SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family c.79.1.1: Tryptophan synthase beta subunit-like PLP-dependent enzymes

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2139769Fold c.79: Tryptophan synthase beta subunit-like PLP-dependent enzymes [53685] (1 superfamily)
    consists of two similar domains related by pseudo dyad; duplication
    core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 3214
  4. 2139770Superfamily c.79.1: Tryptophan synthase beta subunit-like PLP-dependent enzymes [53686] (2 families) (S)
  5. 2139771Family c.79.1.1: Tryptophan synthase beta subunit-like PLP-dependent enzymes [53687] (9 protein domains)

Protein Domains:

  1. 21397721-aminocyclopropane-1-carboxylate deaminase [53694] (3 species)
    1. 2139773Species Pseudomonas sp., strain ACP [TaxId:306] [110722] (6 PDB entries)
      Uniprot Q00740
    2. 2139798Species Pyrococcus horikoshii [TaxId:53953] [89777] (2 PDB entries)
    3. 2139826Species Yeast (Hansenula saturnus) [TaxId:4906] [53695] (4 PDB entries)
  2. 2139843Cystathionine beta-synthase [64174] (1 species)
    PLP-dependent hemoprotein
  3. 2139857Hypothetical protein C320.14 (SPCC320.14, SPCC330.15c) [142749] (1 species)
  4. 2139860L-serine dehydratase [102668] (2 species)
    1. 2139861Species Human (Homo sapiens) [TaxId:9606] [110721] (1 PDB entry)
      Uniprot P20132
    2. 2139863Species Norway rat (Rattus norvegicus) [TaxId:10116] [102669] (2 PDB entries)
  5. 2139874O-acetylserine sulfhydrylase (Cysteine synthase) [53690] (7 species)
    1. 2139875Species Aeropyrum pernix [TaxId:56636] [142742] (3 PDB entries)
      Uniprot Q9YBL2 1-382
    2. 2139878Species Escherichia coli, isoform B (CysM) [TaxId:562] [142744] (2 PDB entries)
      Uniprot P16703 2-293
    3. 2139881Species Haemophilus influenzae [TaxId:727] [142746] (3 PDB entries)
      Uniprot P45040 2-311
    4. 2139885Species Salmonella typhimurium [TaxId:90371] [53691] (3 PDB entries)
    5. 2139894Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [142745] (2 PDB entries)
      Uniprot P47998 3-322
    6. 2139897Species Thermotoga maritima [TaxId:2336] [75312] (2 PDB entries)
      TM0665
    7. 2139906Species Thermus thermophilus [TaxId:274] [142743] (1 PDB entry)
      Uniprot Q5SLE6 1-302
  6. 2139908Threonine deaminase [53692] (2 species)
    1. 2139909Species Escherichia coli [TaxId:562] [53693] (1 PDB entry)
    2. 2139911Species Thermus thermophilus [TaxId:274] [142747] (1 PDB entry)
      Uniprot Q5SLL4 2-311
  7. 2139913Threonine synthase [64172] (4 species)
    1. 2139914Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [75313] (1 PDB entry)
    2. 2139917Species Escherichia coli [TaxId:562] [142748] (1 PDB entry)
      Uniprot P00934 1-428
    3. 2139919Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [64173] (3 PDB entries)
    4. 2139930Species Thermus thermophilus [TaxId:274] [102667] (6 PDB entries)
  8. 2139947Tryptophan synthase, beta-subunit [53688] (4 species)
    1. 2139948Species Mycobacterium tuberculosis [TaxId:1773] [267796] (2 PDB entries)
    2. 2139953Species Pyrococcus furiosus [TaxId:2261] [142741] (2 PDB entries)
      Uniprot Q8U093 1-386
    3. 2139964Species Salmonella enterica [TaxId:90371] [229810] (5 PDB entries)
    4. 2139970Species Salmonella typhimurium [TaxId:90371] [53689] (44 PDB entries)
  9. 2140010automated matches [190054] (13 species)
    not a true protein
    1. 2140011Species Aeropyrum pernix [TaxId:272557] [195353] (3 PDB entries)
    2. 2140018Species Escherichia coli [TaxId:562] [187621] (3 PDB entries)
    3. 2140022Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [188093] (3 PDB entries)
    4. 2140026Species Haemophilus influenzae [TaxId:727] [189119] (3 PDB entries)
    5. 2140030Species Human (Homo sapiens) [TaxId:9606] [256281] (1 PDB entry)
    6. 2140032Species Pyrococcus furiosus [TaxId:186497] [279274] (5 PDB entries)
    7. 2140047Species Salmonella typhimurium [TaxId:90371] [189633] (13 PDB entries)
    8. 2140068Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [187877] (1 PDB entry)
    9. 2140070Species Thermus thermophilus HB8 [TaxId:300852] [187272] (5 PDB entries)
    10. 2140080Species Thermus thermophilus [TaxId:274] [188788] (1 PDB entry)
    11. 2276758Species Escherichia coli [TaxId:83334] [320059] (2 PDB entries)
    12. 2277862Species Francisella tularensis [TaxId:177416] [321163] (1 PDB entry)
    13. 2284179Species Pyrococcus furiosus [TaxId:2261] [327480] (1 PDB entry)

More info for Family c.79.1.1: Tryptophan synthase beta subunit-like PLP-dependent enzymes

Timeline for Family c.79.1.1: Tryptophan synthase beta subunit-like PLP-dependent enzymes: