Lineage for Family d.3.1.1: Papain-like

  1. Root: SCOP 1.69
  2. 496776Class d: Alpha and beta proteins (a+b) [53931] (279 folds)
  3. 498098Fold d.3: Cysteine proteinases [54000] (1 superfamily)
    consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
  4. 498099Superfamily d.3.1: Cysteine proteinases [54001] (11 families) (S)
    the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet
  5. 498100Family d.3.1.1: Papain-like [54002] (23 proteins)

Proteins:

  1. 498101(Pro)cathepsin B [54022] (3 species)
    1. 498102Species Cow (Bos taurus) [TaxId:9913] [54025] (3 PDB entries)
    2. 498106Species Human (Homo sapiens) [TaxId:9606] [54023] (6 PDB entries)
    3. 498117Species Rat (Rattus norvegicus) [TaxId:10116] [54024] (4 PDB entries)
  2. 498126(Pro)cathepsin K [54028] (1 species)
  3. 498151(Pro)cathepsin L [54026] (1 species)
  4. 498159(Pro)cathepsin S [82566] (1 species)
  5. 498166(Pro)cathepsin V [64202] (1 species)
  6. 498170(Pro)cathepsin X [54031] (1 species)
  7. 498176Actinidin [54003] (1 species)
  8. 498180Bleomycin hydrolase [54017] (2 species)
    DNA-binding protease that has more insertions in the papain-like fold
    1. 498181Species Baker's yeast (Saccharomyces cerevisiae), Gal6 [TaxId:4932] [54018] (3 PDB entries)
    2. 498185Species Human (Homo sapiens) [TaxId:9606] [54019] (2 PDB entries)
  9. 498191Caricain (protease omega) [54007] (1 species)
  10. 498198Cathepsin C (dipeptidyl peptidase I), catalytic domain [75330] (2 species)
    1. 498199Species Human (Homo sapiens) [TaxId:9606] [75331] (1 PDB entry)
    2. 498201Species Rat (Rattus norvegicus) [TaxId:10116] [82565] (1 PDB entry)
  11. 498203Cathepsin F [89805] (1 species)
  12. 498207Cathepsin H [81637] (1 species)
    also contains a disulfide-bound minicathepsin H chain
  13. 498218Chymopapain [54009] (1 species)
  14. 498221Cruzain [54020] (1 species)
  15. 498237Ervatamin B [89803] (1 species)
  16. 498240Ervatamin C [102717] (1 species)
  17. 498244Glycyl endopeptidase [54011] (1 species)
  18. 498247Papain [54005] (1 species)
  19. 498267Proline-specific cysteine protease [54013] (1 species)
  20. 498273Staphopain SspB [102721] (1 species)
  21. 498277Staphopain StpA [54033] (1 species)
  22. 498280Streptococcal pyrogenic exotoxin B [54035] (1 species)
  23. 498290Vignain (bean endopeptidase) [102719] (1 species)

More info for Family d.3.1.1: Papain-like

Timeline for Family d.3.1.1: Papain-like: