Lineage for Superfamily c.47.1: Thioredoxin-like

  1. Root: SCOP 1.75
  2. 814173Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 833461Fold c.47: Thioredoxin fold [52832] (2 superfamilies)
    core: 3 layers, a/b/a; mixed beta-sheet of 4 strands, order 4312; strand 3 is antiparallel to the rest
  4. 833462Superfamily c.47.1: Thioredoxin-like [52833] (23 families) (S)

Families:

  1. 833463c.47.1.1: Thioltransferase [52834] (15 proteins)
  2. 833670c.47.1.2: PDI-like [52849] (2 proteins)
    duplication: contains two tandem repeats of this fold
  3. 833716c.47.1.3: Calsequestrin [52855] (1 protein)
    duplication: contains three tandem repeats of this fold
  4. 833722c.47.1.5: Glutathione S-transferase (GST), N-terminal domain [52862] (18 proteins)
  5. 834273c.47.1.6: Phosducin [52888] (1 protein)
  6. 834281c.47.1.7: ERP29 N domain-like [52892] (2 proteins)
  7. 834296c.47.1.8: spliceosomal protein U5-15Kd [52895] (1 protein)
  8. 834304c.47.1.9: DsbC/DsbG C-terminal domain-like [52898] (2 proteins)
    elaborated common fold
  9. 834330c.47.1.10: Glutathione peroxidase-like [52901] (28 proteins)
  10. 834694c.47.1.11: Thioredoxin-like 2Fe-2S ferredoxin [52918] (1 protein)
  11. 834705c.47.1.12: ArsC-like [69518] (3 proteins)
    Pfam PF03960
  12. 834717c.47.1.13: DsbA-like [100953] (3 proteins)
    contains an all-alpha subdomain insertion
  13. 834765c.47.1.14: SH3BGR (SH3-binding, glutamic acid-rich protein-like) [102446] (1 protein)
    related to glutaredoxin 1 (GRX1) but lacks both conserved cysteine residues
  14. 834771c.47.1.15: KaiB-like [102449] (2 proteins)
    Pfam PF07689; contains members with alternative folds
  15. 834780c.47.1.16: Txnl5-like [110612] (1 protein)
    Pfam PF06110
  16. 834786c.47.1.17: YuzD-like [117605] (1 protein)
    Pfam PF07315
  17. 834790c.47.1.18: YKR049C-like [142395] (1 protein)
    Pfam PF07955; DUF1687; contains an all-alpha insert subdomain
  18. 834794c.47.1.19: Atu2684-like [142398] (1 protein)
    Pfam PF06764; DUF1223; contains extra C-terminal domain of Immunoglobulin-like fold ((48725)), intimately associated with the N-terminal thioredixin-like domain and contributing to the active site
  19. 834798c.47.1.20: HyaE-like [142401] (1 protein)
    Pfam PF07449; have evolved a different function; contains no conserved cysteine residues
  20. 834808c.47.1.21: NQO2-like [142405] (1 protein)
    complex I 24 kDa subunit; contains 2Fe-2S cluster in the active site; includes extra N-terminal four-helical bundle
  21. 834815c.47.1.22: Mitochondrial ribosomal protein L51/S25/CI-B8 domain [142408] (1 protein)
    Pfam PF05047; "minimalized" version of the thioredoxin-like fold; variable positions for cysteine residues in the putative active site
  22. 834819c.47.1.23: Selenoprotein W-related [142411] (3 proteins)
    Pfam PF05169; "minimalized" version of the thioredoxin-like fold
  23. 834832c.47.1.24: UAS domain [159589] (1 protein)
    SMART 00594

More info for Superfamily c.47.1: Thioredoxin-like

Timeline for Superfamily c.47.1: Thioredoxin-like: