Class c: Alpha and beta proteins (a/b) [51349] (147 folds) |
Fold c.47: Thioredoxin fold [52832] (2 superfamilies) core: 3 layers, a/b/a; mixed beta-sheet of 4 strands, order 4312; strand 3 is antiparallel to the rest |
Superfamily c.47.1: Thioredoxin-like [52833] (24 families) |
c.47.1.1: Thioltransferase [52834] (16 proteins) |
c.47.1.2: PDI-like [52849] (2 proteins) duplication: contains two tandem repeats of this fold |
c.47.1.3: Calsequestrin [52855] (1 protein) duplication: contains three tandem repeats of this fold |
c.47.1.5: Glutathione S-transferase (GST), N-terminal domain [52862] (18 proteins) |
c.47.1.6: Phosducin [52888] (1 protein) |
c.47.1.7: ERP29 N domain-like [52892] (2 proteins) |
c.47.1.8: spliceosomal protein U5-15Kd [52895] (2 proteins) |
c.47.1.9: DsbC/DsbG C-terminal domain-like [52898] (2 proteins) elaborated common fold |
c.47.1.10: Glutathione peroxidase-like [52901] (29 proteins) |
c.47.1.11: Thioredoxin-like 2Fe-2S ferredoxin [52918] (1 protein) |
c.47.1.12: ArsC-like [69518] (4 proteins) Pfam PF03960 |
c.47.1.13: DsbA-like [100953] (4 proteins) contains an all-alpha subdomain insertion |
c.47.1.14: SH3BGR (SH3-binding, glutamic acid-rich protein-like) [102446] (1 protein) related to glutaredoxin 1 (GRX1) but lacks both conserved cysteine residues |
c.47.1.15: KaiB-like [102449] (3 proteins) Pfam PF07689; contains members with alternative folds |
c.47.1.16: Txnl5-like [110612] (1 protein) Pfam PF06110 |
c.47.1.17: YuzD-like [117605] (1 protein) Pfam PF07315 |
c.47.1.18: YKR049C-like [142395] (1 protein) Pfam PF07955; DUF1687; contains an all-alpha insert subdomain |
c.47.1.19: Atu2684-like [142398] (1 protein) Pfam PF06764; DUF1223; contains extra C-terminal domain of Immunoglobulin-like fold (48725), intimately associated with the N-terminal thioredixin-like domain and contributing to the active site |
c.47.1.20: HyaE-like [142401] (2 proteins) Pfam PF07449; have evolved a different function; contains no conserved cysteine residues |
c.47.1.21: NQO2-like [142405] (1 protein) complex I 24 kDa subunit; contains 2Fe-2S cluster in the active site; includes extra N-terminal four-helical bundle |
c.47.1.22: Mitochondrial ribosomal protein L51/S25/CI-B8 domain [142408] (1 protein) Pfam PF05047; "minimalized" version of the thioredoxin-like fold; variable positions for cysteine residues in the putative active site |
c.47.1.23: Selenoprotein W-related [142411] (4 proteins) Pfam PF05169; "minimalized" version of the thioredoxin-like fold |
c.47.1.24: UAS domain [159589] (1 protein) SMART 00594 |
c.47.1.0: automated matches [191312] (1 protein) not a true family |
Timeline for Superfamily c.47.1: Thioredoxin-like: