SCOP 1.75: Family c.47.1.5: Glutathione S-transferase (GST), N-terminal domain

Lineage for Family c.47.1.5: Glutathione S-transferase (GST), N-terminal domain

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.47: Thioredoxin fold [52832] (2 superfamilies)
   core: 3 layers, a/b/a; mixed beta-sheet of 4 strands, order 4312; strand 3 is antiparallel to the rest

4. Superfamily c.47.1: Thioredoxin-like [52833] (23 families)

5. Family c.47.1.5: Glutathione S-transferase (GST), N-terminal domain [52862] (18 proteins)

Proteins:

1. Chloride intracellular channel 1 (clic1) [69514] (1 species)
   similar to class theta enzymes; the N-domain undergoes a redox-controlled structural transition

   • Species Human (Homo sapiens) [TaxId:9606] [69515] (4 PDB entries)

2. Class alpha GST [81360] (8 species)

   1. Species Blood fluke (Schistosoma haematobium) [TaxId:6185] [89704] (8 PDB entries)

   2. Species Fasciola hepatica [TaxId:6192] [52879] (2 PDB entries)

   3. Species Human (Homo sapiens), (a1-1) [TaxId:9606] [52870] (19 PDB entries)
      Uniprot P08263

   4. Species Mouse (Mus musculus), (a1-1) [TaxId:10090] [52872] (2 PDB entries)

   5. Species Mouse (Mus musculus), (a1-4) [TaxId:10090] [52873] (2 PDB entries)

   6. Species Mouse (Mus musculus), (a2-2) [TaxId:10090] [89703] (1 PDB entry)

   7. Species Rat (Rattus norvegicus), (a1-1) [TaxId:10116] [52871] (2 PDB entries)

   8. Species Schistosoma japonicum [TaxId:6182] [52878] (12 PDB entries)
      Uniprot P08515

3. Class beta GST [81368] (3 species)

   1. Species Escherichia coli [TaxId:562] [52883] (3 PDB entries)

   2. Species Proteus mirabilis [TaxId:584] [52884] (2 PDB entries)

   3. Species Sphingomonas paucimobilis [TaxId:13689] [52885] (1 PDB entry)

4. Class delta GST [81366] (5 species)
   formerly a part of class theta enzymes

   1. Species African malaria mosquito (Anopheles gambiae), isozyme 1-6 [TaxId:7165] [102441] (1 PDB entry)

   2. Species Mosquito (Anopheles dirus b), isozyme 1-3 [TaxId:123217] [75234] (1 PDB entry)

   3. Species Mosquito (Anopheles dirus b), isozyme 1-4 [TaxId:123217] [75235] (1 PDB entry)

   4. Species Mosquito (Anopheles dirus b), isozyme 1-5 [TaxId:123217] [102439] (1 PDB entry)

   5. Species Mosquito (Anopheles dirus b), isozyme 1-6 [TaxId:123217] [102440] (1 PDB entry)

5. Class mu GST [81359] (3 species)

   1. Species Chicken (Gallus gallus) [TaxId:9031] [52869] (2 PDB entries)

   2. Species Human (Homo sapiens) [TaxId:9606] [52867] (15 PDB entries)
      Uniprot P09488
      Uniprot P28161
      Uniprot P09488 ! Uniprot P28161

   3. Species Rat (Rattus norvegicus) [TaxId:10116] [52868] (16 PDB entries)

6. Class omega GST [81363] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [52877] (1 PDB entry)

7. Class phi GST [81367] (3 species)

   1. Species Maize (Zea mays), type I [TaxId:4577] [52881] (2 PDB entries)

   2. Species Maize (Zea mays), type III [TaxId:4577] [52882] (1 PDB entry)

   3. Species Mouse-ear cress (Arabidopsis thaliana) [TaxId:3702] [52880] (2 PDB entries)

8. Class pi GST [81358] (4 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [52864] (41 PDB entries)

   2. Species Mouse (Mus musculus) [TaxId:10090] [52866] (9 PDB entries)

   3. Species Onchocerca volvulus [TaxId:6282] [117595] (2 PDB entries)
      Uniprot P46427

   4. Species Pig (Sus scrofa) [TaxId:9823] [52865] (1 PDB entry)

9. Class sigma GST [81362] (5 species)

   1. Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [82427] (1 PDB entry)

   2. Species Heligmosomoides polygyrus [TaxId:6339] [110608] (1 PDB entry)
      Uniprot Q9NJQ6 # Fragment

   3. Species Human (Homo sapiens) [TaxId:9606] [89705] (11 PDB entries)
      Uniprot O60760
      synonym: hematopoietic prostaglandin D synthase

   4. Species Rat (Rattus norvegicus) [TaxId:10116] [52875] (1 PDB entry)
      synonym: hematopoietic prostaglandin D synthase

   5. Species Squid (Ommastrephes sloani pacificus) [TaxId:6634] [52876] (2 PDB entries)

10. Class tau GST [81365] (2 species)

    1. Species Aegilops tauschii, also known as Triticum tauschii [TaxId:37682] [75236] (1 PDB entry)

    2. Species Rice (Oryza sativa) [TaxId:4530] [89706] (1 PDB entry)

11. Class theta GST [81361] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [52874] (3 PDB entries)

12. Class zeta GST [81364] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [64058] (1 PDB entry)
       maleylacetoacetate isomerase

    2. Species Mouse-ear cress (Arabidopsis thaliana) [TaxId:3702] [64059] (1 PDB entry)

13. Glutaredoxin 2 [64060] (1 species)
    similar to class zeta enzymes

    • Species Escherichia coli [TaxId:562] [64061] (1 PDB entry)

14. GST-like domain of elongation factor 1-gamma [82428] (1 species)

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [82429] (1 PDB entry)

15. Hypothetical protein AGR_pAT_752p/Atu5508 [142361] (1 species)
    putative glutathione S-transferase

    • Species Agrobacterium tumefaciens [TaxId:358] [142362] (1 PDB entry)
      Uniprot Q7D2W7 1-87

16. Microsomal prostaglandin E synthase-2 [142363] (1 species)

    • Species Crab-eating macaque (Macaca fascicularis) [TaxId:9541] [142364] (2 PDB entries)
      Uniprot Q9N0A4 100-212

17. Pf GST [102442] (1 species)
    cannot be assigned to any of the known GST classes

    • Species Malarial parasite (Plasmodium falciparum) [TaxId:5833] [102443] (4 PDB entries)

18. Yeast prion protein ure2p, nitrogen regulation fragment [52886] (1 species)
    similar to class phi enzymes

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52887] (8 PDB entries)

More info for Family c.47.1.5: Glutathione S-transferase (GST), N-terminal domain

Timeline for Family c.47.1.5: Glutathione S-transferase (GST), N-terminal domain:

• Family c.47.1.5: Glutathione S-transferase (GST), N-terminal domain first appeared (with stable ids) in SCOP 1.55, called Family c.47.1.5: Glutathione S-transferases, N-terminal domain
  
• Family c.47.1.5: Glutathione S-transferase (GST), N-terminal domain appears in SCOP 1.73
  
• Family c.47.1.5: Glutathione S-transferase (GST), N-terminal domain appears in SCOPe 2.01
  
• Family c.47.1.5: Glutathione S-transferase (GST), N-terminal domain appears in the current release, SCOPe 2.08