SCOP 1.65: Family c.71.1.1: Dihydrofolate reductases

Lineage for Family c.71.1.1: Dihydrofolate reductases

1. Root: SCOP 1.65

2. Class c: Alpha and beta proteins (a/b) [51349] (121 folds)

3. Fold c.71: Dihydrofolate reductases [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductases [53597] (1 family)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (3 proteins)

Proteins:

1. Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain [53610] (1 species)

   • Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [88963] (3 PDB entries)

2. Dihydrofolate reductase, prokaryotic type [53599] (5 species)

   1. Species Escherichia coli [TaxId:562] [53600] (42 PDB entries)

   2. Species Haloferax volcanii [TaxId:2246] [53604] (1 PDB entry)

   3. Species Lactobacillus casei [TaxId:1582] [53601] (6 PDB entries)

   4. Species Mycobacterium tuberculosis [TaxId:1773] [53602] (4 PDB entries)

   5. Species Thermotoga maritima [TaxId:243274] [53603] (2 PDB entries)

3. Dihydrofolate reductases, eukaryotic type [53605] (4 species)

   1. Species Chicken (Gallus gallus) [TaxId:9031] [53606] (8 PDB entries)

   2. Species Fungus (Pneumocystis carinii) [TaxId:4754] [53608] (11 PDB entries)

   3. Species Human (Homo sapiens) [TaxId:9606] [53607] (15 PDB entries)

   4. Species Yeast (Candida albicans) [TaxId:5476] [53609] (9 PDB entries)

More info for Family c.71.1.1: Dihydrofolate reductases

Timeline for Family c.71.1.1: Dihydrofolate reductases:

• Family c.71.1.1: Dihydrofolate reductases first appeared (with stable ids) in SCOP 1.55
  
• Family c.71.1.1: Dihydrofolate reductases appears in SCOP 1.63
  
• Family c.71.1.1: Dihydrofolate reductases appears in SCOP 1.67
  
• Family c.71.1.1: Dihydrofolate reductases appears in the current release, SCOPe 2.08