Lineage for Protein: FK-506 binding protein (FKBP12), an immunophilin

  1. Root: SCOP 1.75
  2. 849709Class d: Alpha and beta proteins (a+b) [53931] (376 folds)
  3. 857507Fold d.26: FKBP-like [54533] (3 superfamilies)
    core: beta(2)-alpha-beta(2); antiparallel beta-sheet
  4. 857508Superfamily d.26.1: FKBP-like [54534] (3 families) (S)
  5. 857509Family d.26.1.1: FKBP immunophilin/proline isomerase [54535] (16 proteins)
  6. 857520Protein FK-506 binding protein (FKBP12), an immunophilin [54536] (2 species)
    cis-trans prolyl-isomerase

Species:

  1. 857521Cow (Bos taurus) [TaxId:9913] [54538] (2 PDB entries)
    1. Domain for 1fkk:
    2. Domain for 1fkl:
  2. 857524Human (Homo sapiens) [TaxId:9606] [54537] (33 PDB entries)
    1. Domains for 1a7x:
      1. 857551Domain d1a7xa_: 1a7x A: [38405]
      2. 857552Domain d1a7xb_: 1a7x B: [38406]
        complexed with fka
    2. Domains for 1b6c:
      1. 857562Domain d1b6ca_: 1b6c A: [38413]
        Other proteins in same PDB: d1b6cb_, d1b6cd_, d1b6cf_, d1b6ch_
      2. 857563Domain d1b6cc_: 1b6c C: [38414]
        Other proteins in same PDB: d1b6cb_, d1b6cd_, d1b6cf_, d1b6ch_
      3. 857564Domain d1b6ce_: 1b6c E: [38415]
        Other proteins in same PDB: d1b6cb_, d1b6cd_, d1b6cf_, d1b6ch_
      4. 857565Domain d1b6cg_: 1b6c G: [38416]
        Other proteins in same PDB: d1b6cb_, d1b6cd_, d1b6cf_, d1b6ch_
        complexed with so4
    3. Domain for 1bkf:
    4. Domains for 1bl4:
      1. 857543Domain d1bl4a_: 1bl4 A: [38393]
      2. 857544Domain d1bl4b_: 1bl4 B: [38394]
        complexed with ap1; mutant
    5. Domains for 1d6o:
      1. 857537Domain d1d6oa_: 1d6o A: [38391]
      2. 857538Domain d1d6ob_: 1d6o B: [38392]
        complexed with nh4, so4
    6. Domains for 1d7h:
      1. 857545Domain d1d7ha_: 1d7h A: [38398]
      2. 857546Domain d1d7hb_: 1d7h B: [38399]
        complexed with dms, nh4, so4
    7. Domains for 1d7i:
      1. 857547Domain d1d7ia_: 1d7i A: [38396]
      2. 857548Domain d1d7ib_: 1d7i B: [38397]
        complexed with dss, nh4, so4
    8. Domains for 1d7j:
      1. 857531Domain d1d7ja_: 1d7j A: [38389]
      2. 857532Domain d1d7jb_: 1d7j B: [38390]
        complexed with buq, nh4, so4
    9. Domains for 1eym:
      1. 857553Domain d1eyma_: 1eym A: [38403]
      2. 857554Domain d1eymb_: 1eym B: [38404]
        mutant
    10. Domain for 1f40:
    11. Domain for 1fap:
    12. Domain for 1fkb:
    13. Domain for 1fkd:
    14. Domain for 1fkf:
    15. Domain for 1fkg:
    16. Domain for 1fkh:
    17. Domains for 1fki:
      1. 857555Domain d1fkia_: 1fki A: [38401]
      2. 857556Domain d1fkib_: 1fki B: [38402]
        complexed with sb1
    18. Domain for 1fkj:
    19. Domain for 1fkr:
    20. Domain for 1fks:
    21. Domain for 1fkt:
    22. Domain for 1j4h:
    23. Domain for 1j4i:
    24. Domains for 1j4r:
      1. 857540Domain d1j4ra_: 1j4r A: [66389]
      2. 857541Domain d1j4rb_: 1j4r B: [66390]
      3. 857542Domain d1j4rd_: 1j4r D: [66391]
        complexed with 001, gol, so4
    25. Domain for 1nsg:
    26. Domains for 1qpf:
      1. 857559Domain d1qpfa_: 1qpf A: [38411]
      2. 857560Domain d1qpfd_: 1qpf D: [38412]
        complexed with 858, b7g
    27. Domains for 1qpl:
      1. 857566Domain d1qpla_: 1qpl A: [38417]
      2. 857567Domain d1qplc_: 1qpl C: [38418]
        complexed with 587
    28. Domain for 2dg3:
    29. Domain for 2fap:
    30. Domain for 2fke:
    31. Domain for 2ppn:
    32. Domain for 3fap:
    33. Domain for 4fap:

More info for Protein FK-506 binding protein (FKBP12), an immunophilin from d.26.1.1: FKBP immunophilin/proline isomerase

Timeline for Protein FK-506 binding protein (FKBP12), an immunophilin from d.26.1.1: FKBP immunophilin/proline isomerase: