Lineage for Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases

  1. Root: SCOP 1.63
  2. 235644Class c: Alpha and beta proteins (a/b) [51349] (117 folds)
  3. 244631Fold c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1432
  4. 244632Superfamily c.45.1: (Phosphotyrosine protein) phosphatases II [52799] (2 families) (S)
    share with the family I the common active site structure with a circularly permuted topology
  5. 244660Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases [52805] (3 proteins)
    has an extension to the beta-sheet of 3 antiparallel strands before strand 4

Proteins:

  1. 244661RPTP Lar [52815] (1 species)
    duplication: tandem repeat of the phosphatase domain
  2. 244667SptP tyrosine phosphatase, catalytic domain [52813] (1 species)
  3. 244671Tyrosine phosphatase [52806] (8 species)
    1. 244672Species Human (Homo sapiens), 1B [TaxId:9606] [52807] (33 PDB entries)
    2. 244710Species Human (Homo sapiens), mu [TaxId:9606] [52808] (1 PDB entry)
      receptor protein tyrosine phosphatase mu, domain 1
    3. 244713Species Human (Homo sapiens), shp-1 [TaxId:9606] [52811] (2 PDB entries)
    4. 244716Species Human (Homo sapiens), shp-2 [TaxId:9606] [52810] (1 PDB entry)
    5. 244719Species Human (Homo sapiens), T-cell [TaxId:9606] [75233] (1 PDB entry)
      non-receptor type 2
    6. 244721Species Mouse (Mus musculus) [TaxId:10090] [52809] (1 PDB entry)
      receptor protein tyrosine phosphatase alpha, domain 1
    7. 244724Species Mouse (Mus musculus), ptp-sl/br7 [TaxId:10090] [64051] (1 PDB entry)
    8. 244726Species Yersinia enterocolitica [TaxId:630] [52812] (5 PDB entries)

More info for Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases

Timeline for Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases: