Lineage for Family d.92.1.5: Neurolysin-like

  1. Root: SCOPe 2.05
  2. 1886641Class d: Alpha and beta proteins (a+b) [53931] (381 folds)
  3. 1917420Fold d.92: Zincin-like [55485] (2 superfamilies)
    contains mixed beta sheet with connection over free side of the sheet
  4. 1917421Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (18 families) (S)
  5. 1917605Family d.92.1.5: Neurolysin-like [55505] (5 proteins)
    combines M2, M3 and M32 families of metalloproteases
    the N-terminal half of the structure is multihelical; the C-terminal half contains the thermolysin-like catalytic domain

Proteins:

  1. 1917606Angiotensin converting enzyme 2, ACE2 [103125] (2 species)
    1. 1917607Species Human (Homo sapiens) [TaxId:9606] [103126] (5 PDB entries)
    2. 1917616Species Paguma larvata [188486] (5 PDB entries)
  2. 1917627Angiotensin converting enzyme, ACE [82733] (2 species)
    M2 family member; overall fold is similar to that of neurolysin but is less elaborated
    1. 1917628Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [89991] (3 PDB entries)
    2. 1917635Species Human (Homo sapiens) [TaxId:9606] [82734] (11 PDB entries)
      Uniprot P22966
  3. 1917647Neurolysin (endopeptidase 24.16, thimet oligopeptidase) [55506] (2 species)
    M3 family member; the thermolysin-like catalytic domain consists of residues 352-674
    1. 1917648Species Human (Homo sapiens) [TaxId:9606] [111081] (2 PDB entries)
      Uniprot P52888
    2. 1917651Species Norway rat (Rattus norvegicus) [TaxId:10116] [55507] (1 PDB entry)
  4. 1917653Thermostable carboxypeptidase 1 [82731] (1 species)
    M32 (Taq) family member; overall fold is similar to that of neurolysin but is less elaborated
  5. 1917661automated matches [190340] (3 species)
    not a true protein
    1. 1917662Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [189355] (16 PDB entries)
    2. 1917679Species Human (Homo sapiens) [TaxId:9606] [187164] (8 PDB entries)
    3. 1917688Species Norway rat (Rattus norvegicus) [TaxId:10116] [187944] (2 PDB entries)

More info for Family d.92.1.5: Neurolysin-like

Timeline for Family d.92.1.5: Neurolysin-like: