41339]
        complexed with co, k, po4
      3. 2215589Domain d1xrca3: 1xrc A:232-383 [41340]
        complexed with co, k, po4
  2. 2215611Human (Homo sapiens), isoform type-2 [TaxId:9606] [160759] (3 PDB entries)
    Uniprot P31153 126-251! Uniprot P31153 16-125! Uniprot P31153 252-395
    MAT2A
    1. Domains for 2hj2:
      1. 2215612Domain d2hj2a1: 2hj2 A:16-125 [304011]
        automated match to d2p02a1
        complexed with cl, sam
      2. 2215613Domain d2hj2a2: 2hj2 A:126-251 [304012]
        automated match to d2p02a2
        complexed with cl, sam
      3. 2215614Domain d2hj2a3: 2hj2 A:252-395 [304013]
        automated match to d2p02a3
        complexed with cl, sam
      4. 2215615Domain d2hj2b1: 2hj2 B:16-125 [304014]
        automated match to d2p02a1
        complexed with cl, sam
      5. 2215616Domain d2hj2b2: 2hj2 B:126-251 [304015]
        automated match to d2p02a2
        complexed with cl, sam
      6. 2215617Domain d2hj2b3: 2hj2 B:252-395 [304016]
        automated match to d2p02a3
        complexed with cl, sam
    2. Domains for 2p02:
      1. 2215618Domain d2p02a1: 2p02 A:38-147 [149132]
        complexed with cl, sam
      2. 2215619Domain d2p02a2: 2p02 A:148-273 [149133]
        complexed with cl, sam
      3. 2215620Domain d2p02a3: 2p02 A:274-417 [149134]
        complexed with cl, sam
    3. Domains for 4ktt:
      1. 2215621Domain d4ktta1: 4ktt A:15-115 [257811]
        Other proteins in same PDB: d4ktte_, d4kttf_
        automated match to d2p02a1
        complexed with edo, mg, po4, sam
      2. 2215622Domain d4ktta2: 4ktt A:135-251 [257812]
        Other proteins in same PDB: d4ktte_, d4kttf_
        automated match to d2p02a2
        complexed with edo, mg, po4, sam
      3. 2215623Domain d4ktta3: 4ktt A:252-395 [257813]
        Other proteins in same PDB: d4ktte_, d4kttf_
        automated match to d2p02a3
        complexed with edo, mg, po4, sam
      4. 2215624Domain d4kttb1: 4ktt B:14-125 [257808]
        Other proteins in same PDB: d4ktte_, d4kttf_
        automated match to d2p02a1
        complexed with edo, mg, po4, sam
      5. 2215625Domain d4kttb2: 4ktt B:126-251 [257809]
        Other proteins in same PDB: d4ktte_, d4kttf_
        automated match to d2p02a2
        complexed with edo, mg, po4, sam
      6. 2215626Domain d4kttb3: 4ktt B:252-395 [257810]
        Other proteins in same PDB: d4ktte_, d4kttf_
        automated match to d2p02a3
        complexed with edo, mg, po4, sam
      7. 2215627Domain d4kttc1: 4ktt C:15-115 [257805]
        Other proteins in same PDB: d4ktte_, d4kttf_
        automated match to d2p02a1
        complexed with edo, mg, po4, sam
      8. 2215628Domain d4kttc2: 4ktt C:134-251 [257806]
        Other proteins in same PDB: d4ktte_, d4kttf_
        automated match to d2p02a2
        complexed with edo, mg, po4, sam
      9. 2215629Domain d4kttc3: 4ktt C:252-395 [257807]
        Other proteins in same PDB: d4ktte_, d4kttf_
        automated match to d2p02a3
        complexed with edo, mg, po4, sam
      10. 2215630Domain d4kttd1: 4ktt D:16-125 [257814]
        Other proteins in same PDB: d4ktte_, d4kttf_
        automated match to d2p02a1
        complexed with edo, mg, po4, sam
      11. 2215631Domain d4kttd2: 4ktt D:126-251 [257815]
        Other proteins in same PDB: d4ktte_, d4kttf_
        automated match to d2p02a2
        complexed with edo, mg, po4, sam
      12. 2215632Domain d4kttd3: 4ktt D:252-395 [257816]
        Other proteins in same PDB: d4ktte_, d4kttf_
        automated match to d2p02a3
        complexed with edo, mg, po4, sam
  3. 2215633Norway rat (Rattus norvegicus) [TaxId:10116] [55977] (5 PDB entries)
    1. Domains for 1o90:
      1. 2215646Domain d1o90a1: 1o90 A:17-116 [92650]
        complexed with k, lis, mg, po4
      2. 2215647Domain d1o90a2: 1o90 A:129-252 [92651]
        complexed with k, lis, mg, po4
      3. 2215648Domain d1o90a3: 1o90 A:253-396 [92652]
        complexed with k, lis, mg, po4
      4. 2215649Domain d1o90b1: 1o90 B:17-116 [92653]
        complexed with k, lis, mg, po4
      5. 2215650Domain d1o90b2: 1o90 B:129-252 [92654]
        complexed with k, lis, mg, po4
      6. 2215651Domain d1o90b3: 1o90 B:253-396 [92655]
        complexed with k, lis, mg, po4
    2. Domains for 1o92:
      1. 2215652Domain d1o92a1: 1o92 A:17-116 [92659]
        complexed with adp, amb, k, mg, po4
      2. 2215653Domain d1o92a2: 1o92 A:129-252 [92660]
        complexed with adp, amb, k, mg, po4
      3. 2215654Domain d1o92a3: 1o92 A:253-396 [92661]
        complexed with adp, amb, k, mg, po4
      4. 2215655Domain d1o92b1: 1o92 B:17-116 [92662]
        complexed with adp, amb, k, mg, po4
      5. 2215656Domain d1o92b2: 1o92 B:129-252 [92663]
        complexed with adp, amb, k, mg, po4
      6. 2215657Domain d1o92b3: 1o92 B:253-396 [92664]
        complexed with adp, amb, k, mg, po4
    3. Domains for 1o93:
      1. 2215658Domain d1o93a1: 1o93 A:17-116 [92665]
        complexed with atp, k, lis, mg, po4
      2. 2215659Domain d1o93a2: 1o93 A:129-252 [92666]
        complexed with atp, k, lis, mg, po4
      3. 2215660Domain d1o93a3: 1o93 A:253-396 [92667]
        complexed with atp, k, lis, mg, po4
      4. 2215661Domain d1o93b1: 1o93 B:17-116 [92668]
        complexed with atp, k, lis, mg, po4
      5. 2215662Domain d1o93b2: 1o93 B:129-252 [92669]
        complexed with atp, k, lis, mg, po4
      6. 2215663Domain d1o93b3: 1o93 B:253-396 [92670]
        complexed with atp, k, lis, mg, po4
    4. Domains for 1o9t:
      1. 2215640Domain d1o9ta1: 1o9t A:17-116 [92685]
        complexed with both substrates ATP and methionine
        complexed with atp, k, met, mg, po4
      2. 2215641Domain d1o9ta2: 1o9t A:129-252 [92686]
        complexed with both substrates ATP and methionine
        complexed with atp, k, met, mg, po4
      3. 2215642Domain d1o9ta3: 1o9t A:253-396 [92687]
        complexed with both substrates ATP and methionine
        complexed with atp, k, met, mg, po4
      4. 2215643Domain d1o9tb1: 1o9t B:17-116 [92688]
        complexed with both substrates ATP and methionine
        complexed with atp, k, met, mg, po4
      5. 2215644Domain d1o9tb2: 1o9t B:129-252 [92689]
        complexed with both substrates ATP and methionine
        complexed with atp, k, met, mg, po4
      6. 2215645Domain d1o9tb3: 1o9t B:253-396 [92690]
        complexed with both substrates ATP and methionine
        complexed with atp, k, met, mg, po4
    5. Domains for 1qm4:
      1. 2215634Domain d1qm4a1: 1qm4 A:17-116 [41350]
        complexed with amb, k, mg, so4
      2. 2215635Domain d1qm4a2: 1qm4 A:129-252 [41351]
        complexed with amb, k, mg, so4
      3. 2215636Domain d1qm4a3: 1qm4 A:253-396 [41352]
        complexed with amb, k, mg, so4
      4. 2215637Domain d1qm4b1: 1qm4 B:17-116 [41353]
        complexed with amb, k, mg, so4
      5. 2215638Domain d1qm4b2: 1qm4 B:129-252 [41354]
        complexed with amb, k, mg, so4
      6. 2215639Domain d1qm4b3: 1qm4 B:253-396 [41355]
        complexed with amb, k, mg, so4

More info for Protein S-adenosylmethionine synthetase from d.130.1.1: S-adenosylmethionine synthetase

Timeline for Protein S-adenosylmethionine synthetase from d.130.1.1: S-adenosylmethionine synthetase: