Lineage for Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain

  1. Root: SCOP 1.75
  2. 849709Class d: Alpha and beta proteins (a+b) [53931] (376 folds)
  3. 867614Fold d.92: Zincin-like [55485] (2 superfamilies)
    contains mixed beta sheet with connection over free side of the sheet
  4. 867615Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (17 families) (S)


  1. 867616d.92.1.1: Zinc protease [55487] (1 protein)
    single domain
  2. 867621d.92.1.2: Thermolysin-like [55490] (4 proteins)
    includes alpha-helical C-terminal domain characteristic for the family
  3. 867694d.92.1.3: Leishmanolysin [55499] (1 protein)
  4. 867698d.92.1.4: Neutral endopeptidase (neprilysin) [55502] (1 protein)
  5. 867707d.92.1.5: Neurolysin-like [55505] (4 proteins)
    combines M2, M3 and M32 families of metalloproteases
    the N-terminal half of the structure is multihelical; the C-terminal half contains the thermolysin-like catalytic domain
  6. 867741d.92.1.6: Serralysin-like metalloprotease, catalytic (N-terminal) domain [55508] (1 protein)
    characteristic HEXXHXXGXXH motif and Met located near C-terminus
  7. 867767d.92.1.7: Clostridium neurotoxins, catalytic domain [55512] (1 protein)
  8. 867814d.92.1.8: Astacin [55516] (1 protein)
  9. 867825d.92.1.9: Reprolysin-like [55519] (2 proteins)
    Pfam PF01421
  10. 867857d.92.1.10: TNF-alpha converting enzyme, TACE, catalytic domain [55525] (1 protein)
  11. 867875d.92.1.11: Matrix metalloproteases, catalytic domain [55528] (13 proteins)
  12. 868114d.92.1.12: Fungal zinc peptidase [64335] (1 protein)
    single domain with insertions in the common fold
  13. 868124d.92.1.13: Leukotriene A4 hydrolase catalytic domain [64338] (1 protein)
    adopts thermolysin-like fold
  14. 868142d.92.1.14: Anthrax toxin lethal factor, N- and C-terminal domains [69775] (1 protein)
  15. 868176d.92.1.15: Predicted metal-dependent hydrolase [103132] (3 proteins)
    Pfam PF02130; UPF0054; COG0319; MMP-like fold with a different sequence motif in the putative active site
  16. 868189d.92.1.16: Caur0242-like [160552] (1 protein)
    Pfam PF10103; DUF2342; there is a characteristic HExxH motif but no metal ion bound to it in the first structure.
  17. 868193d.92.1.17: TTHA0227-like [160555] (2 proteins)
    PF06262; DUF1025; minimal zincin fold that retains 3-stranded mixed beta-sheet and contains HExxH motif in the C-terminal helix; no metal ion bound to this motif is observed in the first determined structures

More info for Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain

Timeline for Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain: