SCOPe 2.08: Protein: Tetrahydrofolate dehydrogenase/cyclohydrolase

Lineage for Protein: Tetrahydrofolate dehydrogenase/cyclohydrolase

Root: SCOPe 2.08
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
Fold c.58: Aminoacid dehydrogenase-like, N-terminal domain [53222] (1 superfamily)
core: 3 layers: a/b/a; parallel beta-sheet of 4 strands; 2134
Superfamily c.58.1: Aminoacid dehydrogenase-like, N-terminal domain [53223] (6 families)
Family c.58.1.2: Tetrahydrofolate dehydrogenase/cyclohydrolase [53235] (2 proteins)
automatically mapped to Pfam PF00763
Protein Tetrahydrofolate dehydrogenase/cyclohydrolase [53236] (3 species)
the two-domain organization is similar to that of aminoacid dehydrogenases, but both domains are truncated

Species:

Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [53239] (2 PDB entries)
1. Domain for 1edz:
  - Domain d1edza2: 1edz A:3-148 [33935]
    Other proteins in same PDB: d1edza1
2. Domain for 1ee9:
  - Domain d1ee9a2: 1ee9 A:3-148 [33936]
    Other proteins in same PDB: d1ee9a1
    complexed with nad
Escherichia coli [TaxId:562] [53238] (1 PDB entry)
- Domain for 1b0a:
  - Domain d1b0aa2: 1b0a A:2-122 [33934]
    Other proteins in same PDB: d1b0aa1
Human (Homo sapiens) [TaxId:9606] [53237] (7 PDB entries)
1. Domains for 1a4i:
  1. Domain d1a4ia2: 1a4i A:2-126 [33926]
    Other proteins in same PDB: d1a4ia1, d1a4ib1
    complexed with ndp
  2. Domain d1a4ib2: 1a4i B:2-126 [33927]
    Other proteins in same PDB: d1a4ia1, d1a4ib1
    complexed with ndp
2. Domains for 1dia:
  1. Domain d1diaa2: 1dia A:2-126 [33928]
    Other proteins in same PDB: d1diaa1, d1diab1
    complexed with l24, nap
  2. Domain d1diab2: 1dia B:1002-1126 [33929]
    Other proteins in same PDB: d1diaa1, d1diab1
    complexed with l24, nap
3. Domains for 1dib:
  1. Domain d1diba2: 1dib A:2-126 [33932]
    Other proteins in same PDB: d1diba1, d1dibb1
    complexed with l34, nap
  2. Domain d1dibb2: 1dib B:1002-1126 [33933]
    Other proteins in same PDB: d1diba1, d1dibb1
    complexed with l34, nap
4. Domains for 1dig:
  1. Domain d1diga2: 1dig A:2-126 [33930]
    Other proteins in same PDB: d1diga1, d1digb1
    complexed with act, l37, nap
  2. Domain d1digb2: 1dig B:1002-1126 [33931]
    Other proteins in same PDB: d1diga1, d1digb1
    complexed with act, l37, nap
5. Domains for 6ecp:
  1. Domain d6ecpa1: 6ecp A:2-126 [366814]
    Other proteins in same PDB: d6ecpa2, d6ecpb2
    automated match to d1diga2
    complexed with 21v, nap
  2. Domain d6ecpb1: 6ecp B:2-126 [366761]
    Other proteins in same PDB: d6ecpa2, d6ecpb2
    automated match to d1diga2
    complexed with 21v, nap
6. Domains for 6ecq:
  1. Domain d6ecqa1: 6ecq A:2-126 [366742]
    Other proteins in same PDB: d6ecqa2, d6ecqb2
    automated match to d1a4ia2
    complexed with lud, nap
  2. Domain d6ecqb1: 6ecq B:2-126 [366770]
    Other proteins in same PDB: d6ecqa2, d6ecqb2
    automated match to d1a4ia2
    complexed with lud, nap
7. Domains for 6ecr:
  1. Domain d6ecra1: 6ecr A:2-126 [366804]
    Other proteins in same PDB: d6ecra2, d6ecrb2
    automated match to d1a4ia2
    complexed with act, nap
  2. Domain d6ecrb1: 6ecr B:2-126 [366747]
    Other proteins in same PDB: d6ecra2, d6ecrb2
    automated match to d1a4ia2
    complexed with act, nap

More info for Protein Tetrahydrofolate dehydrogenase/cyclohydrolase from c.58.1.2: Tetrahydrofolate dehydrogenase/cyclohydrolase

Timeline for Protein Tetrahydrofolate dehydrogenase/cyclohydrolase from c.58.1.2: Tetrahydrofolate dehydrogenase/cyclohydrolase:

Protein Tetrahydrofolate dehydrogenase/cyclohydrolase from c.58.1.2: Tetrahydrofolate dehydrogenase/cyclohydrolase first appeared (with stable ids) in SCOP 1.55
Protein Tetrahydrofolate dehydrogenase/cyclohydrolase from c.58.1.2: Tetrahydrofolate dehydrogenase/cyclohydrolase appears in SCOPe 2.07