SCOP 1.75: Family c.37.1.10: Nitrogenase iron protein-like

Lineage for Family c.37.1.10: Nitrogenase iron protein-like

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (24 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.10: Nitrogenase iron protein-like [52652] (15 proteins)
   core: parallel beta-sheet of 7 strands; order 3241567

Proteins:

1. Adenylosuccinate synthetase, PurA [52655] (5 species)
   common fold is interrupted by an all-alpha subdomain, residues 100-200

   1. Species Bread wheat (Triticum aestivum) [TaxId:4565] [52658] (1 PDB entry)

   2. Species Escherichia coli [TaxId:562] [52656] (24 PDB entries)

   3. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [102372] (1 PDB entry)

   4. Species Mouse (Mus musculus) [TaxId:10090] [69491] (9 PDB entries)

   5. Species Mouse-ear cress (Arabidopsis thaliana) [TaxId:3702] [52657] (1 PDB entry)

2. Arsenite-translocating ATPase ArsA [52668] (1 species)
   Duplication: consists of two domains of this fold arranged as the NIP subunits in the dimer

   • Species Escherichia coli [TaxId:562] [52669] (4 PDB entries)

3. ATP(GTP)-binding protein PAB0955 [142297] (1 species)
   PYRAB14380; belongs to Pfam PF03029

   • Species Pyrococcus abyssi [TaxId:29292] [142298] (7 PDB entries)
     Uniprot Q9UYR9 30-273

4. Cell division regulator MinD [64019] (3 species)

   1. Species Archaeon Archaeoglobus fulgidus [TaxId:2234] [64020] (1 PDB entry)

   2. Species Archaeon Pyrococcus furiosus [TaxId:2261] [64021] (2 PDB entries)

   3. Species Archaeon Pyrococcus horikoshii [TaxId:53953] [64022] (1 PDB entry)

5. CTP synthase PyrG, N-terminal domain [110551] (3 species)

   1. Species Escherichia coli [TaxId:562] [110552] (1 PDB entry)
      Uniprot P08398

   2. Species Human (Homo sapiens) [TaxId:9606] [159561] (1 PDB entry)
      Uniprot Q5VW67 1-273

   3. Species Thermus thermophilus [TaxId:274] [110553] (3 PDB entries)
      Uniprot Q5SIA8

6. Dethiobiotin synthetase [52653] (1 species)

   • Species Escherichia coli [TaxId:562] [52654] (13 PDB entries)

7. Formyltetrahydrofolate synthetase [52659] (1 species)
   modified P-loop; there are many insertions in the common fold

   • Species Moorella thermoacetica [TaxId:1525] [52660] (3 PDB entries)

8. GTPase domain of the signal recognition particle receptor FtsY [52666] (3 species)

   1. Species Escherichia coli [TaxId:562] [52667] (2 PDB entries)

   2. Species Thermotoga maritima [TaxId:2336] [110550] (1 PDB entry)
      Uniprot Q9WZ40

   3. Species Thermus aquaticus [TaxId:271] [102374] (5 PDB entries)

9. GTPase domain of the signal sequence recognition protein Ffh [52664] (3 species)

   1. Species Archaeon Acidianus ambivalens [TaxId:2283] [64023] (2 PDB entries)

   2. Species Archaeon Sulfolobus solfataricus [TaxId:2287] [102373] (2 PDB entries)

   3. Species Thermus aquaticus [TaxId:271] [52665] (18 PDB entries)

10. Hypothetical protein TM0796 [142299] (1 species)
    member of Pfam PF07755; DUF1611; contains extra N-terminal alpha/beta fold of Rossmann-fold topology, parallel beta-sheet, strand order 312456

    • Species Thermotoga maritima [TaxId:2336] [142300] (1 PDB entry)
      Uniprot Q9WZQ3 1-338

11. Hypothetical protein YjiA, N-terminal domain [89671] (1 species)
    homologue of the cobalamin biosynthesis protein CobW

    • Species Escherichia coli [TaxId:562] [89672] (1 PDB entry)

12. LAO/AO transport system kinase ArgK [159562] (1 species)
    member of Pfam PF03308; contains extra N-terminal 3-helical bundle and extra C-terminal helical dimerisation domain

    • Species Escherichia coli [TaxId:562] [159563] (1 PDB entry)
      Uniprot P27254 1-327

13. Metallochaperone MeaB [159564] (1 species)
    ArgK-like (sub)family; Pfam PF03308

    • Species Methylobacterium extorquens [TaxId:408] [159565] (2 PDB entries)
      Uniprot Q8RPA0 5-327

14. Molybdopterin-guanine dinucleotide biosynthesis protein MobB [89673] (2 species)
    forms segment-swapped dimer

    1. Species Bacillus stearothermophilus [TaxId:1422] [117539] (1 PDB entry)
       Uniprot Q5L1X2 # 91% sequence identity

    2. Species Escherichia coli [TaxId:562] [89674] (2 PDB entries)

15. Nitrogenase iron protein [52661] (2 species)

    1. Species Azotobacter vinelandii [TaxId:354] [52662] (15 PDB entries)

    2. Species Clostridium pasteurianum [TaxId:1501] [52663] (1 PDB entry)

More info for Family c.37.1.10: Nitrogenase iron protein-like

Timeline for Family c.37.1.10: Nitrogenase iron protein-like:

• Family c.37.1.10: Nitrogenase iron protein-like first appeared (with stable ids) in SCOP 1.55
  
• Family c.37.1.10: Nitrogenase iron protein-like appears in SCOP 1.73
  
• Family c.37.1.10: Nitrogenase iron protein-like appears in SCOPe 2.01
  
• Family c.37.1.10: Nitrogenase iron protein-like appears in the current release, SCOPe 2.08