SCOP 1.75: Family c.55.3.1: Ribonuclease H

Lineage for Family c.55.3.1: Ribonuclease H

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.55: Ribonuclease H-like motif [53066] (7 superfamilies)
   3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145; strand 2 is antiparallel to the rest

4. Superfamily c.55.3: Ribonuclease H-like [53098] (14 families)
   consists of one domain of this fold

5. Family c.55.3.1: Ribonuclease H [53099] (4 proteins)

Proteins:

1. BH0863-like Ribonuclease H [142490] (1 species)
   new class of RNase H

   • Species Bacillus halodurans [TaxId:86665] [142491] (12 PDB entries)
     Uniprot Q9KEI9 61-193! Uniprot Q9KEI9 62-193
     BH0863

2. Class II ribonuclease H (RNase HII) [53103] (5 species)

   1. Species Archaeon Archaeoglobus fulgidus [TaxId:2234] [64093] (2 PDB entries)

   2. Species Archaeon Methanococcus jannaschii [TaxId:2190] [53104] (1 PDB entry)

   3. Species Archaeon Pyrococcus horikoshii [TaxId:53953] [110639] (2 PDB entries)
      Uniprot O59351

   4. Species Archaeon Thermococcus kodakaraensis [TaxId:311400] [64094] (2 PDB entries)

   5. Species Thermotoga maritima [TaxId:2336] [142489] (1 PDB entry)
      Uniprot Q9X017 1-221

3. HIV RNase H (Domain of reverse transcriptase) [53105] (2 species)

   1. Species Human immunodeficiency virus type 1 [TaxId:11676] [53106] (85 PDB entries)
      Uniprot P04585 159-692 # chain A coverage; chain B is shorter: 162-582
      Uniprot P03366 186-725 # chain A coverage; chain B coverage: 156-584
      Uniprot P04585 158-698 # chain A coverage; chain B is shorter: 159-595
      Uniprot P04585 159-692 # chain A coverage; chain B is shorter: 162-582 ! Uniprot P03366 186-725 # chain A coverage; chain B coverage: 156-584 ! Uniprot P04585 158-698 # chain A coverage; chain B is shorter: 159-595

   2. Species Human immunodeficiency virus type 2 [TaxId:11709] [82443] (1 PDB entry)

4. RNase H (RNase HI) [53100] (3 species)

   1. Species Escherichia coli [TaxId:562] [53101] (30 PDB entries)
      Uniprot P0A7Y4

   2. Species synthetic, Escherichia coli/Thermus thermophilus chimera [69532] (1 PDB entry)

   3. Species Thermus thermophilus [TaxId:274] [53102] (1 PDB entry)

More info for Family c.55.3.1: Ribonuclease H

Timeline for Family c.55.3.1: Ribonuclease H:

• Family c.55.3.1: Ribonuclease H first appeared (with stable ids) in SCOP 1.55
  
• Family c.55.3.1: Ribonuclease H appears in SCOP 1.73
  
• Family c.55.3.1: Ribonuclease H appears in SCOPe 2.01
  
• Family c.55.3.1: Ribonuclease H appears in the current release, SCOPe 2.08