SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family c.61.1.1: Phosphoribosyltransferases (PRTases)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2128255Fold c.61: PRTase-like [53270] (1 superfamily)
    core: 3 layers, a/b/a; mixed beta-sheet of 6 strands, order 321456; strand 3 is antiparallel to the rest
  4. 2128256Superfamily c.61.1: PRTase-like [53271] (3 families) (S)
  5. 2128257Family c.61.1.1: Phosphoribosyltransferases (PRTases) [53272] (16 protein domains)

Protein Domains:

  1. 2128258Adenine PRTase [53288] (5 species)
    1. 2128259Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [69541] (2 PDB entries)
    2. 2128263Species Giardia intestinalis [TaxId:5741] [82455] (2 PDB entries)
    3. 2128266Species Human (Homo sapiens) [TaxId:9606] [102536] (6 PDB entries)
    4. 2128277Species Leishmania donovani [TaxId:5661] [53289] (4 PDB entries)
    5. 2128282Species Leishmania tarentolae [TaxId:5689] [102535] (1 PDB entry)
  2. 2128284Glutamine PRPP amidotransferase, C-terminal domain [53278] (2 species)
    1. 2128285Species Bacillus subtilis [TaxId:1423] [53279] (2 PDB entries)
    2. 2128294Species Escherichia coli [TaxId:562] [53280] (5 PDB entries)
  3. 2128309Guanine PRTase [53281] (1 species)
  4. 2128315Hypoxanthine PRTase [53286] (4 species)
    1. 2128316Species Escherichia coli [TaxId:562] [75255] (3 PDB entries)
    2. 2128323Species Salmonella typhimurium [TaxId:90371] [89728] (1 PDB entry)
    3. 2128326Species Trypanosoma cruzi [TaxId:5693] [53287] (9 PDB entries)
      Uniprot Q27796
    4. 2281625Species Trypanosoma brucei [TaxId:5702] [324926] (5 PDB entries)
  5. 2128349Hypoxanthine-guanine PRTase (HGPRTase) [53283] (3 species)
    1. 2128350Species Human (Homo sapiens) [TaxId:9606] [53284] (18 PDB entries)
    2. 2128410Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [53285] (1 PDB entry)
    3. 2128415Species Thermoanaerobacter tengcongensis [TaxId:119072] [117671] (1 PDB entry)
      Uniprot Q8R7L0
  6. 2128418Hypoxanthine-guanine-xanthine PRTase [53275] (3 species)
    1. 2128419Species Leishmania tarentolae [TaxId:5689] [110658] (1 PDB entry)
      Uniprot Q9NJI5
    2. 2128422Species Toxoplasma gondii [TaxId:5811] [53277] (5 PDB entries)
    3. 2128439Species Tritrichomonas foetus [TaxId:5724] [53276] (1 PDB entry)
  7. 2128442Orotate PRTase [53290] (3 species)
    1. 2128443Species Escherichia coli [TaxId:562] [53292] (1 PDB entry)
    2. 2128446Species Salmonella typhimurium [TaxId:90371] [53291] (3 PDB entries)
    3. 2128451Species Streptococcus pyogenes [TaxId:1314] [142553] (1 PDB entry)
      Uniprot Q9A076 1-208
  8. 2128454Pprobable purine phosphoribosyltransferase PH0095 [142560] (1 species)
  9. 2128468Pur operon repressor (PurR), C-terminal domain [102539] (1 species)
  10. 2128482Putative phosphoribosyltransferase TT1426 (TTHA1462) [117673] (1 species)
  11. 2128485Putative phosphoribosyltransferase TTHA1613 [142558] (1 species)
    putative APRTase in UniProt
  12. 2128488Pyrimidine operon regulator PyrR [109612] (4 species)
    bifunctional protein; contains the uracil PRTase and Pyr RNA-binding activities
    1. 2128489Species Bacillus caldolyticus [TaxId:1394] [110659] (4 PDB entries)
      Uniprot P41007
    2. 2128500Species Bacillus subtilis [TaxId:1423] [53294] (2 PDB entries)
    3. 2128504Species Mycobacterium tuberculosis [TaxId:1773] [117672] (1 PDB entry)
      Uniprot P71807
    4. 2128507Species Thermus thermophilus [TaxId:274] [102537] (1 PDB entry)
      TT1027
  13. 2128512Uracil PRTase, Upp [53293] (5 species)
    1. 2128513Species Bacillus caldolyticus [TaxId:1394] [75256] (1 PDB entry)
    2. 2128516Species Sulfolobus solfataricus [TaxId:2287] [142555] (5 PDB entries)
      Uniprot Q980Q4 2-216
    3. 2128542Species Thermotoga maritima [TaxId:2336] [102538] (1 PDB entry)
      TM0721
    4. 2128547Species Thermus thermophilus [TaxId:274] [142554] (1 PDB entry)
      Uniprot Q72J35 1-208
    5. 2128549Species Toxoplasma gondii [TaxId:5811] [53295] (6 PDB entries)
  14. 2128574Xanthine phosphoribosyltransferase [142556] (1 species)
  15. 2128582Xanthine-guanine PRTase (XPRTase) [53273] (2 species)
    1. 2128583Species Escherichia coli [TaxId:562] [53274] (7 PDB entries)
    2. 2128612Species Thermoanaerobacter tengcongensis [TaxId:119072] [142552] (1 PDB entry)
      Uniprot Q8R7L0 3-180
  16. 2128615automated matches [190074] (12 species)
    not a true protein
    1. 2128616Species Bacillus subtilis [TaxId:1423] [261868] (1 PDB entry)
    2. 2128621Species Bacillus subtilis [TaxId:224308] [261871] (1 PDB entry)
    3. 2128623Species Burkholderia pseudomallei [TaxId:28450] [188498] (1 PDB entry)
    4. 2128628Species Human (Homo sapiens) [TaxId:9606] [187905] (1 PDB entry)
    5. 2128631Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [188472] (1 PDB entry)
    6. 2128634Species Thermoanaerobacter tengcongensis [TaxId:119072] [187747] (1 PDB entry)
    7. 2128636Species Thermus thermophilus HB8 [TaxId:300852] [186795] (1 PDB entry)
    8. 2128640Species Thermus thermophilus [TaxId:274] [188051] (1 PDB entry)
    9. 2128645Species Vibrio cholerae [TaxId:666] [189453] (1 PDB entry)
    10. 2270766Species Trypanosoma cruzi [TaxId:353153] [314071] (1 PDB entry)
    11. 2271747Species Mycobacterium tuberculosis [TaxId:419947] [315048] (1 PDB entry)
    12. 2285183Species Plasmodium vivax [TaxId:5855] [328484] (1 PDB entry)

More info for Family c.61.1.1: Phosphoribosyltransferases (PRTases)

Timeline for Family c.61.1.1: Phosphoribosyltransferases (PRTases):