SCOPe 2.06: Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases

Lineage for Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins)
   the active site is between the two identical subunits

Proteins:

1. 3-isopropylmalate dehydrogenase, IPMDH [53661] (11 species)

   1. Species Bacillus coagulans [TaxId:1398] [53664] (2 PDB entries)

   2. Species Bacillus sp. [TaxId:1409] [254872] (1 PDB entry)

   3. Species Chimera (Thermus thermophilus) and (Bacillus subtilis) [TaxId:274] [53663] (2 PDB entries)

   4. Species Escherichia coli [TaxId:562] [53667] (1 PDB entry)

   5. Species Mycobacterium tuberculosis [TaxId:1773] [117725] (2 PDB entries)
      Uniprot P95313

   6. Species Salmonella typhimurium [TaxId:90371] [53666] (1 PDB entry)

   7. Species Shewanella benthica [TaxId:43661] [195907] (1 PDB entry)

   8. Species Sulfolobus tokodaii [TaxId:111955] [117724] (1 PDB entry)
      Uniprot P50455

   9. Species Thermotoga maritima [TaxId:2336] [110714] (1 PDB entry)
      Uniprot Q9WZ26

   10. Species Thermus thermophilus [TaxId:274] [53662] (14 PDB entries)

   11. Species Thiobacillus ferrooxidans [TaxId:920] [53665] (1 PDB entry)

2. Isocitrate dehydrogenase, ICDH [53668] (2 species)

   1. Species Bacillus subtilis [TaxId:1423] [64171] (1 PDB entry)

   2. Species Escherichia coli [TaxId:562] [53669] (27 PDB entries)

3. NADP-dependent isocitrate dehydrogenase [82524] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [110715] (18 PDB entries)
      Uniprot O75874

   2. Species Pig (Sus scrofa) [TaxId:9823] [82525] (2 PDB entries)

4. automated matches [190072] (19 species)
   not a true protein

   1. Species Acidithiobacillus thiooxidans [TaxId:930] [187607] (1 PDB entry)

   2. Species Archaeoglobus fulgidus [TaxId:2234] [187335] (1 PDB entry)

   3. Species Bacillus coagulans [TaxId:1398] [186792] (2 PDB entries)

   4. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [225478] (4 PDB entries)

   5. Species Burkholderia pseudomallei [TaxId:28450] [188497] (1 PDB entry)

   6. Species Burkholderia thailandensis [TaxId:271848] [193254] (1 PDB entry)

   7. Species Campylobacter jejuni [TaxId:197] [189804] (2 PDB entries)

   8. Species Escherichia coli K-12 [TaxId:83333] [189313] (1 PDB entry)

   9. Species Escherichia coli [TaxId:562] [193425] (5 PDB entries)

   10. Species Escherichia coli [TaxId:833333] [194427] (1 PDB entry)

   11. Species Human (Homo sapiens) [TaxId:9606] [189131] (7 PDB entries)

   12. Species Mouse (Mus musculus) [TaxId:10090] [187557] (3 PDB entries)

   13. Species Mycobacterium tuberculosis [TaxId:1773] [193947] (1 PDB entry)

   14. Species Shewanella oneidensis [TaxId:211586] [194175] (12 PDB entries)

   15. Species Sinorhizobium meliloti [TaxId:266834] [226269] (1 PDB entry)

   16. Species Sulfolobus acidocaldarius [TaxId:330779] [311781] (1 PDB entry)

   17. Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [256054] (2 PDB entries)

   18. Species Thermus thermophilus HB8 [TaxId:300852] [192453] (1 PDB entry)

   19. Species Thermus thermophilus [TaxId:274] [189081] (6 PDB entries)

More info for Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases

Timeline for Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases:

• Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases first appeared (with stable ids) in SCOP 1.55, called Family c.77.1.1: Isocitrate & isopropylmalate dehydrogenases
  
• Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases appears in SCOPe 2.05
  
• Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases appears in SCOPe 2.07
  
• Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases appears in the current release, SCOPe 2.08