SCOPe 2.01: Family c.69.1.1: Acetylcholinesterase-like

Lineage for Family c.69.1.1: Acetylcholinesterase-like

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.69: alpha/beta-Hydrolases [53473] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest

4. Superfamily c.69.1: alpha/beta-Hydrolases [53474] (42 families)
   many members have left-handed crossover connection between strand 8 and additional strand 9

5. Family c.69.1.1: Acetylcholinesterase-like [53475] (6 proteins)

Proteins:

1. Acetylcholinesterase [53476] (5 species)

   1. Species Electric eel (Electrophorus electricus) [TaxId:8005] [53478] (3 PDB entries)

   2. Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [53481] (3 PDB entries)

   3. Species Human (Homo sapiens) [TaxId:9606] [53480] (2 PDB entries)

   4. Species Mouse (Mus musculus) [TaxId:10090] [53479] (14 PDB entries)

   5. Species Pacific electric ray (Torpedo californica) [TaxId:7787] [53477] (76 PDB entries)
      Uniprot P04058 25-556

2. Bile-salt activated lipase (cholesterol esterase) [53482] (2 species)

   1. Species Cow (Bos taurus) [TaxId:9913] [53483] (3 PDB entries)

   2. Species Human (Homo sapiens) [TaxId:9606] [53484] (2 PDB entries)

3. Butyryl cholinesterase [102612] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [102613] (7 PDB entries)

4. Mammalian carboxylesterase (liver carboxylesterase I) [75282] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [89768] (9 PDB entries)

   2. Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [75283] (1 PDB entry)

5. Thermophilic para-nitrobenzyl esterase (PNB esterase) [53485] (1 species)

   • Species Bacillus subtilis [TaxId:1423] [53486] (3 PDB entries)

6. automated matches [190065] (3 species)
   not a true protein

   1. Species Human (Homo sapiens) [TaxId:9606] [186857] (24 PDB entries)

   2. Species Mouse (Mus musculus) [TaxId:10090] [187006] (39 PDB entries)

   3. Species Pacific electric ray (Torpedo californica) [TaxId:7787] [186783] (1 PDB entry)

More info for Family c.69.1.1: Acetylcholinesterase-like

Timeline for Family c.69.1.1: Acetylcholinesterase-like:

• Family c.69.1.1: Acetylcholinesterase-like first appeared (with stable ids) in SCOP 1.55
  
• Family c.69.1.1: Acetylcholinesterase-like appears in SCOP 1.75
  
• Family c.69.1.1: Acetylcholinesterase-like appears in SCOPe 2.02
  
• Family c.69.1.1: Acetylcholinesterase-like appears in the current release, SCOPe 2.08