SCOPe 2.07: Protein: Phosphatidylinositol 3-kinase, p85-alpha subunit

Root: SCOPe 2.07
Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
Fold d.93: SH2-like [55549] (1 superfamily)
3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flanked by two helices
Superfamily d.93.1: SH2 domain [55550] (2 families)
Family d.93.1.1: SH2 domain [55551] (35 proteins)
Pfam PF00017
Protein Phosphatidylinositol 3-kinase, p85-alpha subunit [55569] (3 species)

Cow (Bos taurus) [TaxId:9913] [55570] (7 PDB entries)
1. Domain for 1bfi:
  - Domain d1bfia_: 1bfi A: [40499]
    C-terminal SH2 domain
2. Domain for 1bfj:
  - Domain d1bfja_: 1bfj A: [40500]
    C-terminal SH2 domain
3. Domain for 1oo3:
  - Domain d1oo3a_: 1oo3 A: [87184]
    N-terminal SH2 domain
    mutant
4. Domain for 1oo4:
  - Domain d1oo4a_: 1oo4 A: [87185]
    N-terminal SH2 domain; complexed to a peptide derived from PDGFR (chain B)
    mutant
5. Domain for 1qad:
  - Domain d1qada_: 1qad A: [40498]
    C-terminal SH2 domain
6. Domain for 2pna:
  - Domain d2pnaa_: 2pna A: [40501]
    N-terminal SH2 domain
7. Domain for 2pnb:
  - Domain d2pnba_: 2pnb A: [40502]
    N-terminal SH2 domain
Human (Homo sapiens) [TaxId:9606] [55571] (2 PDB entries)
1. Domain for 1h9o:
  - Domain d1h9oa_: 1h9o A: [60837]
    complexed with a tyr751 phosphopeptide from the pdgf receptor
2. Domain for 1pic:
  - Domain d1pica_: 1pic A: [40503]
Norway rat (Rattus norvegicus) [TaxId:10116] [55572] (2 PDB entries)
1. Domain for 1fu5:
  - Domain d1fu5a_: 1fu5 A: [40505]
2. Domain for 1fu6:
  - Domain d1fu6a_: 1fu6 A: [40504]

Timeline for Protein Phosphatidylinositol 3-kinase, p85-alpha subunit from d.93.1.1: SH2 domain:

Protein Phosphatidylinositol 3-kinase, p85-alpha subunit from d.93.1.1: SH2 domain first appeared (with stable ids) in SCOP 1.55
Protein Phosphatidylinositol 3-kinase, p85-alpha subunit from d.93.1.1: SH2 domain appears in SCOPe 2.06
Protein Phosphatidylinositol 3-kinase, p85-alpha subunit from d.93.1.1: SH2 domain appears in the current release, SCOPe 2.08