SCOPe 2.05: Family c.120.1.2: 5' to 3' exonuclease catalytic domain

Lineage for Family c.120.1.2: 5' to 3' exonuclease catalytic domain

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.120: PIN domain-like [88722] (1 superfamily)
   3 layers, a/b/a; core: parallel beta-sheet of 5 strands, order 32145

4. Superfamily c.120.1: PIN domain-like [88723] (3 families)

5. Family c.120.1.2: 5' to 3' exonuclease catalytic domain [53045] (4 proteins)
   contains an alpha-helical arch and additional strand 6 antiparallel to the rest; strand order 321456; similarity to the resolvase-like fold

Proteins:

1. 5' to 3' exonuclease domain of DNA polymerase Taq [53048] (1 species)

   • Species Thermus aquaticus [TaxId:271] [53049] (3 PDB entries)

2. Flap endonuclease-1 (Fen-1 nuclease) [53052] (5 species)

   1. Species Archaeoglobus fulgidus [TaxId:2234] [102272] (2 PDB entries)

   2. Species Human (Homo sapiens) [TaxId:9606] [142118] (1 PDB entry)
      Uniprot P39748 2-217

   3. Species Methanococcus jannaschii [TaxId:2190] [53053] (2 PDB entries)

   4. Species Pyrococcus furiosus [TaxId:2261] [53055] (1 PDB entry)

   5. Species Pyrococcus horikoshii [TaxId:53953] [82436] (1 PDB entry)

3. T4 RNase H [53046] (1 species)

   • Species Bacteriophage T4 [TaxId:10665] [53047] (6 PDB entries)

4. T5 5'-exonuclease [53050] (1 species)

   • Species Bacteriophage T5 [TaxId:10726] [53051] (4 PDB entries)

More info for Family c.120.1.2: 5' to 3' exonuclease catalytic domain

Timeline for Family c.120.1.2: 5' to 3' exonuclease catalytic domain:

• Family c.120.1.2: 5' to 3' exonuclease catalytic domain first appeared (with stable ids) in SCOP 1.55, called Family c.53.1.2: 5' to 3' exonuclease
  
• Family c.120.1.2: 5' to 3' exonuclease catalytic domain appears in SCOPe 2.04
  
• Family c.120.1.2: 5' to 3' exonuclease catalytic domain appears in SCOPe 2.06
  
• Family c.120.1.2: 5' to 3' exonuclease catalytic domain appears in the current release, SCOPe 2.08