Lineage for Family c.37.1.8: G proteins

  1. Root: SCOP 1.65
  2. 305035Class c: Alpha and beta proteins (a/b) [51349] (121 folds)
  3. 313180Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
  4. 313181Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (21 families) (S)
    division into families based on beta-sheet topologies
  5. 313510Family c.37.1.8: G proteins [52592] (35 proteins)
    core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest

Proteins:

  1. 313511ADP-ribosylation factor [52614] (7 species)
    1. 313512Species Baker's yeast (Saccharomyces cerevisiae), ARF2 [TaxId:4932] [82401] (1 PDB entry)
    2. 313514Species Baker's yeast (Saccharomyces cerevisiae), ARL1 [TaxId:4932] [82402] (1 PDB entry)
    3. 313517Species Human (Homo sapiens), ARF1 [TaxId:9606] [52615] (3 PDB entries)
    4. 313523Species Human (Homo sapiens), ARF6 [TaxId:9606] [52617] (2 PDB entries)
    5. 313527Species Mouse (Mus musculus), ARL2 [TaxId:10090] [75203] (3 PDB entries)
    6. 313531Species Mouse (Mus musculus), ARL3 [TaxId:10090] [52618] (1 PDB entry)
    7. 313533Species Rat (Rattus norvegicus), ARF1 [TaxId:10116] [52616] (2 PDB entries)
  2. 313537CDC42 [52619] (1 species)
  3. 313564cH-p21 Ras protein [52593] (1 species)
  4. 313618Chloroplast protein translocon GTPase Toc34 [69485] (1 species)
  5. 313623Dynamin G domain [69488] (1 species)
    the family common core is decorated with large insertions
  6. 313627Elongation factor 2 (eEF-2), N-terminal (G) domain [82404] (1 species)
  7. 313632Elongation factor eEF-1alpha, N-terminal (G) domain [52631] (2 species)
    eukaryotic and archaeal homologue of EF-Tu
    1. 313633Species Archaeon Sulfolobus solfataricus [TaxId:2287] [69487] (1 PDB entry)
    2. 313636Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52632] (4 PDB entries)
  8. 313641Elongation factor G (EF-G), N-terminal (G) domain [52633] (1 species)
    has internal nucleotide exchange factor built in as an insertion subdomain
  9. 313648Elongation factor Tu (EF-Tu), N-terminal (G) domain [52626] (4 species)
    1. 313649Species Cow (Bos taurus), mitochondrial [TaxId:9913] [52630] (1 PDB entry)
    2. 313654Species Escherichia coli [TaxId:562] [52627] (6 PDB entries)
    3. 313665Species Thermus aquaticus [TaxId:271] [52628] (4 PDB entries)
    4. 313674Species Thermus thermophilus [TaxId:274] [52629] (3 PDB entries)
  10. 313682GTPase Era, N-terminal domain [52637] (1 species)
  11. 313686Initiation factor eIF2 gamma subunit, N-terminal (G) domain [75204] (1 species)
    includes rubredoxin-like zinc finger insert domain, res. 56-83
  12. 313693Initiation factor IF2/eIF5b, N-terminal (G) domain [52635] (1 species)
  13. 313698Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain [52639] (1 species)
  14. 313702Obg GTP-binding protein C-terminal domain [82408] (1 species)
  15. 313706Probable GTPase Der, N-terminal and middle domains [82406] (1 species)
    member of EngA subfamily of GTPases; contains two G domains
  16. 313710Probable GTPase EngB [89667] (1 species)
  17. 313714Probable GTPase YlqF [89669] (1 species)
    naturally occuring circular permutation of G-domain; includes C-terminal all-alpha subdomain
  18. 313717Rab-related protein Sec4 [52607] (1 species)
  19. 313725Rab-related protein ypt7p [75199] (1 species)
  20. 313729Rab3a [52601] (1 species)
  21. 313733Rab5a [82399] (1 species)
  22. 313743Rab5c [52603] (1 species)
  23. 313746Rab6 [52605] (1 species)
  24. 313749Rac [52595] (1 species)
  25. 313766Ran [52609] (2 species)
    1. 313767Species Dog (Canis familiaris) [TaxId:9615] [52610] (5 PDB entries)
    2. 313780Species Human (Homo sapiens) [TaxId:9606] [52611] (6 PDB entries)
  26. 313796Rap1A [52597] (1 species)
  27. 313800Rap2a [52599] (1 species)
  28. 313806Ras-related protein RalA [89662] (1 species)
  29. 313810RhoA [52612] (1 species)
  30. 313825RhoE (RND3) [75201] (1 species)
  31. 313830SAR1 [69483] (2 species)
    1. 313831Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [82403] (1 PDB entry)
    2. 313834Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [69484] (1 PDB entry)
  32. 313837Signal recognition particle receptor beta-subunit [89664] (1 species)
  33. 313840Transducin (alpha subunit) [52623] (2 species)
    common fold is interrupted with an all-alpha domain
    1. 313841Species Cow (Bos taurus) [TaxId:9913] [52624] (11 PDB entries)
    2. 313858Species Rat (Rattus norvegicus) [TaxId:10116] [52625] (18 PDB entries)
  34. 313881YchF GTP-binding protein N-terminal domain [82410] (2 species)
    Member of the Obg family of GTPases; contains an alpha-hairpin insert subdomain
    1. 313882Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [82411] (1 PDB entry)
    2. 313884Species Haemophilus influenzae [TaxId:727] [89666] (1 PDB entry)
      HI0393
  35. 313887Ypt51 [52621] (1 species)

More info for Family c.37.1.8: G proteins

Timeline for Family c.37.1.8: G proteins: