Lineage for Family d.3.1.1: Papain-like

  1. Root: SCOP 1.63
  2. 251695Class d: Alpha and beta proteins (a+b) [53931] (224 folds)
  3. 252917Fold d.3: Cysteine proteinases [54000] (1 superfamily)
    consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
  4. 252918Superfamily d.3.1: Cysteine proteinases [54001] (9 families) (S)
    the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet
  5. 252919Family d.3.1.1: Papain-like [54002] (19 proteins)

Proteins:

  1. 252920(Pro)cathepsin B [54022] (3 species)
    1. 252921Species Cow (Bos taurus) [TaxId:9913] [54025] (2 PDB entries)
    2. 252924Species Human (Homo sapiens) [TaxId:9606] [54023] (6 PDB entries)
    3. 252935Species Rat (Rattus norvegicus) [TaxId:10116] [54024] (4 PDB entries)
  2. 252944(Pro)cathepsin K [54028] (1 species)
  3. 252965(Pro)cathepsin L [54026] (1 species)
  4. 252973(Pro)cathepsin S [82566] (1 species)
  5. 252976(Pro)cathepsin V [64202] (1 species)
  6. 252980(Pro)cathepsin X [54031] (1 species)
  7. 252986Actinidin [54003] (1 species)
  8. 252990Bleomycin hydrolase [54017] (2 species)
    DNA-binding protease that has more insertions in the papain-like fold
    1. 252991Species Baker's yeast (Saccharomyces cerevisiae), Gal6 [TaxId:4932] [54018] (3 PDB entries)
    2. 252995Species Human (Homo sapiens) [TaxId:9606] [54019] (2 PDB entries)
  9. Calotropin DI [54015] (1 species)
  10. 253004Caricain (protease omega) [54007] (1 species)
  11. 253011Cathepsin C (dipeptidyl peptidase I), catalytic domain [75330] (2 species)
    1. 253012Species Human (Homo sapiens) [TaxId:9606] [75331] (1 PDB entry)
    2. 253014Species Rat (Rattus norvegicus) [TaxId:10116] [82565] (1 PDB entry)
  12. 253016Cathepsin H [81637] (1 species)
    also contains a disulfide-bound minicathepsin H chain
  13. 253027Chymopapain [54009] (1 species)
  14. 253030Cruzain [54020] (1 species)
  15. 253043Glycyl endopeptidase [54011] (1 species)
  16. 253046Papain [54005] (1 species)
  17. 253064Proline-specific cysteine protease [54013] (1 species)
  18. 253070Staphopain [54033] (1 species)
  19. 253073Streptococcal pyrogenic exotoxin B [54035] (1 species)

More info for Family d.3.1.1: Papain-like

Timeline for Family d.3.1.1: Papain-like: