SCOP 1.75: Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain

Lineage for Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain

1. Root: SCOP 1.75

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (17 families)

Families:

1. d.92.1.1: Zinc protease [55487] (1 protein)
   single domain

2. d.92.1.2: Thermolysin-like [55490] (4 proteins)
   includes alpha-helical C-terminal domain characteristic for the family

3. d.92.1.3: Leishmanolysin [55499] (1 protein)

4. d.92.1.4: Neutral endopeptidase (neprilysin) [55502] (1 protein)

5. d.92.1.5: Neurolysin-like [55505] (4 proteins)
   combines M2, M3 and M32 families of metalloproteases
   the N-terminal half of the structure is multihelical; the C-terminal half contains the thermolysin-like catalytic domain

6. d.92.1.6: Serralysin-like metalloprotease, catalytic (N-terminal) domain [55508] (1 protein)
   characteristic HEXXHXXGXXH motif and Met located near C-terminus

7. d.92.1.7: Clostridium neurotoxins, catalytic domain [55512] (1 protein)

8. d.92.1.8: Astacin [55516] (1 protein)

9. d.92.1.9: Reprolysin-like [55519] (2 proteins)
   Pfam PF01421

10. d.92.1.10: TNF-alpha converting enzyme, TACE, catalytic domain [55525] (1 protein)

11. d.92.1.11: Matrix metalloproteases, catalytic domain [55528] (13 proteins)

12. d.92.1.12: Fungal zinc peptidase [64335] (1 protein)
    single domain with insertions in the common fold

13. d.92.1.13: Leukotriene A4 hydrolase catalytic domain [64338] (1 protein)
    adopts thermolysin-like fold

14. d.92.1.14: Anthrax toxin lethal factor, N- and C-terminal domains [69775] (1 protein)

15. d.92.1.15: Predicted metal-dependent hydrolase [103132] (3 proteins)
    Pfam PF02130; UPF0054; COG0319; MMP-like fold with a different sequence motif in the putative active site

16. d.92.1.16: Caur0242-like [160552] (1 protein)
    Pfam PF10103; DUF2342; there is a characteristic HExxH motif but no metal ion bound to it in the first structure.

17. d.92.1.17: TTHA0227-like [160555] (2 proteins)
    PF06262; DUF1025; minimal zincin fold that retains 3-stranded mixed beta-sheet and contains HExxH motif in the C-terminal helix; no metal ion bound to this motif is observed in the first determined structures

More info for Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain

Timeline for Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain:

• Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain first appeared (with stable ids) in SCOP 1.55
  
• Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain appears in SCOP 1.73
  
• Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain appears in SCOPe 2.01
  
• Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain appears in the current release, SCOPe 2.08, called Superfamily d.92.1: Metalloproteases ('zincins'), catalytic domain