SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family c.37.1.14: RNA helicase

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2109203Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
  4. 2109204Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (26 families) (S)
    division into families based on beta-sheet topologies
  5. 2113070Family c.37.1.14: RNA helicase [52724] (4 protein domains)
    duplication: consists of two similar domains, one binds NTP and the other binds RNA; also contains an all-alpha subdomain in the C-terminal extension

Protein Domains:

  1. 2113071Dengue virus helicase [142328] (1 species)
  2. 2113081HCV helicase domain [52725] (1 species)
  3. 2113143YFV helicase domain [142330] (1 species)
  4. 2113149automated matches [226986] (7 species)
    not a true protein
    1. 2113150Species Dengue virus 4 [TaxId:408688] [230921] (9 PDB entries)
    2. 2113166Species Hepatitis c virus (isolate taiwan) [TaxId:31645] [225628] (1 PDB entry)
    3. 2113168Species Hepatitis C virus [TaxId:11103] [311460] (2 PDB entries)
    4. 2113172Species West nile virus [TaxId:11078] [255564] (1 PDB entry)
    5. 2274109Species Hepatitis c virus genotype 1b (isolate con1) [TaxId:333284] [317410] (1 PDB entry)
    6. 2274507Species Zika virus [TaxId:64320] [317808] (7 PDB entries)
    7. 2283961Species Zika virus (strain mr 766) [TaxId:64320] [327262] (1 PDB entry)

More info for Family c.37.1.14: RNA helicase

Timeline for Family c.37.1.14: RNA helicase: