SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family d.13.1.1: HIT (HINT, histidine triad) family of protein kinase-interacting proteins

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2157128Fold d.13: HIT-like [54196] (2 superfamilies)
    alpha-beta(3)-alpha-beta(2); 3 layers: alpha/beta/alpha
  4. 2157129Superfamily d.13.1: HIT-like [54197] (5 families) (S)
  5. 2157130Family d.13.1.1: HIT (HINT, histidine triad) family of protein kinase-interacting proteins [54198] (8 protein domains)
    Pfam PF01230
    topologically similar to the N-terminal domain of protein kinases

Protein Domains:

  1. 2157131FHIT (fragile histidine triad protein) [54201] (1 species)
  2. 2157141Histidine triad nucleotide-binding protein (HINT) [54199] (2 species)
    1. 2157142Species Human (Homo sapiens) [TaxId:9606] [224916] (3 PDB entries)
    2. 2157149Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [54200] (10 PDB entries)
  3. 2157160Histidine triad protein Mfla2506 [159880] (1 species)
  4. 2157166Hit [117789] (1 species)
  5. 2157173NIT-FHIT fusion protein, C-terminal domain [54205] (1 species)
  6. 2157177Protein kinase C inhibitor-1, PKCI-1 [54203] (1 species)
  7. 2157192Putative hydrolase [117791] (2 species)
    1. 2157193Species Clostridium thermocellum [TaxId:1515] [117792] (1 PDB entry)
      Uniprot Q4CCR3
    2. 2289488Species Ruminiclostridium thermocellum [TaxId:637887] [332789] (1 PDB entry)
  8. 2157196automated matches [191082] (2 species)
    not a true protein
    1. 2157197Species Bacillus anthracis [TaxId:261594] [189022] (1 PDB entry)
    2. 2157202Species Human (Homo sapiens) [TaxId:9606] [189791] (16 PDB entries)

More info for Family d.13.1.1: HIT (HINT, histidine triad) family of protein kinase-interacting proteins

Timeline for Family d.13.1.1: HIT (HINT, histidine triad) family of protein kinase-interacting proteins: