Class c: Alpha and beta proteins (a/b) [51349] (147 folds) |
Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily) core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest |
Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (58 families) |
c.66.1.1: COMT-like [53336] (4 proteins) |
c.66.1.2: RNA methyltransferase FtsJ [53339] (1 protein) automatically mapped to Pfam PF01728 |
c.66.1.3: Fibrillarin homologue [53342] (1 protein) automatically mapped to Pfam PF01269 |
c.66.1.4: Hypothetical protein MJ0882 [53345] (1 protein) automatically mapped to Pfam PF05175 |
c.66.1.5: Glycine N-methyltransferase [53348] (1 protein) |
c.66.1.6: Arginine methyltransferase [53351] (3 proteins) lacks the last two strands of the common fold replaced with a beta-sandwich oligomerisation subdomain |
c.66.1.7: Protein-L-isoaspartyl O-methyltransferase [53354] (1 protein) topological variant; strand order 3214567; strand 6 is antiparallel to the rest automatically mapped to Pfam PF01135 |
c.66.1.8: Chemotaxis receptor methyltransferase CheR, C-terminal domain [53357] (1 protein) contains additional N-terminal all-alpha domain, res. 11-91 automatically mapped to Pfam PF01739 |
c.66.1.11: Type II DNA methylase [53377] (3 proteins) circularly permuted version of the common fold |
c.66.1.12: Plant O-methyltransferase, C-terminal domain [64111] (6 proteins) automatically mapped to Pfam PF00891 |
c.66.1.13: tRNA(1-methyladenosine) methyltransferase-like [64117] (5 proteins) contains additional N-terminal beta-sandwich domain |
c.66.1.14: Hypothetical protein HI0319 (YecO) [69544] (2 proteins) |
c.66.1.15: Arylamine N-methyltransferase [69547] (3 proteins) automatically mapped to Pfam PF01234 |
c.66.1.16: Guanidinoacetate methyltransferase [69550] (1 protein) |
c.66.1.17: Spermidine synthase [69557] (3 proteins) contains additional N-terminal tetramerisation all-beta domain, res. 1-71 |
c.66.1.18: Mycolic acid cyclopropane synthase [69560] (7 proteins) |
c.66.1.19: Histamine methyltransferase [75261] (1 protein) |
c.66.1.20: Glucose-inhibited division protein B (GidB) [75264] (1 protein) automatically mapped to Pfam PF02527 |
c.66.1.21: Hypothetical Protein YjhP [82469] (1 protein) |
c.66.1.22: Precorrin-6Y methyltransferase (CbiT) [82472] (1 protein) |
c.66.1.23: MraW-like putative methyltransferases [82475] (1 protein) |
c.66.1.24: rRNA adenine dimethylase-like [88784] (5 proteins) |
c.66.1.25: mRNA cap methylase [88785] (3 proteins) |
c.66.1.26: C5 cytosine-specific DNA methylase, DCM [88786] (4 proteins) automatically mapped to Pfam PF00145 |
c.66.1.27: DNA methylase TaqI, N-terminal domain [88787] (1 protein) |
c.66.1.28: N6 adenine-specific DNA methylase, DAM [88788] (3 proteins) automatically mapped to Pfam PF02086 |
c.66.1.29: rRNA methyltransferase AviRa [89738] (1 protein) automatically mapped to Pfam PF11599 |
c.66.1.30: N5-glutamine methyltransferase, HemK [89743] (2 proteins) |
c.66.1.31: Catalytic, N-terminal domain of histone methyltransferase Dot1l [89746] (2 proteins) |
c.66.1.32: Ta1320-like [89751] (2 proteins) |
c.66.1.33: rRNA methyltransferase RlmA [102557] (1 protein) |
c.66.1.34: mRNA cap (Guanine N-7) methyltransferase [102560] (1 protein) mRNA capping enzyme automatically mapped to Pfam PF03291 |
c.66.1.35: Salicylic acid carboxyl methyltransferase (SAMT) [102563] (1 protein) automatically mapped to Pfam PF03492 |
c.66.1.36: Thiopurine S-methyltransferase [102566] (1 protein) automatically mapped to Pfam PF05724 |
c.66.1.37: Leucine carboxy methyltransferase Ppm1 [102569] (1 protein) |
c.66.1.38: NOL1/NOP2/sun [102575] (3 proteins) Pfam PF01189; contains additional N-terminal 3-helical and ferredoxin-like domains |
c.66.1.39: Ribosomal protein L11 methyltransferase PrmA [102578] (1 protein) contains additional N-terminal ferredoxin-like domain automatically mapped to Pfam PF06325 |
c.66.1.40: (Uracil-5-)-methyltransferase [102581] (1 protein) Pfam PF05958 |
c.66.1.41: UbiE/COQ5-like [110671] (5 proteins) Pfam PF01209 |
c.66.1.42: AD-003 protein-like [117685] (3 proteins) Pfam PF05891; DUF858 |
c.66.1.43: CAC2371-like [117688] (3 proteins) similar overall fold to the Glycine N-methyltransferase (53348) and mRNA cap (Guanine N-7) methyltransferase (102560) families |
c.66.1.44: TehB-like [142603] (2 proteins) Pfam PF03848; overall structural similarity to Thiopurine S-methyltransferase (Pfam PF05724) |
c.66.1.45: N-6 DNA Methylase-like [142606] (3 proteins) Pfam PF02384; contains C-terminal extension to the canonical fold and extra N-terminal all-alpha domain similar to the insert domain of the DAM family (88788) |
c.66.1.46: YhhF-like [142611] (6 proteins) Pfam PF03602 |
c.66.1.47: Met-10+ protein-like [142622] (1 protein) Pfam PF02475; contains extra N-terminal alpha+beta domain: beta(2)-alpha-beta(2); mixed beta-sheet; order: 1234; cf (102740) |
c.66.1.48: Nsp15 N-terminal domain-like [142625] (1 protein) rudiment methyltransferase fold that probably has lost the enzymatic activity; contains extra N-terminal alpha+beta subdomain |
c.66.1.49: BC2162-like [142629] (2 proteins) contains extra helical regions inserted after strands 5 and 6 of the canonical fold |
c.66.1.50: CmcI-like [142632] (1 protein) Pfam PF04989; may have evolved different enzymatic activity |
c.66.1.51: hypothetical RNA methyltransferase [142635] (4 proteins) C-terminal part of Pfam PF03602; similar to (Uracil-5-)-methyltransferase (Pfam PF05958) |
c.66.1.52: RPA4359-like [142644] (1 protein) Pfam PF02636; DUF185 |
c.66.1.53: TrmB-like [142647] (1 protein) Pfam PF02390 |
c.66.1.54: Methyltransferase 10 domain [142651] (2 proteins) Pfam PF05971; DUF890 |
c.66.1.55: YhiQ-like [159686] (1 protein) Pfam PF04445; DUF548; contains extra N-terminal alpha+beta subdomain [beta-alpha-beta(4)] |
c.66.1.56: FkbM-like [159691] (1 protein) contains extra N-terminal alpha/beta and all-alpha subdomains |
c.66.1.57: ML2640-like [159694] (2 proteins) Pfam PF02409; O-methyltransferase N-terminus (DUF142); most similar structure to the Leucine carboxy methyltransferase Ppm1 family |
c.66.1.58: TRM1-like [159697] (1 protein) Pfam PF02005; contains extra C-terminal alpha+beta subdomain |
c.66.1.59: LPG1296-like [159700] (1 protein) Pfam PF04378; DUF519 |
c.66.1.0: automated matches [191451] (1 protein) not a true family |
Timeline for Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases: