SCOPe 2.01: Superfamily d.58.18: ACT-like

Lineage for Superfamily d.58.18: ACT-like

1. Root: SCOPe 2.01

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.58: Ferredoxin-like [54861] (59 superfamilies)
   alpha+beta sandwich with antiparallel beta-sheet; (beta-alpha-beta)x2

4. Superfamily d.58.18: ACT-like [55021] (14 families)
   regulatory domain linked to a wide range of metabolic enzymes

Families:

1. d.58.18.1: Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain [55022] (1 protein)

2. d.58.18.2: Allosteric threonine deaminase C-terminal domain [55025] (1 protein)

3. d.58.18.3: Phenylalanine metabolism regulatory domain [55028] (2 proteins)

4. d.58.18.4: Nickel responsive regulator NikR, C-terminal domain [102999] (1 protein)

5. d.58.18.5: Glycine cleavage system transcriptional repressor [110980] (1 protein)
   tandem repeat of two ACT-like domains; swapped domain dimer

6. d.58.18.6: IlvH-like [143376] (1 protein)
   Duplication: tandem repeat of two ACT-like domains; dimer, the N- and C-terminal domains have different dimerisation modes

7. d.58.18.7: SP0238-like [143381] (1 protein)
   stand-alone protein; dimer, the dimerization interface is formed by parallel packing of the subunit beta-sheets

8. d.58.18.8: Atu0741-like [143384] (1 protein)
   duplication: tandem repeat of two ACT-like domains; contains strand invasion of extra N-terminal strand into the C-terminal domain beta-sheet; dimerizes with the formation of orthogonally packed intersubunit beta-sheets

9. d.58.18.9: VC0802-like [143387] (1 protein)
   duplication: tandem repeat of two ACT-like domains; contains circular permutation (the C-terminal strand replacement with extra N-terminal strand); dimerizes with the formation of orthogonally packed intersubunit beta-sheets

10. d.58.18.10: Aspartokinase allosteric domain-like [143390] (1 protein)
    duplication: tandem repeat of two ACT-like domains; similar subunit and oligomeric structures to the VC0802-like family

11. d.58.18.11: BT0572-like [143395] (1 protein)
    duplication: tandem repeat of two ACT-like domains; dimerizes with the formation of orthogonally packed intersubunit beta-sheets

12. d.58.18.12: AF1403 N-terminal domain-like [143398] (1 protein)
    dimerizes with the formation of a single intersubunit beta-sheet

13. d.58.18.13: NIL domain-like [160322] (2 proteins)
    Pfam PF09383

14. d.58.18.14: TM1266-like [160329] (2 proteins)
    PfamB PB015436; stand-alone tetrameric protein; there are single beta-sheet dimers, whose beta-sheets are packed in parallel fasion in the tetramer

More info for Superfamily d.58.18: ACT-like

Timeline for Superfamily d.58.18: ACT-like:

• Superfamily d.58.18: ACT-like first appeared (with stable ids) in SCOP 1.55, called Superfamily d.58.18: Regulatory domain in the aminoacid metabolism
  
• Superfamily d.58.18: ACT-like appears in SCOP 1.75
  
• Superfamily d.58.18: ACT-like appears in SCOPe 2.02
  
• Superfamily d.58.18: ACT-like appears in the current release, SCOPe 2.08