SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family c.56.2.1: Purine and uridine phosphorylases

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2125386Fold c.56: Phosphorylase/hydrolase-like [53162] (8 superfamilies)
    core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops
  4. 2125403Superfamily c.56.2: Purine and uridine phosphorylases [53167] (2 families) (S)
    complex architecture; contains mixed beta-sheet of 8 strands, order 23415867, strands 3, 6 & 7 are antiparallel to the rest; and barrel, closed; n=5, S=8
  5. 2125404Family c.56.2.1: Purine and uridine phosphorylases [53168] (7 protein domains)

Protein Domains:

  1. 21254055'-deoxy-5'-methylthioadenosine phosphorylase [53174] (3 species)
    1. 2125406Species Human (Homo sapiens) [TaxId:9606] [53175] (9 PDB entries)
      Uniprot Q13126
    2. 2125421Species Sulfolobus solfataricus [TaxId:2287] [69536] (9 PDB entries)
    3. 2125458Species Sulfolobus tokodaii [TaxId:111955] [117657] (1 PDB entry)
      Uniprot Q975C3
  2. 21254625'-Methylthioadenosine/S-Adenosylhomocysteine nucleosidase [82448] (3 species)
    1. 2125463Species Escherichia coli [TaxId:562] [82449] (8 PDB entries)
    2. 2125479Species Neisseria meningitidis [TaxId:491] [188964] (1 PDB entry)
    3. 2125482Species Staphylococcus aureus [TaxId:1280] [188463] (1 PDB entry)
  3. 2125484AMP nucleosidase [110645] (2 species)
    contains extra N-terminal oligomerisation (sub)domain (8-153)
    1. 2125485Species Bacteroides thetaiotaomicron [TaxId:818] [117658] (1 PDB entry)
      Uniprot Q7MVU1
    2. 2125489Species Escherichia coli [TaxId:562] [110646] (4 PDB entries)
      Uniprot P15272
  4. 2125514Purine nucleoside phosphorylase, PNP [53169] (13 species)
    1. 2125515Species Anthrax bacillus (Bacillus anthracis) [TaxId:1392] [117655] (1 PDB entry)
      Uniprot Q81T09
    2. 2125522Species Bacillus cereus [TaxId:1396] [195935] (5 PDB entries)
    3. 2125528Species Bacillus cereus [TaxId:269801] [186942] (1 PDB entry)
    4. 2125531Species Cellulomonas sp. [TaxId:40001] [53173] (2 PDB entries)
    5. 2125538Species Cow (Bos taurus) [TaxId:9913] [53171] (20 PDB entries)
      Uniprot P55859
    6. 2125571Species Escherichia coli [TaxId:562] [53172] (27 PDB entries)
    7. 2125692Species Human (Homo sapiens) [TaxId:9606] [53170] (29 PDB entries)
      Uniprot P00491
    8. 2125731Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [226822] (1 PDB entry)
    9. 2125738Species Mycobacterium tuberculosis [TaxId:1773] [64098] (3 PDB entries)
    10. 2125748Species Thermotoga maritima [TaxId:2336] [117654] (1 PDB entry)
      Uniprot Q9X1T2
    11. 2125752Species Thermus thermophilus [TaxId:274] [89721] (4 PDB entries)
    12. 2125777Species Vibrio cholerae [TaxId:666] [102499] (2 PDB entries)
    13. 2286683Species Escherichia coli [TaxId:331111] [329984] (1 PDB entry)
  5. 2125790Putative uridine phosphorylase [102500] (1 species)
  6. 2125805Uridine phosphorylase [53176] (6 species)
    1. 2125806Species Escherichia coli [TaxId:562] [53177] (16 PDB entries)
    2. 2125909Species Salmonella enterica [TaxId:54388] [311321] (1 PDB entry)
    3. 2125919Species Salmonella typhimurium [TaxId:90371] [117656] (24 PDB entries)
      Uniprot P0A1F6
    4. 2126047Species Vibrio cholerae [TaxId:243277] [224899] (11 PDB entries)
    5. 2126096Species Yersinia pestis [TaxId:632] [238361] (1 PDB entry)
    6. 2126103Species Yersinia pseudotuberculosis [TaxId:633] [229814] (2 PDB entries)
  7. 2126112automated matches [190142] (19 species)
    not a true protein
    1. 2126113Species Aeropyrum pernix [TaxId:272557] [188092] (1 PDB entry)
    2. 2126115Species Bacillus subtilis [TaxId:1423] [193503] (14 PDB entries)
    3. 2126140Species Cow (Bos taurus) [TaxId:9913] [187265] (1 PDB entry)
    4. 2126142Species Escherichia coli [TaxId:562] [186867] (5 PDB entries)
    5. 2126162Species Human (Homo sapiens) [TaxId:9606] [256021] (6 PDB entries)
    6. 2126187Species Klebsiella pneumoniae [TaxId:272620] [193517] (1 PDB entry)
    7. 2126190Species Malaria parasite (Plasmodium knowlesi) [TaxId:5850] [225033] (1 PDB entry)
    8. 2126192Species Mycobacterium tuberculosis [TaxId:1773] [189596] (2 PDB entries)
    9. 2126197Species Plasmodium falciparum [TaxId:36329] [186993] (3 PDB entries)
    10. 2126207Species Plasmodium vivax [TaxId:5855] [188970] (1 PDB entry)
    11. 2126209Species Salmonella enterica [TaxId:904139] [196952] (5 PDB entries)
    12. 2126220Species Salmonella typhimurium [TaxId:99287] [187772] (1 PDB entry)
    13. 2126224Species Sulfolobus solfataricus [TaxId:2287] [187383] (2 PDB entries)
    14. 2126243Species Trichomonas vaginalis [TaxId:5722] [187838] (9 PDB entries)
    15. 2126260Species Vibrio cholerae [TaxId:243277] [189490] (2 PDB entries)
    16. 2126275Species Vibrio cholerae [TaxId:666] [188799] (2 PDB entries)
    17. 2126290Species Yersinia pseudotuberculosis [TaxId:273123] [268417] (1 PDB entry)
    18. 2126293Species Yersinia pseudotuberculosis [TaxId:502800] [189524] (1 PDB entry)
    19. 2285470Species Vibrio fischeri [TaxId:312309] [328771] (1 PDB entry)

More info for Family c.56.2.1: Purine and uridine phosphorylases

Timeline for Family c.56.2.1: Purine and uridine phosphorylases: