Lineage for Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases

  1. Root: SCOP 1.71
  2. 570216Class c: Alpha and beta proteins (a/b) [51349] (134 folds)
  3. 588626Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
    core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest
  4. 588627Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (41 families) (S)

Families:

  1. 588628c.66.1.1: Catechol O-methyltransferase, COMT [53336] (1 protein)
  2. 588634c.66.1.2: RNA methyltransferase FtsJ [53339] (1 protein)
  3. 588639c.66.1.3: Fibrillarin homologue [53342] (1 protein)
  4. 588649c.66.1.4: Hypothetical protein MJ0882 [53345] (1 protein)
  5. 588653c.66.1.5: Glycine N-methyltransferase [53348] (1 protein)
  6. 588694c.66.1.6: Arginine methyltransferase [53351] (2 proteins)
    lacks the last two strands of the common fold replaced with a beta-sandwich oligomerisation subdomain
  7. 588710c.66.1.7: Protein-L-isoaspartyl O-methyltransferase [53354] (1 protein)
    topological variant; strand order 3214567; strand 6 is antiparallel to the rest
  8. 588731c.66.1.8: Chemotaxis receptor methyltransferase CheR, C-terminal domain [53357] (1 protein)
    contains additional N-terminal all-alpha domain, res. 11-91
  9. 588736c.66.1.11: Type II DNA methylase [53377] (3 proteins)
    circularly permuted version of the common fold
  10. 588751c.66.1.12: Plant O-methyltransferase, C-terminal domain [64111] (5 proteins)
  11. 588781c.66.1.13: tRNA(1-methyladenosine) methyltransferase-like [64117] (2 proteins)
    contains additional N-terminal beta-sandwich domain
  12. 588788c.66.1.14: Hypothetical protein HI0319 (YecO) [69544] (1 protein)
  13. 588793c.66.1.15: Phenylethanolamine N-methyltransferase, PNMTase [69547] (1 protein)
  14. 588802c.66.1.16: Guanidinoacetate methyltransferase [69550] (1 protein)
  15. 588815c.66.1.17: Spermidine synthase [69557] (2 proteins)
    contains additional N-terminal tetramerisation all-beta domain, res. 1-71
  16. 588843c.66.1.18: Mycolic acid cyclopropane synthase [69560] (4 proteins)
  17. 588866c.66.1.19: Histamine methyltransferase [75261] (1 protein)
  18. 588873c.66.1.20: Glucose-inhibited division protein B (GidB) [75264] (1 protein)
  19. 588879c.66.1.21: Hypothetical Protein YjhP [82469] (1 protein)
  20. 588885c.66.1.22: Precorrin-6Y methyltransferase (CbiT) [82472] (1 protein)
  21. 588918c.66.1.23: MraW-like putative methyltransferases [82475] (1 protein)
  22. 588928c.66.1.24: rRNA adenine dimethylase-like [88784] (3 proteins)
  23. 588946c.66.1.25: mRNA cap methylase [88785] (2 proteins)
  24. 588970c.66.1.26: C5 cytosine-specific DNA methylase, DCM [88786] (3 proteins)
  25. 588996c.66.1.27: DNA methylase TaqI, N-terminal domain [88787] (1 protein)
  26. 589007c.66.1.28: N6 adenine-specific DNA methylase, DAM [88788] (2 proteins)
  27. 589016c.66.1.29: rRNA methyltransferase AviRa [89738] (1 protein)
  28. 589021c.66.1.30: N5-glutamine methyltransferase, HemK [89743] (1 protein)
  29. 589032c.66.1.31: Catalytic, N-terminal domain of histone methyltransferase Dot1l [89746] (1 protein)
  30. 589040c.66.1.32: Hypothetical protein Ta1320 [89751] (1 protein)
  31. 589045c.66.1.33: rRNA methyltransferase RlmA [102557] (1 protein)
  32. 589050c.66.1.34: mRNA cap (Guanine N-7) methyltransferase [102560] (1 protein)
    mRNA capping enzyme
  33. 589058c.66.1.35: Salicylic acid carboxyl methyltransferase (SAMT) [102563] (1 protein)
  34. 589062c.66.1.36: Thiopurine S-methyltransferase [102566] (1 protein)
  35. 589066c.66.1.37: Leucine carboxy methyltransferase Ppm1 [102569] (1 protein)
  36. 589079c.66.1.38: NOL1/NOP2/sun [102575] (2 proteins)
    Pfam 01189; contains additional N-terminal 3-helical and ferredoxin-like domains
  37. 589087c.66.1.39: Ribosomal protein L11 methyltransferase PrmA [102578] (1 protein)
    contains additional N-terminal ferredoxin-like domain
  38. 589091c.66.1.40: (Uracil-5-)-methyltransferase [102581] (1 protein)
    Pfam 05958
  39. 589095c.66.1.41: UbiE/COQ5-like [110671] (3 proteins)
    Pfam 01209
  40. 589110c.66.1.42: AD-003 protein-like [117685] (1 protein)
    Pfam 05891; DUF858
  41. 589114c.66.1.43: CAC2371-like [117688] (1 protein)
    similar overall fold to the Glycine N-methyltransferase (scop_fa 53348) and mRNA cap (Guanine N-7) methyltransferase (scop_fa 102560) families

More info for Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases

Timeline for Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases: