Lineage for Family d.92.1.5: Neurolysin-like

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2528985Fold d.92: Zincin-like [55485] (2 superfamilies)
    contains mixed beta sheet with connection over free side of the sheet
  4. 2528986Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (18 families) (S)
  5. 2529230Family d.92.1.5: Neurolysin-like [55505] (5 proteins)
    combines M2, M3 and M32 families of metalloproteases
    the N-terminal half of the structure is multihelical; the C-terminal half contains the thermolysin-like catalytic domain

Proteins:

  1. 2529231Angiotensin converting enzyme 2, ACE2 [103125] (1 species)
  2. 2529251Angiotensin converting enzyme, ACE [82733] (2 species)
    M2 family member; overall fold is similar to that of neurolysin but is less elaborated
    1. 2529252Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [89991] (3 PDB entries)
    2. 2529259Species Human (Homo sapiens) [TaxId:9606] [82734] (11 PDB entries)
      Uniprot P22966
  3. 2529271Neurolysin (endopeptidase 24.16, thimet oligopeptidase) [55506] (2 species)
    M3 family member; the thermolysin-like catalytic domain consists of residues 352-674
    1. 2529272Species Human (Homo sapiens) [TaxId:9606] [111081] (2 PDB entries)
      Uniprot P52888
    2. 2529275Species Norway rat (Rattus norvegicus) [TaxId:10116] [55507] (1 PDB entry)
  4. 2529277Thermostable carboxypeptidase 1 [82731] (1 species)
    M32 (Taq) family member; overall fold is similar to that of neurolysin but is less elaborated
  5. 2529285automated matches [190340] (4 species)
    not a true protein
    1. 2529286Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [189355] (16 PDB entries)
    2. 2529303Species Human (Homo sapiens) [TaxId:9606] [187164] (11 PDB entries)
    3. 2529312Species Norway rat (Rattus norvegicus) [TaxId:10116] [187944] (2 PDB entries)
    4. 3076803Species Anopheles gambiae [TaxId:7165] [376865] (2 PDB entries)

More info for Family d.92.1.5: Neurolysin-like

Timeline for Family d.92.1.5: Neurolysin-like: