SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Protein: Asparaginase type II

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2142620Fold c.88: Glutaminase/Asparaginase [53773] (1 superfamily)
    consists of two non-similar alpha/beta domains, 3 layers (a/b/a) each
    Domain 1 has mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest; left-handed crossover connection between strands 4 and 5
    Domain 2 has parallel beta-sheet of 4 strands, order 1234
  4. 2142621Superfamily c.88.1: Glutaminase/Asparaginase [53774] (2 families) (S)
  5. 2142622Family c.88.1.1: Glutaminase/Asparaginase [53775] (4 protein domains)
    automatically mapped to Pfam PF00710
  6. 2142623Protein Asparaginase type II [53776] (5 species)

Species:

  1. 2142624Erwinia chrysanthemi [TaxId:556] [53779] (8 PDB entries)
    1. Domains for 1hfj:
      1. 2142651Domain d1hfja_: 1hfj A: [35562]
        complexed with so4
      2. 2142652Domain d1hfjc_: 1hfj C: [35563]
        complexed with so4
    2. Domains for 1hfk:
      1. 2142649Domain d1hfka_: 1hfk A: [35560]
        complexed with so4
      2. 2142650Domain d1hfkc_: 1hfk C: [35561]
        complexed with so4
    3. Domains for 1hfw:
      1. 2142637Domain d1hfwa_: 1hfw A: [61012]
        complexed with glu
      2. 2142638Domain d1hfwb_: 1hfw B: [61013]
        complexed with glu
      3. 2142639Domain d1hfwc_: 1hfw C: [61014]
        complexed with glu
      4. 2142640Domain d1hfwd_: 1hfw D: [61015]
        complexed with glu
    4. Domains for 1hg0:
      1. 2142645Domain d1hg0a_: 1hg0 A: [61016]
        complexed with sin
      2. 2142646Domain d1hg0b_: 1hg0 B: [61017]
        complexed with sin
      3. 2142647Domain d1hg0c_: 1hg0 C: [61018]
        complexed with sin
      4. 2142648Domain d1hg0d_: 1hg0 D: [61019]
        complexed with sin
    5. Domains for 1hg1:
      1. 2142641Domain d1hg1a_: 1hg1 A: [61020]
        complexed with das
      2. 2142642Domain d1hg1b_: 1hg1 B: [61021]
        complexed with das
      3. 2142643Domain d1hg1c_: 1hg1 C: [61022]
        complexed with das
      4. 2142644Domain d1hg1d_: 1hg1 D: [61023]
        complexed with das
    6. Domains for 1jsl:
      1. 2142633Domain d1jsla_: 1jsl A: [67233]
        complexed with 1pe, ddo, gol
      2. 2142634Domain d1jslb_: 1jsl B: [67234]
        complexed with 1pe, ddo, gol
      3. 2142635Domain d1jslc_: 1jsl C: [67235]
        complexed with 1pe, ddo, gol
      4. 2142636Domain d1jsld_: 1jsl D: [67236]
        complexed with 1pe, ddo, gol
    7. Domains for 1jsr:
      1. 2142629Domain d1jsra_: 1jsr A: [67237]
        complexed with 1pe, gol, ldo
      2. 2142630Domain d1jsrb_: 1jsr B: [67238]
        complexed with 1pe, gol, ldo
      3. 2142631Domain d1jsrc_: 1jsr C: [67239]
        complexed with 1pe, gol, ldo
      4. 2142632Domain d1jsrd_: 1jsr D: [67240]
        complexed with 1pe, gol, ldo
    8. Domains for 1o7j:
      1. 2142625Domain d1o7ja_: 1o7j A: [81140]
        complexed with edo, gol, so4
      2. 2142626Domain d1o7jb_: 1o7j B: [81141]
        complexed with edo, gol, so4
      3. 2142627Domain d1o7jc_: 1o7j C: [81142]
        complexed with edo, gol, so4
      4. 2142628Domain d1o7jd_: 1o7j D: [81143]
        complexed with edo, gol, so4
  2. 2142653Escherichia coli [TaxId:562] [53777] (7 PDB entries)
    1. Domains for 1ho3:
      1. 2142672Domain d1ho3a_: 1ho3 A: [61101]
        complexed with asp; mutant
      2. 2142673Domain d1ho3b_: 1ho3 B: [61102]
        complexed with asp; mutant
    2. Domains for 1ihd:
      1. 2142674Domain d1ihda_: 1ihd A: [90665]
        mutant
      2. 2142675Domain d1ihdc_: 1ihd C: [90666]
        mutant
    3. Domains for 1jaz:
      1. 2142664Domain d1jaza_: 1jaz A: [90883]
        complexed with zn; mutant
      2. 2142665Domain d1jazb_: 1jaz B: [90884]
        complexed with zn; mutant
    4. Domains for 1jja:
      1. 2142666Domain d1jjaa_: 1jja A: [90891]
        mutant
      2. 2142667Domain d1jjab_: 1jja B: [90892]
        mutant
      3. 2142668Domain d1jjac_: 1jja C: [90893]
        mutant
      4. 2142669Domain d1jjad_: 1jja D: [90894]
        mutant
      5. 2142670Domain d1jjae_: 1jja E: [90895]
        mutant
      6. 2142671Domain d1jjaf_: 1jja F: [90896]
        mutant
    5. Domains for 1nns:
      1. 2142654Domain d1nnsa_: 1nns A: [85910]
        complexed with asp
      2. 2142655Domain d1nnsb_: 1nns B: [85911]
        complexed with asp
    6. Domains for 3eca:
      1. 2142660Domain d3ecaa_: 3eca A: [35554]
        complexed with asp
      2. 2142661Domain d3ecab_: 3eca B: [35555]
        complexed with asp
      3. 2142662Domain d3ecac_: 3eca C: [35556]
        complexed with asp
      4. 2142663Domain d3ecad_: 3eca D: [35557]
        complexed with asp
    7. Domains for 4eca:
      1. 2142656Domain d4ecaa_: 4eca A: [35550]
        mutant
      2. 2142657Domain d4ecab_: 4eca B: [35551]
        mutant
      3. 2142658Domain d4ecac_: 4eca C: [35552]
        mutant
      4. 2142659Domain d4ecad_: 4eca D: [35553]
        mutant
  3. 2142676Vibrio cholerae [TaxId:666] [159797] (2 PDB entries)
    Uniprot Q9KQK3 2-337
    1. Domains for 2h7k:
      1. 2142681Domain d2h7ka_: 2h7k A: [303946]
        automated match to d2ocda1
        complexed with gol
      2. 2142682Domain d2h7kb_: 2h7k B: [303947]
        automated match to d2ocda1
        complexed with gol
      3. 2142683Domain d2h7kc_: 2h7k C: [303948]
        automated match to d2ocda1
        complexed with gol
      4. 2142684Domain d2h7kd_: 2h7k D: [303949]
        automated match to d2ocda1
        complexed with gol
    2. Domains for 2ocd:
      1. 2142677Domain d2ocda1: 2ocd A:2-337 [148723]
        complexed with act, gol
      2. 2142678Domain d2ocdb_: 2ocd B: [148724]
        automated match to d2ocda1
        complexed with act, gol
      3. 2142679Domain d2ocdc_: 2ocd C: [148725]
        automated match to d2ocda1
        complexed with act, gol
      4. 2142680Domain d2ocdd_: 2ocd D: [148726]
        automated match to d2ocda1
        complexed with act, gol
  4. 2142685Wolinella succinogenes [TaxId:844] [53778] (1 PDB entry)
  5. 2289052Wolinella succinogenes [TaxId:273121] [332353] (4 PDB entries)
    1. Domains for 5k3o:
      1. 2289053Domain d5k3ob_: 5k3o B: [332354]
        automated match to d1wsaa_
        complexed with asp
      2. 2289056Domain d5k3od_: 5k3o D: [332357]
        automated match to d1wsaa_
        complexed with asp
      3. 2289120Domain d5k3oa_: 5k3o A: [332421]
        automated match to d1wsaa_
        complexed with asp
      4. 2289137Domain d5k3oc_: 5k3o C: [332438]
        automated match to d1wsaa_
        complexed with asp
    2. Domains for 5k45:
      1. 2289069Domain d5k45a_: 5k45 A: [332370]
        automated match to d1wsaa_
        complexed with glu
      2. 2289097Domain d5k45b_: 5k45 B: [332398]
        automated match to d1wsaa_
        complexed with glu
      3. 2289105Domain d5k45d_: 5k45 D: [332406]
        automated match to d1wsaa_
        complexed with glu
      4. 2289222Domain d5k45c_: 5k45 C: [332523]
        automated match to d1wsaa_
        complexed with glu
    3. Domains for 5k4g:
      1. 2289122Domain d5k4ga_: 5k4g A: [332423]
        Other proteins in same PDB: d5k4gb_, d5k4gd_
        automated match to d1wsaa_
        complexed with asp
      2. 2289221Domain d5k4gc_: 5k4g C: [332522]
        Other proteins in same PDB: d5k4gb_, d5k4gd_
        automated match to d1wsaa_
        complexed with asp
    4. Domains for 5k4h:
      1. 2289054Domain d5k4hb_: 5k4h B: [332355]
        automated match to d1wsaa_
        complexed with glu
      2. 2289055Domain d5k4hf_: 5k4h F: [332356]
        automated match to d1wsaa_
        complexed with glu
      3. 2289063Domain d5k4hc_: 5k4h C: [332364]
        automated match to d1wsaa_
        complexed with glu
      4. 2289065Domain d5k4hh_: 5k4h H: [332366]
        automated match to d1wsaa_
        complexed with glu
      5. 2289091Domain d5k4hd_: 5k4h D: [332392]
        automated match to d1wsaa_
        complexed with glu
      6. 2289123Domain d5k4hg_: 5k4h G: [332424]
        automated match to d1wsaa_
        complexed with glu
      7. 2289138Domain d5k4he_: 5k4h E: [332439]
        automated match to d1wsaa_
        complexed with glu
      8. 2289179Domain d5k4ha_: 5k4h A: [332480]
        automated match to d1wsaa_
        complexed with glu

More info for Protein Asparaginase type II from c.88.1.1: Glutaminase/Asparaginase

Timeline for Protein Asparaginase type II from c.88.1.1: Glutaminase/Asparaginase: