SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Protein: (Pro)cathepsin K

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2154577Fold d.3: Cysteine proteinases [54000] (1 superfamily)
    consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
  4. 2154578Superfamily d.3.1: Cysteine proteinases [54001] (24 families) (S)
    the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet
  5. 2154579Family d.3.1.1: Papain-like [54002] (26 protein domains)
  6. 2154605Protein (Pro)cathepsin K [54028] (3 species)

Species:

  1. 2154606Human (Homo sapiens) [TaxId:9606] [54029] (51 PDB entries)
    Uniprot P43235 116-329 ! Uniprot P43235 115-329
    1. Domain for 1atk:
    2. Domain for 1au0:
    3. Domain for 1au2:
    4. Domain for 1au3:
    5. Domain for 1au4:
    6. Domain for 1ayu:
    7. Domain for 1ayv:
    8. Domain for 1ayw:
    9. Domain for 1bgo:
    10. Domain for 1by8:
    11. Domain for 1mem:
    12. Domains for 1nl6:
      1. 2154659Domain d1nl6a_: 1nl6 A: [80619]
        complexed with 750
      2. 2154660Domain d1nl6b_: 1nl6 B: [80620]
        complexed with 750
    13. Domains for 1nlj:
      1. 2154651Domain d1nlja_: 1nlj A: [80626]
        complexed with 2ca
      2. 2154652Domain d1nljb_: 1nlj B: [80627]
        complexed with 2ca
    14. Domain for 1q6k:
    15. Domain for 1snk:
    16. Domains for 1tu6:
      1. 2154612Domain d1tu6a_: 1tu6 A: [107318]
        complexed with fsp, so4
      2. 2154613Domain d1tu6b_: 1tu6 B: [107319]
        complexed with fsp, so4
    17. Domain for 1u9v:
    18. Domain for 1u9w:
    19. Domain for 1u9x:
    20. Domain for 1vsn:
    21. Domain for 1yk7:
    22. Domain for 1yk8:
    23. Domain for 1yt7:
    24. Domain for 2ato:
    25. Domain for 2aux:
    26. Domain for 2auz:
    27. Domain for 2bdl:
    28. Domain for 2fdz:
    29. Domains for 2ftd:
      1. 2154649Domain d2ftda_: 2ftd A: [134058]
        automated match to d2r6na1
        complexed with ili
      2. 2154650Domain d2ftdb_: 2ftd B: [134059]
        automated match to d2r6na1
        complexed with ili
    30. Domain for 2r6n:
    31. Domain for 3c9e:
    32. Domain for 3kw9:
    33. Domains for 3kwb:
      1. 2154626Domain d3kwbx_: 3kwb X: [199680]
        automated match to d1tu6a_
        complexed with orh
      2. 2154627Domain d3kwby_: 3kwb Y: [191890]
        automated match to d2r6na1
        complexed with orh
    34. Domain for 3kwz:
    35. Domain for 3kx1:
    36. Domain for 3o0u:
    37. Domain for 3o1g:
    38. Domain for 3ovz:
    39. Domain for 4dmx:
    40. Domains for 4dmy:
      1. 2154609Domain d4dmya_: 4dmy A: [192344]
        automated match to d2r6na1
        complexed with 0lc, gol, so4
      2. 2154610Domain d4dmyb_: 4dmy B: [192345]
        automated match to d2r6na1
        complexed with 0lc, gol, so4
    41. Domain for 4n79:
    42. Domain for 4n8w:
    43. Domain for 4x6h:
    44. Domain for 4x6i:
    45. Domain for 4x6j:
    46. Domain for 4yv8:
    47. Domain for 4yva:
    48. Domain for 5jh3:
    49. Domain for 5tdi:
    50. Domain for 5tun:
    51. Domains for 7pck:
      1. 2154654Domain d7pcka_: 7pck A: [37079]
        contains propeptide
      2. 2154655Domain d7pckb_: 7pck B: [37080]
        contains propeptide
      3. 2154656Domain d7pckc_: 7pck C: [37081]
        contains propeptide
      4. 2154657Domain d7pckd_: 7pck D: [37082]
        contains propeptide
  2. 2154662Rabbit (Oryctolagus cuniculus) [TaxId:9986] [142845] (1 PDB entry)
    Uniprot P43236 115-329
  3. 2285440Mus musculus [TaxId:10090] [328741] (1 PDB entry)

More info for Protein (Pro)cathepsin K from d.3.1.1: Papain-like

Timeline for Protein (Pro)cathepsin K from d.3.1.1: Papain-like: