SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family c.69.1.1: Acetylcholinesterase-like

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2134062Fold c.69: alpha/beta-Hydrolases [53473] (1 superfamily)
    core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest
  4. 2134063Superfamily c.69.1: alpha/beta-Hydrolases [53474] (42 families) (S)
    many members have left-handed crossover connection between strand 8 and additional strand 9
  5. 2134064Family c.69.1.1: Acetylcholinesterase-like [53475] (6 protein domains)
    automatically mapped to Pfam PF00135

Protein Domains:

  1. 2134065Acetylcholinesterase [53476] (5 species)
    1. 2134066Species Electric eel (Electrophorus electricus) [TaxId:8005] [53478] (3 PDB entries)
    2. 2134073Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [53481] (3 PDB entries)
    3. 2134077Species Human (Homo sapiens) [TaxId:9606] [53480] (11 PDB entries)
    4. 2134094Species Mouse (Mus musculus) [TaxId:10090] [53479] (28 PDB entries)
    5. 2134137Species Pacific electric ray (Torpedo californica) [TaxId:7787] [53477] (86 PDB entries)
      Uniprot P04058 25-556
  2. 2134231Bile-salt activated lipase (cholesterol esterase) [53482] (2 species)
    1. 2134232Species Cow (Bos taurus) [TaxId:9913] [53483] (3 PDB entries)
    2. 2134237Species Human (Homo sapiens) [TaxId:9606] [53484] (2 PDB entries)
  3. 2134240Butyryl cholinesterase [102612] (1 species)
  4. 2134248Mammalian carboxylesterase (liver carboxylesterase I) [75282] (2 species)
    1. 2134249Species Human (Homo sapiens) [TaxId:9606] [89768] (7 PDB entries)
    2. 2134293Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [75283] (1 PDB entry)
  5. 2134295Thermophilic para-nitrobenzyl esterase (PNB esterase) [53485] (1 species)
  6. 2134301automated matches [190065] (6 species)
    not a true protein
    1. 2134302Species Bacillus subtilis [311120] (1 PDB entry)
    2. 2134304Species Banded krait (Bungarus fasciatus) [TaxId:8613] [261265] (1 PDB entry)
    3. 2134307Species Human (Homo sapiens) [TaxId:9606] [186857] (44 PDB entries)
    4. 2134368Species Mouse (Mus musculus) [TaxId:10090] [187006] (55 PDB entries)
    5. 2134477Species Pacific electric ray (Torpedo californica) [TaxId:7787] [186783] (6 PDB entries)
    6. 2286403Species Sus scrofa [TaxId:9823] [329704] (1 PDB entry)

More info for Family c.69.1.1: Acetylcholinesterase-like

Timeline for Family c.69.1.1: Acetylcholinesterase-like: