Lineage for Family d.93.1.1: SH2 domain

  1. Root: SCOPe 2.04
  2. 1631855Class d: Alpha and beta proteins (a+b) [53931] (380 folds)
  3. 1661863Fold d.93: SH2-like [55549] (1 superfamily)
    3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flanked by two helices
  4. 1661864Superfamily d.93.1: SH2 domain [55550] (2 families) (S)
  5. 1661865Family d.93.1.1: SH2 domain [55551] (35 proteins)
    Pfam PF00017

Proteins:

  1. 1661866Abl tyrosine kinase [55581] (2 species)
    1. 1661867Species Human (Homo sapiens) [TaxId:9606] [55582] (2 PDB entries)
    2. 1661871Species Mouse (Mus musculus) [TaxId:10090] [89998] (1 PDB entry)
  2. 1661873Adaptor protein Aps [103139] (1 species)
  3. 1661879Beta-chimaerin, N-terminal domain [118052] (1 species)
    includes N-terminal tail and the linker to the next domain
  4. 1661882c-src tyrosine kinase [55556] (3 species)
    1. Species Chicken (Gallus gallus) [TaxId:9031] [55558] (4 PDB entries)
    2. 1661889Species Human (Homo sapiens) [TaxId:9606] [55557] (46 PDB entries)
    3. 1661943Species Rous sarcoma virus [TaxId:11886] [69782] (12 PDB entries)
  5. 1661964Carboxyl-terminal src kinase (csk) [75498] (1 species)
  6. 1661972Cbl [55587] (1 species)
  7. 1661989Crk proto-oncogen [82741] (1 species)
  8. 1661993Csk homologous kinase Chk [64345] (1 species)
  9. 1661997Ews/fli1 activated transcript 2, Eat2 [89999] (1 species)
  10. 1662000GRB2-related adaptor protein 2 (MONA, GRID) [111086] (1 species)
  11. 1662012Growth factor receptor-bound protein 10, GRB10 [89994] (1 species)
  12. 1662016Growth factor receptor-bound protein 2 (GRB2) [55563] (1 species)
  13. 1662084Growth factor receptor-bound protein 7 [103135] (1 species)
  14. 1662092Hematopoietic SH2 domain containing protein HSH2D [143623] (1 species)
  15. 1662095Hemopoetic cell kinase Hck [55565] (1 species)
  16. 1662130Itk/tsk protein tyrosine kinase [82743] (1 species)
  17. 1662140P55 Blk protein tyrosine kinase [55579] (1 species)
  18. 1662144p56-lck tyrosine kinase [55552] (1 species)
  19. 1662165Phosphatidylinositol 3-kinase, p85-alpha subunit [55569] (3 species)
    1. 1662166Species Cow (Bos taurus) [TaxId:9913] [55570] (7 PDB entries)
    2. 1662174Species Human (Homo sapiens) [TaxId:9606] [55571] (2 PDB entries)
    3. 1662177Species Norway rat (Rattus norvegicus) [TaxId:10116] [55572] (2 PDB entries)
  20. 1662180Phospholipase C-gamma-1 [55577] (2 species)
    1. 1662181Species Cow (Bos taurus) [TaxId:9913] [55578] (3 PDB entries)
    2. 1662185Species Norway rat (Rattus norvegicus) [TaxId:10116] [226824] (2 PDB entries)
  21. 1662190Proto-oncogen tyrosine kinase [55573] (1 species)
  22. 1662194Shc adaptor protein [55567] (1 species)
  23. 1662198STAT homologue [103137] (1 species)
  24. 1662202STAT-1 [55583] (1 species)
  25. 1662205STAT3b [55585] (1 species)
  26. 1662208Suppressor of cytokine signaling 2, SOCS-2 [160562] (1 species)
  27. 1662211Suppressor of cytokine signaling 4, SOCS-4 [160564] (1 species)
  28. 1662214Syk tyrosine kinase [55575] (1 species)
  29. 1662230The Xlp protein Sap [55591] (1 species)
  30. 1662242Tyrosine kinase Fyn [55559] (1 species)
  31. 1662248Tyrosine phoshatase shp-2 [55589] (1 species)
  32. 1662254Tyrosine phosphatase Syp [55561] (1 species)
  33. 1662261Tyrosine-protein kinase 6 (Breast tumor kinase, Brk) [111084] (1 species)
  34. 1662264Tyrosine-protein kinase zap-70 [89996] (1 species)
  35. 1662270automated matches [190202] (2 species)
    not a true protein
    1. 1662271Species Human (Homo sapiens) [TaxId:9606] [186949] (11 PDB entries)
    2. 1662286Species Mouse (Mus musculus) [TaxId:10090] [187800] (4 PDB entries)

More info for Family d.93.1.1: SH2 domain

Timeline for Family d.93.1.1: SH2 domain: