SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family c.71.1.1: Dihydrofolate reductases

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2136820Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2136821Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2136822Family c.71.1.1: Dihydrofolate reductases [53598] (4 protein domains)

Protein Domains:

  1. 2136823Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain [53610] (2 species)
    1. 2136824Species Cryptosporidium hominis [TaxId:237895] [102636] (3 PDB entries)
      Uniprot Q5CGA3 Q27552
    2. 2136840Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [88963] (5 PDB entries)
  2. 2136851Dihydrofolate reductase, prokaryotic type [53599] (8 species)
    1. 2136852Species Bacteriophage T4 [TaxId:10665] [102635] (1 PDB entry)
    2. 2136854Species Escherichia coli K-12 [TaxId:83333] [187149] (5 PDB entries)
    3. 2136861Species Escherichia coli [TaxId:562] [53600] (78 PDB entries)
    4. 2136962Species Haloferax volcanii [TaxId:2246] [53604] (3 PDB entries)
    5. 2136967Species Lactobacillus casei [TaxId:1582] [53601] (10 PDB entries)
    6. 2136978Species Mycobacterium tuberculosis [TaxId:1773] [53602] (6 PDB entries)
    7. 2136984Species Staphylococcus aureus [TaxId:1280] [188976] (24 PDB entries)
    8. 2137006Species Thermotoga maritima [TaxId:2336] [53603] (2 PDB entries)
  3. 2137011Dihydrofolate reductases, eukaryotic type [53605] (7 species)
    1. 2137012Species Candida glabrata [TaxId:284593] [237803] (4 PDB entries)
    2. 2137021Species Candida glabrata [TaxId:5478] [188672] (1 PDB entry)
    3. 2137024Species Chicken (Gallus gallus) [TaxId:9031] [53606] (8 PDB entries)
    4. 2137033Species Fungus (Pneumocystis carinii) [TaxId:4754] [53608] (25 PDB entries)
    5. 2137059Species Human (Homo sapiens) [TaxId:9606] [53607] (73 PDB entries)
    6. 2137135Species Mouse (Mus musculus) [TaxId:10090] [187727] (6 PDB entries)
    7. 2137142Species Yeast (Candida albicans) [TaxId:5476] [53609] (17 PDB entries)
  4. 2137177automated matches [190514] (11 species)
    not a true protein
    1. 2137178Species Escherichia coli [TaxId:562] [187587] (3 PDB entries)
    2. 2137183Species Human (Homo sapiens) [TaxId:9606] [188894] (2 PDB entries)
    3. 2137186Species Klebsiella pneumoniae [TaxId:1244085] [261371] (2 PDB entries)
    4. 2137192Species Mycobacterium avium [TaxId:1764] [189124] (2 PDB entries)
    5. 2137195Species Plasmodium vivax [TaxId:5855] [187469] (4 PDB entries)
    6. 2137200Species Pneumocystis jirovecii [TaxId:42068] [197174] (1 PDB entry)
    7. 2137202Species Staphylococcus aureus [TaxId:1280] [195885] (5 PDB entries)
    8. 2137211Species Staphylococcus aureus [TaxId:273036] [274776] (1 PDB entry)
    9. 2271411Species Yersinia pestis [TaxId:214092] [314715] (1 PDB entry)
    10. 2284213Species Mycobacterium tuberculosis [TaxId:1773] [327514] (2 PDB entries)
    11. 2286058Species Mycobacterium tuberculosis [TaxId:83332] [329359] (1 PDB entry)

More info for Family c.71.1.1: Dihydrofolate reductases

Timeline for Family c.71.1.1: Dihydrofolate reductases: