Lineage for Protein: S-adenosylmethionine synthetase

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2539659Fold d.130: S-adenosylmethionine synthetase [55972] (1 superfamily)
    duplication: consists of 3 similar intertwined domains
    structural repeat: beta-alpha-beta(2)-alpha-beta; two layers, alpha/beta
  4. 2539660Superfamily d.130.1: S-adenosylmethionine synthetase [55973] (2 families) (S)
  5. 2539661Family d.130.1.1: S-adenosylmethionine synthetase [55974] (2 proteins)
  6. 2539662Protein S-adenosylmethionine synthetase [55975] (3 species)
    synonym: methionine adenosyltransferase, MAT

Species:

  1. 2539663Escherichia coli [TaxId:562] [55976] (9 PDB entries)
    1. Domains for 1fug:
      1. 2539706Domain d1fuga1: 1fug A:1-102 [41344]
      2. 2539707Domain d1fuga2: 1fug A:103-231 [41345]
      3. 2539708Domain d1fuga3: 1fug A:232-383 [41346]
      4. 2539709Domain d1fugb1: 1fug B:1-102 [41347]
      5. 2539710Domain d1fugb2: 1fug B:103-231 [41348]
      6. 2539711Domain d1fugb3: 1fug B:232-383 [41349]
    2. Domains for 1mxa:
      1. 2539664Domain d1mxaa1: 1mxa A:1-102 [41326]
        complexed with k, mg, po4, pop
      2. 2539665Domain d1mxaa2: 1mxa A:108-231 [41327]
        complexed with k, mg, po4, pop
      3. 2539666Domain d1mxaa3: 1mxa A:232-383 [41328]
        complexed with k, mg, po4, pop
    3. Domains for 1mxb:
      1. 2539667Domain d1mxba1: 1mxb A:1-102 [41329]
        complexed with adp, k, mg, po4
      2. 2539668Domain d1mxba2: 1mxb A:108-231 [41330]
        complexed with adp, k, mg, po4
      3. 2539669Domain d1mxba3: 1mxb A:232-383 [41331]
        complexed with adp, k, mg, po4
    4. Domains for 1mxc:
      1. 2539670Domain d1mxca1: 1mxc A:1-102 [41332]
        complexed with abp, k, mg, po4
      2. 2539671Domain d1mxca2: 1mxc A:108-231 [41333]
        complexed with abp, k, mg, po4
      3. 2539672Domain d1mxca3: 1mxc A:232-383 [41334]
        complexed with abp, k, mg, po4
    5. Domains for 1p7l:
      1. 2539694Domain d1p7la1: 1p7l A:1-102 [94295]
        complexed with anp, k, met, mg, ppk, sam
      2. 2539695Domain d1p7la2: 1p7l A:103-231 [94296]
        complexed with anp, k, met, mg, ppk, sam
      3. 2539696Domain d1p7la3: 1p7l A:232-383 [94297]
        complexed with anp, k, met, mg, ppk, sam
      4. 2539697Domain d1p7lb1: 1p7l B:1-102 [94298]
        complexed with anp, k, met, mg, ppk, sam
      5. 2539698Domain d1p7lb2: 1p7l B:103-231 [94299]
        complexed with anp, k, met, mg, ppk, sam
      6. 2539699Domain d1p7lb3: 1p7l B:232-383 [94300]
        complexed with anp, k, met, mg, ppk, sam
      7. 2539700Domain d1p7lc1: 1p7l C:1-102 [94301]
        complexed with anp, k, met, mg, ppk, sam
      8. 2539701Domain d1p7lc2: 1p7l C:103-231 [94302]
        complexed with anp, k, met, mg, ppk, sam
      9. 2539702Domain d1p7lc3: 1p7l C:232-383 [94303]
        complexed with anp, k, met, mg, ppk, sam
      10. 2539703Domain d1p7ld1: 1p7l D:1-102 [94304]
        complexed with anp, k, met, mg, ppk, sam
      11. 2539704Domain d1p7ld2: 1p7l D:103-231 [94305]
        complexed with anp, k, met, mg, ppk, sam
      12. 2539705Domain d1p7ld3: 1p7l D:232-383 [94306]
        complexed with anp, k, met, mg, ppk, sam
    6. Domains for 1rg9:
      1. 2539682Domain d1rg9a1: 1rg9 A:1-102 [97427]
        complexed with k, mg, ppk, sam
      2. 2539683Domain d1rg9a2: 1rg9 A:103-231 [97428]
        complexed with k, mg, ppk, sam
      3. 2539684Domain d1rg9a3: 1rg9 A:232-383 [97429]
        complexed with k, mg, ppk, sam
      4. 2539685Domain d1rg9b1: 1rg9 B:1-102 [97430]
        complexed with k, mg, ppk, sam
      5. 2539686Domain d1rg9b2: 1rg9 B:103-231 [97431]
        complexed with k, mg, ppk, sam
      6. 2539687Domain d1rg9b3: 1rg9 B:232-383 [97432]
        complexed with k, mg, ppk, sam
      7. 2539688Domain d1rg9c1: 1rg9 C:1-102 [97433]
        complexed with k, mg, ppk, sam
      8. 2539689Domain d1rg9c2: 1rg9 C:103-231 [97434]
        complexed with k, mg, ppk, sam
      9. 2539690Domain d1rg9c3: 1rg9 C:232-383 [97435]
        complexed with k, mg, ppk, sam
      10. 2539691Domain d1rg9d1: 1rg9 D:1-102 [97436]
        complexed with k, mg, ppk, sam
      11. 2539692Domain d1rg9d2: 1rg9 D:103-231 [97437]
        complexed with k, mg, ppk, sam
      12. 2539693Domain d1rg9d3: 1rg9 D:232-383 [97438]
        complexed with k, mg, ppk, sam
    7. Domains for 1xra:
      1. 2539679Domain d1xraa1: 1xra A:1-101 [41341]
        complexed with k, mg, po4
      2. 2539680Domain d1xraa2: 1xra A:108-231 [41342]
        complexed with k, mg, po4
      3. 2539681Domain d1xraa3: 1xra A:232-383 [41343]
        complexed with k, mg, po4
    8. Domains for 1xrb:
      1. 2539673Domain d1xrba1: 1xrb A:1-101 [41335]
        complexed with k, mg, po4
      2. 2539674Domain d1xrba2: 1xrb A:108-231 [41336]
        complexed with k, mg, po4
      3. 2539675Domain d1xrba3: 1xrb A:232-383 [41337]
        complexed with k, mg, po4
    9. Domains for 1xrc:
      1. 2539676Domain d1xrca1: 1xrc A:1-101 [41338]
        complexed with co, k, po4
      2. 2539677Domain d1xrca2: 1xrc A:108-231 [41339]
        complexed with co, k, po4
      3. 2539678Domain d1xrca3: 1xrc A:232-383 [41340]
        complexed with co, k, po4
  2. 2539712Human (Homo sapiens), isoform type-2 [TaxId:9606] [160759] (3 PDB entries)
    Uniprot P31153 126-251! Uniprot P31153 16-125! Uniprot P31153 252-395
    MAT2A
    1. Domains for 2hj2:
      1. 2539713Domain d2hj2a1: 2hj2 A:16-125 [304011]
        automated match to d2p02a1
        complexed with cl, sam
      2. 2539714Domain d2hj2a2: 2hj2 A:126-251 [304012]
        automated match to d2p02a2
        complexed with cl, sam
      3. 2539715Domain d2hj2a3: 2hj2 A:252-395 [304013]
        automated match to d2p02a3
        complexed with cl, sam
      4. 2539716Domain d2hj2b1: 2hj2 B:16-125 [304014]
        automated match to d2p02a1
        complexed with cl, sam
      5. 2539717Domain d2hj2b2: 2hj2 B:126-251 [304015]
        automated match to d2p02a2
        complexed with cl, sam
      6. 2539718Domain d2hj2b3: 2hj2 B:252-395 [304016]
        automated match to d2p02a3
        complexed with cl, sam
    2. Domains for 2p02:
      1. 2539719Domain d2p02a1: 2p02 A:38-147 [149132]
        complexed with cl, sam
      2. 2539720Domain d2p02a2: 2p02 A:148-273 [149133]
        complexed with cl, sam
      3. 2539721Domain d2p02a3: 2p02 A:274-417 [149134]
        complexed with cl, sam
    3. Domains for 4ktt:
      1. 2539722Domain d4ktta1: 4ktt A:15-115 [257811]
        Other proteins in same PDB: d4ktte_, d4kttf_
        automated match to d2p02a1
        complexed with edo, mg, po4, sam
      2. 2539723Domain d4ktta2: 4ktt A:135-251 [257812]
        Other proteins in same PDB: d4ktte_, d4kttf_
        automated match to d2p02a2
        complexed with edo, mg, po4, sam
      3. 2539724Domain d4ktta3: 4ktt A:252-395 [257813]
        Other proteins in same PDB: d4ktte_, d4kttf_
        automated match to d2p02a3
        complexed with edo, mg, po4, sam
      4. 2539725Domain d4kttb1: 4ktt B:14-125 [257808]
        Other proteins in same PDB: d4ktte_, d4kttf_
        automated match to d2p02a1
        complexed with edo, mg, po4, sam
      5. 2539726Domain d4kttb2: 4ktt B:126-251 [257809]
        Other proteins in same PDB: d4ktte_, d4kttf_
        automated match to d2p02a2
        complexed with edo, mg, po4, sam
      6. 2539727Domain d4kttb3: 4ktt B:252-395 [257810]
        Other proteins in same PDB: d4ktte_, d4kttf_
        automated match to d2p02a3
        complexed with edo, mg, po4, sam
      7. 2539728Domain d4kttc1: 4ktt C:15-115 [257805]
        Other proteins in same PDB: d4ktte_, d4kttf_
        automated match to d2p02a1
        complexed with edo, mg, po4, sam
      8. 2539729Domain d4kttc2: 4ktt C:134-251 [257806]
        Other proteins in same PDB: d4ktte_, d4kttf_
        automated match to d2p02a2
        complexed with edo, mg, po4, sam
      9. 2539730Domain d4kttc3: 4ktt C:252-395 [257807]
        Other proteins in same PDB: d4ktte_, d4kttf_
        automated match to d2p02a3
        complexed with edo, mg, po4, sam
      10. 2539731Domain d4kttd1: 4ktt D:16-125 [257814]
        Other proteins in same PDB: d4ktte_, d4kttf_
        automated match to d2p02a1
        complexed with edo, mg, po4, sam
      11. 2539732Domain d4kttd2: 4ktt D:126-251 [257815]
        Other proteins in same PDB: d4ktte_, d4kttf_
        automated match to d2p02a2
        complexed with edo, mg, po4, sam
      12. 2539733Domain d4kttd3: 4ktt D:252-395 [257816]
        Other proteins in same PDB: d4ktte_, d4kttf_
        automated match to d2p02a3
        complexed with edo, mg, po4, sam
  3. 2539734Norway rat (Rattus norvegicus) [TaxId:10116] [55977] (5 PDB entries)
    1. Domains for 1o90:
      1. 2539741Domain d1o90a1: 1o90 A:17-116 [92650]
        complexed with k, lis, mg, po4
      2. 2539742Domain d1o90a2: 1o90 A:129-252 [92651]
        complexed with k, lis, mg, po4
      3. 2539743Domain d1o90a3: 1o90 A:253-396 [92652]
        complexed with k, lis, mg, po4
      4. 2539744Domain d1o90b1: 1o90 B:17-116 [92653]
        complexed with k, lis, mg, po4
      5. 2539745Domain d1o90b2: 1o90 B:129-252 [92654]
        complexed with k, lis, mg, po4
