SCOPe 2.07: Family d.51.1.1: Eukaryotic type KH-domain (KH-domain type I)

Lineage for Family d.51.1.1: Eukaryotic type KH-domain (KH-domain type I)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.51: Eukaryotic type KH-domain (KH-domain type I) [54790] (1 superfamily)
   beta-alpha(2)-beta(2)-alpha; 2 layers: alpha/beta

4. Superfamily d.51.1: Eukaryotic type KH-domain (KH-domain type I) [54791] (2 families)
   Prokaryotic and eukaryotic domains share a KH-motif but have different topologies

5. Family d.51.1.1: Eukaryotic type KH-domain (KH-domain type I) [54792] (17 proteins)
   an RNA-binding domain

Proteins:

1. Exosome complex RNA-binding protein 1, ECR1 [160229] (3 species)

   1. Species Aeropyrum pernix [TaxId:56636] [160231] (1 PDB entry)
      Uniprot Q9YC02 148-234

   2. Species Archaeoglobus fulgidus [TaxId:2234] [160230] (1 PDB entry)
      Uniprot O29758 136-219

   3. Species Sulfolobus solfataricus [TaxId:2287] [160232] (4 PDB entries)
      Uniprot Q9UXC4 153-221

2. Far upstream binding element, FBP [75418] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [75419] (1 PDB entry)

   2. Species Mouse (Mus musculus) [TaxId:10090] [143219] (2 PDB entries)
      Uniprot Q91WJ8 175-255! Uniprot Q91WJ8 89-168

3. Fragile X mental retardation syndrome related protein 1, FXR1 [143222] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [143223] (1 PDB entry)
     Uniprot P51114 212-289

4. Fragile X protein, KH1 [54799] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [54800] (1 PDB entry)

5. HnRNP K, KH3 [54801] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [54802] (2 PDB entries)

6. Hypothetical protein APE0754 [110927] (1 species)
   duplication: tandem repeat of two KH-1 domains

   • Species Aeropyrum pernix [TaxId:56636] [110928] (1 PDB entry)
     Uniprot Q9YE16

7. Neuro-oncological ventral antigen 1, nova-1, KH3 [54793] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [54794] (1 PDB entry)

8. Neuro-oncological ventral antigen 2, nova-2, KH3 [54795] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [54796] (2 PDB entries)

9. Poly(RC)-binding protein 1 [143224] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [143225] (1 PDB entry)
     Uniprot Q15365 279-348

10. Poly(RC)-binding protein 2 [143220] (1 species)
    contains three KH domains

    • Species Human (Homo sapiens) [TaxId:9606] [143221] (5 PDB entries)
      Uniprot Q15366 11-81

11. Quaking protein A (Xqua) [143226] (1 species)

    • Species African clawed frog (Xenopus laevis) [TaxId:8355] [143227] (1 PDB entry)
      Uniprot Q32NN2 82-215

12. Ribosomal RNA-processing protein 4, RRP4 [160227] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [160228] (1 PDB entry)
      Uniprot Q13868 168-293

13. Ribosomal RNA-processing protein 40, RRP40 [160233] (2 species)

    1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [160234] (1 PDB entry)
       Uniprot Q08285 152-236

    2. Species Human (Homo sapiens) [TaxId:9606] [160235] (1 PDB entry)
       Uniprot Q9NQT5 196-275

14. RNA splicing factor 1 [69699] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [69700] (1 PDB entry)

15. Tudor and KH domain containing protein, Tdrkh [117912] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [117913] (1 PDB entry)
      Uniprot Q80VL1 118-208

16. Vigilin [54797] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [54798] (8 PDB entries)

17. automated matches [195910] (2 species)
    not a true protein

    1. Species Human (Homo sapiens) [TaxId:9606] [195911] (4 PDB entries)

    2. Species Nematode (Caenorhabditis elegans) [TaxId:6239] [256433] (1 PDB entry)

More info for Family d.51.1.1: Eukaryotic type KH-domain (KH-domain type I)

Timeline for Family d.51.1.1: Eukaryotic type KH-domain (KH-domain type I):

• Family d.51.1.1: Eukaryotic type KH-domain (KH-domain type I) first appeared (with stable ids) in SCOP 1.55, called Family d.51.1.1: KH-domain
  
• Family d.51.1.1: Eukaryotic type KH-domain (KH-domain type I) appears in SCOPe 2.06
  
• Family d.51.1.1: Eukaryotic type KH-domain (KH-domain type I) appears in the current release, SCOPe 2.08