SCOP 1.75: Family d.15.1.5: Ras-binding domain, RBD

Lineage for Family d.15.1.5: Ras-binding domain, RBD

1. Root: SCOP 1.75

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.15: beta-Grasp (ubiquitin-like) [54235] (14 superfamilies)
   core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

4. Superfamily d.15.1: Ubiquitin-like [54236] (8 families)

5. Family d.15.1.5: Ras-binding domain, RBD [54263] (13 proteins)
   contains Pfam PF00788 and Pfam PF02196

Proteins:

1. A-Raf proto-oncogene serine/threonine-protein kinase [142968] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [142969] (1 PDB entry)
     Uniprot P10398 19-91

2. Afadin [142964] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [142965] (1 PDB entry)
     Uniprot Q9QZQ1 246-348
     The FHA domain structure is also known (PDB 1wln)

3. c-Raf1 RBD [54264] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [54265] (3 PDB entries)

   2. Species Rat (Rattus norvegicus) [TaxId:10116] [54266] (1 PDB entry)

4. Growth factor receptor-bound protein 7, GRB-7 [117823] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [117824] (1 PDB entry)
     Uniprot Q14451 100-186

5. Phoshoinositide 3-kinase (PI3K) [54274] (2 species)
   includes parts of the flanking linkers

   1. Species Human (Homo sapiens) [TaxId:9606] [54276] (3 PDB entries)

   2. Species Pig (Sus scrofa) [TaxId:9823] [54275] (5 PDB entries)

6. Phospholipase C-epsilon-1 [142966] (1 species)
   contains several Ras-binding domains; some are 'hidden' in the sequence

   • Species Human (Homo sapiens) [TaxId:9606] [142967] (3 PDB entries)
     Uniprot Q9P212 2006-2114! Uniprot Q9P212 2131-2246! Uniprot Q9P212 2134-2239

7. Protein kinase byr2 [69662] (1 species)

   • Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [69663] (2 PDB entries)

8. Ral guanosine-nucleotide exchange factor, RalGDS [54267] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [54269] (3 PDB entries)

   2. Species Rat (Rattus norvegicus) [TaxId:10116] [54268] (2 PDB entries)

9. RalGDS-like factor, Rlf [54270] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [54271] (1 PDB entry)

10. Rap guanine nucleotide exchange factor 5, RapGEF5 [117825] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [117826] (1 PDB entry)
      Uniprot Q92565 241-331

11. Ras association domain-containing protein 8 [142962] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [142963] (1 PDB entry)
      Uniprot Q8NHQ8 1-83

12. Regulator of G-protein signaling 14, RGS14 [117821] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [117822] (1 PDB entry)
      Uniprot P97492 366-456

13. Rgl [54272] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [54273] (1 PDB entry)

More info for Family d.15.1.5: Ras-binding domain, RBD

Timeline for Family d.15.1.5: Ras-binding domain, RBD:

• Family d.15.1.5: Ras-binding domain, RBD first appeared (with stable ids) in SCOP 1.55
  
• Family d.15.1.5: Ras-binding domain, RBD appears in SCOP 1.73
  
• Family d.15.1.5: Ras-binding domain, RBD appears in SCOPe 2.01
  
• Family d.15.1.5: Ras-binding domain, RBD appears in the current release, SCOPe 2.08