SCOPe 2.05: Family d.96.1.3: DHN aldolase/epimerase

Lineage for Family d.96.1.3: DHN aldolase/epimerase

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.96: T-fold [55619] (2 superfamilies)
   beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1234
   tunnel-shaped: its known members form wide oligomeric barrels different sizes

4. Superfamily d.96.1: Tetrahydrobiopterin biosynthesis enzymes-like [55620] (5 families)
   bind purine or pterin in topologically similar sites between subunits

5. Family d.96.1.3: DHN aldolase/epimerase [55628] (2 proteins)
   beta-sheets of four subunits form a barrel, closed: n=16, S=16
   automatically mapped to Pfam PF02152

Proteins:

1. 7,8-dihydroneopterin aldolase [55629] (4 species)

   1. Species Bacillus anthracis [TaxId:261594] [280019] (1 PDB entry)

   2. Species Mycobacterium tuberculosis [TaxId:1773] [103143] (2 PDB entries)
      Uniprot O06275 2-115

   3. Species Staphylococcus aureus [TaxId:1280] [55630] (12 PDB entries)
      Uniprot P56740

   4. Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [111088] (1 PDB entry)
      Uniprot Q9SF23

2. 7,8-dihydroneopterin triphosphate epimerase [55631] (1 species)

   • Species Escherichia coli [TaxId:562] [55632] (1 PDB entry)

More info for Family d.96.1.3: DHN aldolase/epimerase

Timeline for Family d.96.1.3: DHN aldolase/epimerase:

• Family d.96.1.3: DHN aldolase/epimerase first appeared (with stable ids) in SCOP 1.55
  
• Family d.96.1.3: DHN aldolase/epimerase appears in SCOPe 2.04
  
• Family d.96.1.3: DHN aldolase/epimerase appears in SCOPe 2.06
  
• Family d.96.1.3: DHN aldolase/epimerase appears in the current release, SCOPe 2.08