Lineage for Family c.61.1.1: Phosphoribosyltransferases (PRTases)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2128255Fold c.61: PRTase-like [53270] (1 superfamily)
    core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 321456; strand 3 is antiparallel to the rest
  4. 2128256Superfamily c.61.1: PRTase-like [53271] (3 families) (S)
  5. 2128257Family c.61.1.1: Phosphoribosyltransferases (PRTases) [53272] (16 protein domains)

Protein Domains:

  1. 2128258Adenine PRTase [53288] (5 species)
    1. 2128259Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [69541] (2 PDB entries)
    2. 2128263Species Giardia intestinalis [TaxId:5741] [82455] (2 PDB entries)
    3. 2128266Species Human (Homo sapiens) [TaxId:9606] [102536] (6 PDB entries)
    4. 2128277Species Leishmania donovani [TaxId:5661] [53289] (4 PDB entries)
    5. 2128282Species Leishmania tarentolae [TaxId:5689] [102535] (1 PDB entry)
  2. 2128284Glutamine PRPP amidotransferase, C-terminal domain [53278] (2 species)
    1. 2128285Species Bacillus subtilis [TaxId:1423] [53279] (2 PDB entries)
    2. 2128294Species Escherichia coli [TaxId:562] [53280] (5 PDB entries)
  3. 2128309Guanine PRTase [53281] (1 species)
  4. 2128315Hypoxanthine PRTase [53286] (4 species)
    1. 2128316Species Escherichia coli [TaxId:562] [75255] (3 PDB entries)
    2. 2128323Species Salmonella typhimurium [TaxId:90371] [89728] (1 PDB entry)
    3. 2128326Species Trypanosoma cruzi [TaxId:5693] [53287] (9 PDB entries)
      Uniprot Q27796
    4. 2281625Species Trypanosoma brucei [TaxId:5702] [324926] (5 PDB entries)
  5. 2128349Hypoxanthine-guanine PRTase (HGPRTase) [53283] (3 species)
    1. 2128350Species Human (Homo sapiens) [TaxId:9606] [53284] (19 PDB entries)
    2. 2128410Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [53285] (1 PDB entry)
    3. 2128415Species Thermoanaerobacter tengcongensis [TaxId:119072] [117671] (1 PDB entry)
      Uniprot Q8R7L0
  6. 2128418Hypoxanthine-guanine-xanthine PRTase [53275] (3 species)
    1. 2128419Species Leishmania tarentolae [TaxId:5689] [110658] (1 PDB entry)
      Uniprot Q9NJI5
    2. 2128422Species Toxoplasma gondii [TaxId:5811] [53277] (5 PDB entries)
    3. 2128439Species Tritrichomonas foetus [TaxId:5724] [53276] (1 PDB entry)
  7. 2128442Orotate PRTase [53290] (3 species)
    1. 2128443Species Escherichia coli [TaxId:562] [53292] (1 PDB entry)
    2. 2128446Species Salmonella typhimurium [TaxId:90371] [53291] (3 PDB entries)
    3. 2128451Species Streptococcus pyogenes [TaxId:1314] [142553] (1 PDB entry)
      Uniprot Q9A076 1-208
  8. 2128454Pprobable purine phosphoribosyltransferase PH0095 [142560] (1 species)
  9. 2128468Pur operon repressor (PurR), C-terminal domain [102539] (1 species)
  10. 2128482Putative phosphoribosyltransferase TT1426 (TTHA1462) [117673] (1 species)
  11. 2128485Putative phosphoribosyltransferase TTHA1613 [142558] (1 species)
    putative APRTase in UniProt
  12. 2128488Pyrimidine operon regulator PyrR [109612] (4 species)
    bifunctional protein; contains the uracil PRTase and Pyr RNA-binding activities
    1. 2128489Species Bacillus caldolyticus [TaxId:1394] [110659] (4 PDB entries)
      Uniprot P41007
    2. 2128500Species Bacillus subtilis [TaxId:1423] [53294] (2 PDB entries)
    3. 2128504Species Mycobacterium tuberculosis [TaxId:1773] [117672] (1 PDB entry)
      Uniprot P71807
    4. 2128507Species Thermus thermophilus [TaxId:274] [102537] (1 PDB entry)
      TT1027
  13. 2128512Uracil PRTase, Upp [53293] (5 species)
    1. 2128513Species Bacillus caldolyticus [TaxId:1394] [75256] (1 PDB entry)
    2. 2128516Species Sulfolobus solfataricus [TaxId:2287] [142555] (5 PDB entries)
      Uniprot Q980Q4 2-216
    3. 2128542Species Thermotoga maritima [TaxId:2336] [102538] (1 PDB entry)
      TM0721
    4. 2128547Species Thermus thermophilus [TaxId:274] [142554] (1 PDB entry)
      Uniprot Q72J35 1-208
    5. 2128549Species Toxoplasma gondii [TaxId:5811] [53295] (6 PDB entries)
  14. 2128574Xanthine phosphoribosyltransferase [142556] (1 species)
  15. 2128582Xanthine-guanine PRTase (XPRTase) [53273] (2 species)
    1. 2128583Species Escherichia coli [TaxId:562] [53274] (7 PDB entries)
    2. 2128612Species Thermoanaerobacter tengcongensis [TaxId:119072] [142552] (1 PDB entry)
      Uniprot Q8R7L0 3-180
  16. 2128615automated matches [190074] (13 species)
    not a true protein
    1. 2128616Species Bacillus subtilis [TaxId:1423] [261868] (1 PDB entry)
    2. 2128621Species Bacillus subtilis [TaxId:224308] [261871] (1 PDB entry)
    3. 2128623Species Burkholderia pseudomallei [TaxId:28450] [188498] (1 PDB entry)
    4. 2128628Species Human (Homo sapiens) [TaxId:9606] [187905] (1 PDB entry)
    5. 2128631Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [188472] (1 PDB entry)
    6. 2128634Species Thermoanaerobacter tengcongensis [TaxId:119072] [187747] (1 PDB entry)
    7. 2128636Species Thermus thermophilus HB8 [TaxId:300852] [186795] (1 PDB entry)
    8. 2128640Species Thermus thermophilus [TaxId:274] [188051] (1 PDB entry)
    9. 2128645Species Vibrio cholerae [TaxId:666] [189453] (1 PDB entry)
    10. 2270766Species Trypanosoma cruzi [TaxId:353153] [314071] (1 PDB entry)
    11. 2271747Species Mycobacterium tuberculosis [TaxId:419947] [315048] (1 PDB entry)
    12. 2285183Species Plasmodium vivax [TaxId:5855] [328484] (1 PDB entry)
    13. 2293499Species Escherichia coli [TaxId:562] [336800] (6 PDB entries)

More info for Family c.61.1.1: Phosphoribosyltransferases (PRTases)

Timeline for Family c.61.1.1: Phosphoribosyltransferases (PRTases):