      6. 2539746Domain d1o90b3: 1o90 B:253-396 [92655]
        complexed with k, lis, mg, po4
    2. Domains for 1o92:
      1. 2539747Domain d1o92a1: 1o92 A:17-116 [92659]
        complexed with adp, amb, k, mg, po4
      2. 2539748Domain d1o92a2: 1o92 A:129-252 [92660]
        complexed with adp, amb, k, mg, po4
      3. 2539749Domain d1o92a3: 1o92 A:253-396 [92661]
        complexed with adp, amb, k, mg, po4
      4. 2539750Domain d1o92b1: 1o92 B:17-116 [92662]
        complexed with adp, amb, k, mg, po4
      5. 2539751Domain d1o92b2: 1o92 B:129-252 [92663]
        complexed with adp, amb, k, mg, po4
      6. 2539752Domain d1o92b3: 1o92 B:253-396 [92664]
        complexed with adp, amb, k, mg, po4
    3. Domains for 1o93:
      1. 2539753Domain d1o93a1: 1o93 A:17-116 [92665]
        complexed with atp, k, lis, mg, po4
      2. 2539754Domain d1o93a2: 1o93 A:129-252 [92666]
        complexed with atp, k, lis, mg, po4
      3. 2539755Domain d1o93a3: 1o93 A:253-396 [92667]
        complexed with atp, k, lis, mg, po4
      4. 2539756Domain d1o93b1: 1o93 B:17-116 [92668]
        complexed with atp, k, lis, mg, po4
      5. 2539757Domain d1o93b2: 1o93 B:129-252 [92669]
        complexed with atp, k, lis, mg, po4
      6. 2539758Domain d1o93b3: 1o93 B:253-396 [92670]
        complexed with atp, k, lis, mg, po4
    4. Domains for 1o9t:
      1. 2539735Domain d1o9ta1: 1o9t A:17-116 [92685]
        complexed with both substrates ATP and methionine
        complexed with atp, k, met, mg, po4
      2. 2539736Domain d1o9ta2: 1o9t A:129-252 [92686]
        complexed with both substrates ATP and methionine
        complexed with atp, k, met, mg, po4
      3. 2539737Domain d1o9ta3: 1o9t A:253-396 [92687]
        complexed with both substrates ATP and methionine
        complexed with atp, k, met, mg, po4
      4. 2539738Domain d1o9tb1: 1o9t B:17-116 [92688]
        complexed with both substrates ATP and methionine
        complexed with atp, k, met, mg, po4
      5. 2539739Domain d1o9tb2: 1o9t B:129-252 [92689]
        complexed with both substrates ATP and methionine
        complexed with atp, k, met, mg, po4
      6. 2539740Domain d1o9tb3: 1o9t B:253-396 [92690]
        complexed with both substrates ATP and methionine
        complexed with atp, k, met, mg, po4
    5. Domains for 1qm4:
      1. 2539759Domain d1qm4a1: 1qm4 A:17-116 [41350]
        complexed with amb, k, mg, so4
      2. 2539760Domain d1qm4a2: 1qm4 A:129-252 [41351]
        complexed with amb, k, mg, so4
      3. 2539761Domain d1qm4a3: 1qm4 A:253-396 [41352]
        complexed with amb, k, mg, so4
      4. 2539762Domain d1qm4b1: 1qm4 B:17-116 [41353]
        complexed with amb, k, mg, so4
      5. 2539763Domain d1qm4b2: 1qm4 B:129-252 [41354]
        complexed with amb, k, mg, so4
      6. 2539764Domain d1qm4b3: 1qm4 B:253-396 [41355]
        complexed with amb, k, mg, so4

More info for Protein S-adenosylmethionine synthetase from d.130.1.1: S-adenosylmethionine synthetase

Timeline for Protein S-adenosylmethionine synthetase from d.130.1.1: S-adenosylmethionine synthetase: