SCOP 1.71: Protein: Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain

Lineage for Protein: Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain

Root: SCOP 1.71
Class c: Alpha and beta proteins (a/b) [51349] (134 folds)
Fold c.71: Dihydrofolate reductases [53596] (1 superfamily)
3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
Superfamily c.71.1: Dihydrofolate reductases [53597] (1 family)
Family c.71.1.1: Dihydrofolate reductases [53598] (3 proteins)
Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain [53610] (2 species)

Species:

Cryptosporidium hominis [TaxId:237895] [102636] (2 PDB entries)
1. Domains for 1qzf:
  1. Domain d1qzfa1: 1qzf A:3-180 [96633]
    Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2
  2. Domain d1qzfb1: 1qzf B:3-180 [96635]
    Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2
  3. Domain d1qzfc1: 1qzf C:3-180 [96637]
    Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2
  4. Domain d1qzfd1: 1qzf D:3-180 [96639]
    Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2
  5. Domain d1qzfe1: 1qzf E:3-180 [96641]
    Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2
    complexed with cb3, fol, ndp, ump
2. Domains for 1sej:
  1. Domain d1seja1: 1sej A:3-180 [105455]
    Other proteins in same PDB: d1seja2, d1sejb2, d1sejc2, d1sejd2, d1seje2
  2. Domain d1sejb1: 1sej B:3-180 [105457]
    Other proteins in same PDB: d1seja2, d1sejb2, d1sejc2, d1sejd2, d1seje2
  3. Domain d1sejc1: 1sej C:3-180 [105459]
    Other proteins in same PDB: d1seja2, d1sejb2, d1sejc2, d1sejd2, d1seje2
  4. Domain d1sejd1: 1sej D:3-180 [105461]
    Other proteins in same PDB: d1seja2, d1sejb2, d1sejc2, d1sejd2, d1seje2
  5. Domain d1seje1: 1sej E:3-180 [105463]
    Other proteins in same PDB: d1seja2, d1sejb2, d1sejc2, d1sejd2, d1seje2
    complexed with f89, ndp, ump
Malaria parasite (Plasmodium falciparum) [TaxId:5833] [88963] (3 PDB entries)
1. Domains for 1j3i:
  1. Domain d1j3ia_: 1j3i A: [84062]
    Other proteins in same PDB: d1j3ic_, d1j3id_
  2. Domain d1j3ib_: 1j3i B: [84063]
    Other proteins in same PDB: d1j3ic_, d1j3id_
    complexed with ndp, ump, wra
2. Domains for 1j3j:
  1. Domain d1j3ja_: 1j3j A: [84066]
    Other proteins in same PDB: d1j3jc_, d1j3jd_
  2. Domain d1j3jb_: 1j3j B: [84067]
    Other proteins in same PDB: d1j3jc_, d1j3jd_
    complexed with cp6, ndp, ump; mutant
3. Domains for 1j3k:
  1. Domain d1j3ka_: 1j3k A: [84070]
    Other proteins in same PDB: d1j3kc_, d1j3kd_
  2. Domain d1j3kb_: 1j3k B: [84071]
    Other proteins in same PDB: d1j3kc_, d1j3kd_
    complexed with ndp, ump, wra; mutant

More info for Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain from c.71.1.1: Dihydrofolate reductases

Timeline for Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain from c.71.1.1: Dihydrofolate reductases:

Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain from c.71.1.1: Dihydrofolate reductases first appeared (with stable ids) in SCOP 1.55, called Protein Bifunctional enzyme dihidrofolate reductase-thymidylate synthase, DFR domain from c.71.1.1: Dihydrofolate reductases
Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain from c.71.1.1: Dihydrofolate reductases appears in SCOP 1.69
Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain from c.71.1.1: Dihydrofolate reductases appears in SCOP 1.73
Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain from c.71.1.1: Dihydrofolate reductases appears in the current release, SCOPe 2.08