SCOPe 2.08: Family c.95.1.1: Thiolase-related

Lineage for Family c.95.1.1: Thiolase-related

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.95: Thiolase-like [53900] (1 superfamily)
   consists of two similar domains related by pseudo dyad; duplication
   3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32451; strand 5 is antiparallel to the rest

4. Superfamily c.95.1: Thiolase-like [53901] (3 families)

5. Family c.95.1.1: Thiolase-related [53902] (20 proteins)

Proteins:

1. Actinorhodin polyketide putative beta-ketoacyl synthase 1, KasA, C-terminal domain [419011] (1 species)

   • Species Streptomyces coelicolor [TaxId:1902] [419483] (1 PDB entry)
     Uniprot Q02059

2. Actinorhodin polyketide putative beta-ketoacyl synthase 1, KasA, N-terminal domain [419010] (1 species)

   • Species Streptomyces coelicolor [TaxId:1902] [419482] (1 PDB entry)
     Uniprot Q02059

3. Actinorhodin polyketide putative beta-ketoacyl synthase 2, KasB, C-terminal domain [419013] (1 species)

   • Species Streptomyces coelicolor [TaxId:1902] [419485] (1 PDB entry)
     Uniprot Q02062

4. Actinorhodin polyketide putative beta-ketoacyl synthase 2, KasB, N-terminal domain [419012] (1 species)

   • Species Streptomyces coelicolor [TaxId:1902] [419484] (1 PDB entry)
     Uniprot Q02062

5. Beta-ketoacyl-ACP synthase I, C-terminal domain [419015] (2 species)

   1. Species Escherichia coli [TaxId:562] [419487] (19 PDB entries)
      Uniprot P14926

   2. Species Escherichia coli [TaxId:83333] [419575] (2 PDB entries)

6. Beta-ketoacyl-ACP synthase I, N-terminal domain [419014] (2 species)

   1. Species Escherichia coli [TaxId:562] [419486] (19 PDB entries)
      Uniprot P14926

   2. Species Escherichia coli [TaxId:83333] [419574] (2 PDB entries)

7. Beta-ketoacyl-ACP synthase II, C-terminal domain [419017] (6 species)

   1. Species Escherichia coli [TaxId:562] [419489] (4 PDB entries)

   2. Species Pneumococcus (Streptococcus pneumoniae) [TaxId:1313] [419491] (4 PDB entries)

   3. Species Staphylococcus aureus [TaxId:1280] [419493] (1 PDB entry)

   4. Species Synechocystis sp. [TaxId:1143] [419495] (1 PDB entry)

   5. Species Thale cress (Arabidopsis thaliana), mitochondrial isoform [TaxId:3702] [419497] (2 PDB entries)
      Uniprot Q8L3X9

   6. Species Thermus thermophilus [TaxId:274] [419499] (1 PDB entry)

8. Beta-ketoacyl-ACP synthase II, N-terminal domain [419016] (6 species)

   1. Species Escherichia coli [TaxId:562] [419488] (4 PDB entries)

   2. Species Pneumococcus (Streptococcus pneumoniae) [TaxId:1313] [419490] (4 PDB entries)

   3. Species Staphylococcus aureus [TaxId:1280] [419492] (1 PDB entry)

   4. Species Synechocystis sp. [TaxId:1143] [419494] (1 PDB entry)

   5. Species Thale cress (Arabidopsis thaliana), mitochondrial isoform [TaxId:3702] [419496] (2 PDB entries)
      Uniprot Q8L3X9

   6. Species Thermus thermophilus [TaxId:274] [419498] (1 PDB entry)

9. Beta-ketoadipyl CoA thiolase, C-terminal domain [419019] (1 species)

   • Species Thermus thermophilus [TaxId:274] [419501] (1 PDB entry)
     Uniprot Q5SJM1

10. Beta-ketoadipyl CoA thiolase, N-terminal domain [419018] (1 species)

    • Species Thermus thermophilus [TaxId:274] [419500] (1 PDB entry)
      Uniprot Q5SJM1

11. Biosynthetic thiolase, C-terminal domain [419021] (1 species)

    • Species Zoogloea ramigera [TaxId:350] [419503] (16 PDB entries)
      Uniprot P07097

12. Biosynthetic thiolase, N-terminal domain [419020] (1 species)

    • Species Zoogloea ramigera [TaxId:350] [419502] (16 PDB entries)
      Uniprot P07097

13. Fatty oxidation complex beta subunit (3-ketoacyl-CoA thiolase), C-terminal domain [419023] (1 species)

    • Species Pseudomonas fragi [TaxId:296] [419505] (4 PDB entries)
      Uniprot P28790

14. Fatty oxidation complex beta subunit (3-ketoacyl-CoA thiolase), N-terminal domain [419022] (1 species)

    • Species Pseudomonas fragi [TaxId:296] [419504] (4 PDB entries)
      Uniprot P28790

15. Ketoacyl synthase domain from fatty acid synthase (FAS) [419107] (1 species)

    • Species Pig (Sus scrofa) [TaxId:9823] [419621] (1 PDB entry)

16. Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), C-terminal domain [419025] (1 species)

    • Species Saccharopolyspora erythraea [TaxId:1836] [419507] (1 PDB entry)

17. Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), N-terminal domain [419024] (1 species)

    • Species Saccharopolyspora erythraea [TaxId:1836] [419506] (1 PDB entry)

18. Thiolase, C-terminal domain [419027] (1 species)
    topology is similar to the first domain of phosphoglucomutase

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [419509] (2 PDB entries)

19. Thiolase, N-terminal domain [419026] (1 species)
    topology is similar to the first domain of phosphoglucomutase

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [419508] (2 PDB entries)

20. automated matches [231410] (2 species)
    not a true protein

    1. Species Escherichia coli [TaxId:562] [254877] (9 PDB entries)

    2. Species Zoogloea ramigera [TaxId:350] [231411] (6 PDB entries)

More info for Family c.95.1.1: Thiolase-related

Timeline for Family c.95.1.1: Thiolase-related:

• Family c.95.1.1: Thiolase-related first appeared (with stable ids) in SCOP 1.55
  
• Family c.95.1.1: Thiolase-related appears in SCOPe 2.07