Class c: Alpha and beta proteins (a/b) [51349] (121 folds) |
Fold c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily) core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1432 |
Superfamily c.45.1: (Phosphotyrosine protein) phosphatases II [52799] (2 families) share with the family I the common active site structure with a circularly permuted topology |
Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases [52805] (3 proteins) has an extension to the beta-sheet of 3 antiparallel strands before strand 4 |
Protein Tyrosine phosphatase [52806] (8 species) |
Human (Homo sapiens), 1B [TaxId:9606] [52807] (48 PDB entries) |
Domain d1a5y__: 1a5y - [32673] cysteinyl-phosphate intermediate |
Domain d1aax__: 1aax - [32657] complexed with bpm, mo6; mutant |
Domain d1bzca_: 1bzc A: [32670] complexed with tpi |
Domain d1bzha_: 1bzh A: [32664] complexed with inh |
Domain d1bzja_: 1bzj A: [32667] complexed with inh |
Domain d1c83a_: 1c83 A: [32660] complexed with oai |
Domain d1c84a_: 1c84 A: [32671] complexed with 761 |
Domain d1c85a_: 1c85 A: [32674] complexed with oba |
Domain d1c86a_: 1c86 A: [32668] complexed with opa; mutant |
Domain d1c87a_: 1c87 A: [32663] complexed with opa |
Domain d1c88a_: 1c88 A: [32659] complexed with ota |
Domain d1ecva_: 1ecv A: [32661] complexed with 878, act |
Domain d1eena_: 1een A: [32658] complexed with acy, mg, pbf; mutant |
Domain d1eeoa_: 1eeo A: [32655] complexed with mg; mutant |
Domain d1g1fa_: 1g1f A: [32662] mutant |
Domain d1g1ga_: 1g1g A: [32669] mutant |
Domain d1g1ha_: 1g1h A: [32672] mutant |
Domain d1g7fa_: 1g7f A: [60330] complexed with inz |
Domain d1g7ga_: 1g7g A: [60331] complexed with inx |
Domain d1gfya_: 1gfy A: [32666] complexed with col; mutant |
Domain d1i57a_: 1i57 A: [61772] complexed with cl, mg; mutant |
Domain d1jf7a_: 1jf7 A: [66619] |
Domain d1jf7b_: 1jf7 B: [66620] complexed with tbh |
Domain d1kaka_: 1kak A: [72253] complexed with fnp |
Domain d1kava_: 1kav A: [72266] complexed with fep |
Domain d1l8ga_: 1l8g A: [73689] complexed with dbd |
Domain d1lqfa_: 1lqf A: [74187] |
Domain d1lqfb_: 1lqf B: [74188] |
Domain d1lqfc_: 1lqf C: [74189] |
Domain d1lqfd_: 1lqf D: [74190] complexed with bgd |
Domain d1n6wa_: 1n6w A: [80212] complexed with acy, mg, sna |
Domain d1nl9a_: 1nl9 A: [85847] complexed with 989 |
Domain d1nnya_: 1nny A: [85912] complexed with 515 |
Domain d1no6a_: 1no6 A: [85922] complexed with 794 |
Domain d1nwea_: 1nwe A: [86298] complexed with fg1; mutant |
Domain d1nwla_: 1nwl A: [86300] complexed with 964, mo6; mutant |
Domain d1nz7a_: 1nz7 A: [86443] complexed with 901 |
Domain d1oemx_: 1oem X: [86916] |
Domain d1oeox_: 1oeo X: [86917] complexed with ocs |
Domain d1oesa_: 1oes A: [86920] complexed with mg |
Domain d1oeta_: 1oet A: [86921] complexed with cea, mg |
Domain d1oeua_: 1oeu A: [86922] complexed with csw, mg |
Domain d1oeva_: 1oev A: [86923] complexed with mg, ocs |
Domain d1onya_: 1ony A: [87180] complexed with 588 |
Domain d1onza_: 1onz A: [87181] complexed with 968 |
Domain d1ph0a_: 1ph0 A: [88074] complexed with 418 |
Domain d1ptta_: 1ptt A: [32677] complexed with ace, phs; mutant |
Domain d1ptua_: 1ptu A: [32675] complexed with nh2, phs; mutant |
Domain d1ptva_: 1ptv A: [32665] complexed with phs; mutant |
Domain d1pty__: 1pty - [32656] complexed with mo6; mutant |
Domain d2hnp__: 2hnp - [32678] |
Domain d2hnq__: 2hnq - [32676] complexed with wo4 |
Human (Homo sapiens), mu [TaxId:9606] [52808] (1 PDB entry) receptor protein tyrosine phosphatase mu, domain 1 |
Domain d1rpma_: 1rpm A: [32679] |
Domain d1rpmb_: 1rpm B: [32680] |
Human (Homo sapiens), shp-1 [TaxId:9606] [52811] (2 PDB entries) |
Domain d1fpra_: 1fpr A: [59949] complex with an in vitro peptide substrate py469 derived from shps-1, chain B mutant |
Domain d1gwz__: 1gwz - [32685] |
Human (Homo sapiens), shp-2 [TaxId:9606] [52810] (1 PDB entry) |
Domain d2shpa1: 2shp A:219-525 [32683] Other proteins in same PDB: d2shpa2, d2shpa3, d2shpb2, d2shpb3 |
Domain d2shpb1: 2shp B:219-525 [32684] Other proteins in same PDB: d2shpa2, d2shpa3, d2shpb2, d2shpb3 contains tandem repeat of two SH2 domains in the N-terminal region complexed with cat; mutant |
Human (Homo sapiens), T-cell [TaxId:9606] [75233] (1 PDB entry) non-receptor type 2 |
Domain d1l8ka_: 1l8k A: [73691] |
Mouse (Mus musculus) [TaxId:10090] [52809] (1 PDB entry) receptor protein tyrosine phosphatase alpha, domain 1 |
Domain d1yfoa_: 1yfo A: [32681] |
Domain d1yfob_: 1yfo B: [32682] |
Mouse (Mus musculus), ptp-sl/br7 [TaxId:10090] [64051] (1 PDB entry) |
Domain d1jlna_: 1jln A: [63172] |
Yersinia enterocolitica [TaxId:630] [52812] (5 PDB entries) |
Domain d1lyva_: 1lyv A: [74348] complexed with cl, po4; mutant |
Domain d1ypta_: 1ypt A: [32686] |
Domain d1yptb_: 1ypt B: [32687] mutant |
Domain d1ytn__: 1ytn - [32688] complexed with no3 |
Domain d1yts__: 1yts - [32690] complexed with so4; mutant |
Domain d1ytw__: 1ytw - [32689] complexed with so4, wo4 |
Timeline for Protein Tyrosine phosphatase from c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases: