Lineage for Family c.37.1.8: G proteins

  1. Root: SCOPe 2.08
  2. 2826024Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2865683Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
  4. 2865684Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (27 families) (S)
    division into families based on beta-sheet topologies
  5. 2866675Family c.37.1.8: G proteins [52592] (81 proteins)
    core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest

Proteins:

  1. 2866676ADP-ribosylation factor [52614] (17 species)
    1. 2866677Species Baker's yeast (Saccharomyces cerevisiae), ARF2 [TaxId:4932] [82401] (1 PDB entry)
    2. 2866679Species Baker's yeast (Saccharomyces cerevisiae), ARL1 [TaxId:4932] [82402] (1 PDB entry)
    3. 2866682Species Human (Homo sapiens) [TaxId:9606] [142220] (2 PDB entries)
    4. 2866686Species Human (Homo sapiens), ARF1 [TaxId:9606] [52615] (14 PDB entries)
      Uniprot P32889
    5. 2866711Species Human (Homo sapiens), ARF4 [TaxId:9606] [142217] (1 PDB entry)
      Uniprot P18085 3-177
    6. 2866714Species Human (Homo sapiens), ARF6 [TaxId:9606] [52617] (5 PDB entries)
    7. 2866721Species Human (Homo sapiens), ARL1 [TaxId:9606] [102364] (4 PDB entries)
    8. 2866732Species Human (Homo sapiens), ARL5A [TaxId:9606] [142218] (1 PDB entry)
      Uniprot Q9Y689 2-178
    9. 2866734Species Human (Homo sapiens), ARL5B [TaxId:9606] [142221] (1 PDB entry)
      Uniprot Q96KC2 6-173
    10. 2866736Species Human (Homo sapiens), ARL8A [TaxId:9606] [142219] (1 PDB entry)
      Uniprot Q96BM9 18-181
    11. 2866738Species Human (Homo sapiens), ARL8B [TaxId:9606] [142222] (1 PDB entry)
      Uniprot Q9NVJ2 18-182
    12. 2866740Species Mouse (Mus musculus) [TaxId:10090] [225429] (3 PDB entries)
    13. 2866747Species Mouse (Mus musculus), ARL2 [TaxId:10090] [75203] (6 PDB entries)
    14. 2866761Species Mouse (Mus musculus), ARL3 [TaxId:10090] [52618] (3 PDB entries)
    15. 2866767Species Norway rat (Rattus norvegicus), ARF1 [TaxId:10116] [52616] (2 PDB entries)
    16. 2866771Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [189615] (1 PDB entry)
    17. 3084921Species Homo sapiens [TaxId:9606] [421238] (1 PDB entry)
  2. 2866774CDC42 [52619] (2 species)
    1. 2866775Species Human (Homo sapiens) [TaxId:9606] [52620] (34 PDB entries)
    2. 2866826Species Mouse (Mus musculus) [TaxId:10090] [159559] (2 PDB entries)
  3. 2866830Centaurin gamma 1, G domain [142249] (1 species)
  4. 2866833cH-p21 Ras protein [52593] (1 species)
  5. 2867056Chloroplast protein translocon GTPase Toc34 [69485] (1 species)
  6. 2867061di-Ras1 [142277] (1 species)
  7. 2867067di-Ras2 [142267] (1 species)
  8. 2867071Dynamin G domain [69488] (2 species)
    the family common core is decorated with large insertions
    1. 2867072Species Norway rat (Rattus norvegicus) [TaxId:10116] [142228] (1 PDB entry)
      Uniprot P21575 6-304
      Dynamin-1
    2. 2867074Species Slime mold (Dictyostelium discoideum) [TaxId:44689] [69489] (2 PDB entries)
  9. 2867077Elongation factor 2 (eEF-2), N-terminal (G) domain [82404] (2 species)
    1. 2867078Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [82405] (13 PDB entries)
      Uniprot P32324
    2. 2867104Species Human (Homo sapiens) [TaxId:9606] [268001] (1 PDB entry)
  10. 2867106Elongation factor eEF-1alpha, N-terminal (G) domain [52631] (2 species)
    eukaryotic and archaeal homologue of EF-Tu
    1. 2867107Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52632] (6 PDB entries)
    2. 2867114Species Sulfolobus solfataricus [TaxId:2287] [69487] (2 PDB entries)
      Uniprot P35021
  11. 2867119Elongation factor G (EF-G), N-terminal (G) domain [52633] (2 species)
    has internal nucleotide exchange factor built in as an insertion subdomain
    1. 2867120Species Thermus thermophilus [TaxId:274] [52634] (9 PDB entries)
      residues 160-252 comprise insertion subdomain
    2. 2867131Species Thermus thermophilus, EF-G-2 [TaxId:274] [142226] (2 PDB entries)
      Uniprot Q5SI76 1-267
      TTHA1498
  12. 2867134Elongation factor SelB, N-terminal domain [117537] (1 species)
  13. 2867148Elongation factor Tu (EF-Tu), N-terminal (G) domain [52626] (4 species)
    1. 2867149Species Cow (Bos taurus), mitochondrial [TaxId:9913] [52630] (2 PDB entries)
      Uniprot P49410 56-452
    2. 2867155Species Escherichia coli [TaxId:562] [52627] (11 PDB entries)
      Uniprot P02990
    3. 2867174Species Thermus aquaticus [TaxId:271] [52628] (4 PDB entries)
    4. 2867183Species Thermus thermophilus [TaxId:274] [52629] (4 PDB entries)
  14. 2867192Eukaryotic peptide chain release factor ERF2, G domain [110535] (1 species)
  15. 2867197Ferrous iron transport protein FeoB [419187] (1 species)
    includes C-terminal all-alpha subdomain, Pfam PF17910
  16. 2867216GTP-binding protein engB [142257] (1 species)
  17. 2867219GTP-binding protein GEM [142289] (1 species)
  18. 2867224GTP-binding protein PH0525 [142251] (1 species)
    Member of the Obg family of GTPases; contains an alpha-hairpin insert subdomain
  19. 2867227GTP-binding protein RheB [142275] (2 species)
    1. 2867228Species Human (Homo sapiens) [TaxId:9606] [142276] (9 PDB entries)
      Uniprot Q15382 3-169
    2. 2867252Species Norway rat (Rattus norvegicus) [TaxId:10116] [255395] (1 PDB entry)
  20. 2867254GTPase Era, N-terminal domain [52637] (3 species)
    1. 2867255Species Escherichia coli K-12 [TaxId:83333] [224886] (1 PDB entry)
    2. 2867258Species Escherichia coli [TaxId:562] [52638] (2 PDB entries)
    3. 2867262Species Thermus thermophilus [TaxId:274] [117533] (2 PDB entries)
      Uniprot Q5SM23
  21. 2867265GTPase Ytp1 [110544] (1 species)
  22. 2867269Initiation factor eIF2 gamma subunit, N-terminal (G) domain [75204] (3 species)
    includes rubredoxin-like zinc finger insert domain, res. 56-83, similar that of the Nop10-like family (144211)
    1. 2867270Species Methanococcus jannaschii [TaxId:2190] [102365] (1 PDB entry)
    2. 2867272Species Pyrococcus abyssi [TaxId:29292] [75205] (5 PDB entries)
    3. 2867278Species Sulfolobus solfataricus [TaxId:2287] [142227] (10 PDB entries)
      Uniprot Q980A5 2-206
  23. 2867296Initiation factor IF2/eIF5b, N-terminal (G) domain [52635] (1 species)
  24. 2867301Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain [52639] (1 species)
  25. 2867305Interferon-inducible GTPase [110546] (1 species)
    G domain is inserted in all-alpha domain
  26. 2867315Obg GTP-binding protein middle domain [82408] (2 species)
    1. 2867316Species Bacillus subtilis [TaxId:1423] [82409] (1 PDB entry)
    2. 2867319Species Thermus thermophilus [TaxId:274] [102368] (1 PDB entry)
      TT1381
  27. 2867321Pre-mRNA splicing factor Cwf10, N-terminal domain [346068] (1 species)
  28. 2867324Probable GTPase Der, N-terminal and middle domains [82406] (1 species)
    member of EngA subfamily of GTPases; contains two G domains
  29. 2867328Probable GTPase EngB [89667] (2 species)
    1. 2867329Species Bacillus subtilis [TaxId:1423] [110534] (3 PDB entries)
      Uniprot P38424
    2. 2867335Species Escherichia coli [TaxId:562] [89668] (1 PDB entry)
  30. 2867338Probable GTPase EngC (YjeQ), C-terminal domain [110542] (2 species)
    circularly permuted G-domain similar to B. sutilis YlqF; distinct extra C-terminal all-alpha subdomain
    1. 2867339Species Bacillus subtilis [TaxId:1423] [117534] (1 PDB entry)
      Uniprot O34530
    2. 2867341Species Thermotoga maritima [TaxId:2336] [110543] (1 PDB entry)
      Uniprot Q9X242 # TM1717
  31. 2867345Probable GTPase YlqF [89669] (1 species)
    naturally occurring circular permutation of G-domain; includes C-terminal all-alpha subdomain
  32. 2867348Probable tRNA modification GTPase TrmE (MnmE), G domain [102366] (1 species)
  33. 2867351r-Ras [142273] (1 species)
  34. 2867354r-Ras2 [142281] (1 species)
  35. 2867357Rab-22a [142253] (1 species)
  36. 2867361Rab-33b [142279] (1 species)
  37. 2867365Rab-related protein Sec4 [52607] (1 species)
  38. 2867374Rab-related protein ypt7p [75199] (1 species)
  39. 2867378Rab11a [102362] (2 species)
    1. 2867379Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [159558] (2 PDB entries)
    2. 2867385Species Human (Homo sapiens) [TaxId:9606] [102363] (4 PDB entries)
  40. 2867392Rab11b [142237] (1 species)
  41. 2867396Rab14 [142271] (1 species)
  42. 2867400Rab18 [142233] (1 species)
  43. 2867403Rab1a [142241] (1 species)
  44. 2867411Rab21 [142285] (1 species)
  45. 2867416Rab23 [142231] (1 species)
  46. 2867419Rab26 [142259] (1 species)
  47. 2867422Rab27b [142263] (2 species)
    1. 2867423Species Human (Homo sapiens) [TaxId:9606] [142264] (1 PDB entry)
      Uniprot O00194 4-189
    2. 2867426Species Mouse (Mus musculus) [TaxId:10090] [256388] (1 PDB entry)
  48. 2867429Rab2a [142265] (1 species)
  49. 2867432Rab2b [142287] (1 species)
  50. 2867435Rab30 [142239] (1 species)
  51. 2867438Rab31 [142235] (1 species)
  52. 2867441Rab3a [52601] (1 species)
  53. 2867445Rab4a [142247] (1 species)
  54. 2867451Rab5a [82399] (1 species)
  55. 2867473Rab5c [52603] (1 species)
  56. 2867479Rab6 [52605] (2 species)
    1. 2867480Species Human (Homo sapiens) [TaxId:9606] [142216] (1 PDB entry)
      Uniprot P20340 13-176
    2. 2867482Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [52606] (1 PDB entry)
  57. 2867484Rab7 [110540] (2 species)
    1. 2867485Species Human (Homo sapiens) [TaxId:9606] [142230] (2 PDB entries)
      Uniprot P51149 7-182
    2. 2867491Species Norway rat (Rattus norvegicus) [TaxId:10116] [110541] (4 PDB entries)
      Uniprot P09527
  58. 2867502Rab8a [142293] (2 species)
    1. 2867503Species Human (Homo sapiens) [TaxId:9606] [254870] (14 PDB entries)
    2. 2867538Species Mouse (Mus musculus) [TaxId:10090] [142294] (1 PDB entry)
      Uniprot P55258 3-175
  59. 2867541Rab9a [110537] (3 species)
    1. 2867542Species Dog (Canis familiaris) [TaxId:9615] [110538] (1 PDB entry)
      Uniprot P24408
    2. 2867545Species Human (Homo sapiens) [TaxId:9606] [110539] (1 PDB entry)
      Uniprot P51151 2-175 # 100% sequence identity do the dog protein (Uniprot P24408 2-175)
    3. 2867548Species Mouse (Mus musculus) [TaxId:10090] [142229] (2 PDB entries)
      Uniprot Q9R0M6 4-175
  60. 2867551Rac [52595] (1 species)
  61. 2867612Rac3 [142255] (1 species)
  62. 2867615Rad [142295] (1 species)
  63. 2867618Ran [52609] (2 species)
    1. 2867619Species Dog (Canis familiaris) [TaxId:9615] [52610] (9 PDB entries)
      Uniprot P62825
    2. 2867639Species Human (Homo sapiens) [TaxId:9606] [52611] (88 PDB entries)
  64. 2867753Rap1A [52597] (1 species)
  65. 2867757Rap2a [52599] (1 species)
  66. 2867763Ras-like estrogen-regulated growth inhibitor, RERG [142291] (1 species)
  67. 2867766Ras-related protein M-Ras (XRas) [142283] (1 species)
  68. 2867769Ras-related protein RalA [89662] (2 species)
    1. 2867770Species Cotton-top tamarin (Saguinus oedipus) [TaxId:9490] [117532] (3 PDB entries)
      Uniprot P63320 # 100% identical to the mouse and rat orthologs (Uniprot P63321 P63322)
    2. 2867777Species Human (Homo sapiens) [TaxId:9606] [89663] (5 PDB entries)
  69. 2867786RhoA [52612] (1 species)
  70. 2867850RhoB [142243] (1 species)
  71. 2867856RhoC [142245] (1 species)
  72. 2867863RhoE (RND3) [75201] (1 species)
  73. 2867868RhoQ [142261] (1 species)
  74. 2867872SAR1 [69483] (3 species)
    1. 2867873Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [82403] (2 PDB entries)
    2. 2867877Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [69484] (1 PDB entry)
    3. 2867880Species Human (Homo sapiens) [TaxId:9606] [142223] (1 PDB entry)
      Uniprot Q9NR31 13-198
  75. 2867883Signal recognition particle receptor beta-subunit [89664] (2 species)
    1. 2867884Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [89665] (1 PDB entry)
    2. 2867886Species Mouse (Mus musculus) [TaxId:10090] [142224] (2 PDB entries)
      Uniprot P47758 63-269
  76. 2867889Sulfate adenylate transferase subunit cysN/C, EF-Tu domain G-like domain [142269] (1 species)
  77. 2867892Transducin (alpha subunit) [52623] (4 species)
    common fold is interrupted with an all-alpha domain
    1. 2867893Species Cow (Bos taurus) [TaxId:9913] [52624] (18 PDB entries)
      Uniprot P04896 39-388
    2. 2867917Species Human (Homo sapiens) [TaxId:9606] [159560] (9 PDB entries)
    3. 2867934Species Mouse (Mus musculus) [TaxId:10090] [142225] (5 PDB entries)
      Uniprot P21279 38-66,184-354! Uniprot P27600 53-81,204-370! Uniprot P27601 47-75,202-372
    4. 2867943Species Norway rat (Rattus norvegicus) [TaxId:10116] [52625] (21 PDB entries)
      Uniprot P10824
  78. 2867970TrmE GTPase domain [117535] (1 species)
  79. 2867974YchF GTP-binding protein N-terminal domain [82410] (2 species)
    Member of the Obg family of GTPases; contains an alpha-hairpin insert subdomain
    1. 2867975Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [82411] (1 PDB entry)
    2. 2867977Species Haemophilus influenzae [TaxId:727] [89666] (1 PDB entry)
      HI0393
  80. 2867980Ypt51 [52621] (1 species)
  81. 2867983automated matches [190047] (37 species)
    not a true protein
    1. 2867984Species Aspergillus fumigatus [TaxId:330879] [368993] (1 PDB entry)
    2. 2867986Species Aspergillus fumigatus [TaxId:41122] [390209] (1 PDB entry)
    3. 2867988Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [187069] (9 PDB entries)
    4. 2868006Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [189771] (4 PDB entries)
    5. 2868013Species Candida albicans [TaxId:237561] [329047] (2 PDB entries)
    6. 2868022Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [187100] (2 PDB entries)
    7. 2868027Species Cryptosporidium parvum [TaxId:5807] [188236] (1 PDB entry)
    8. 2868029Species Dog (Canis familiaris) [TaxId:9615] [224975] (1 PDB entry)
    9. 2868032Species Entamoeba (Entamoeba histolytica) [TaxId:5759] [196360] (4 PDB entries)
    10. 2868040Species Entamoeba histolytica [TaxId:294381] [273048] (1 PDB entry)
    11. 2868043Species Escherichia coli K-12 [TaxId:83333] [256110] (3 PDB entries)
    12. 2868049Species Escherichia coli [TaxId:316385] [272313] (3 PDB entries)
    13. 2868056Species Escherichia coli [TaxId:331112] [343069] (2 PDB entries)
    14. 2868061Species Escherichia coli [TaxId:469008] [187117] (4 PDB entries)
    15. 2868073Species Escherichia coli [TaxId:511963] [419961] (1 PDB entry)
    16. 2868076Species Escherichia coli [TaxId:562] [419849] (3 PDB entries)
    17. 2868086Species Escherichia coli [TaxId:83333] [272301] (1 PDB entry)
    18. 2868089Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [189700] (1 PDB entry)
    19. 2868092Species Green alga (Chlamydomonas reinhardtii) [TaxId:3055] [369535] (1 PDB entry)
    20. 2868094Species Human (Homo sapiens) [TaxId:9606] [186768] (288 PDB entries)
    21. 2868656Species Klebsiella pneumoniae [TaxId:573] [419828] (4 PDB entries)
    22. 2868663Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [189514] (1 PDB entry)
    23. 2868665Species Mouse (Mus musculus) [TaxId:10090] [186896] (12 PDB entries)
    24. 2868684Species Norway rat (Rattus norvegicus) [TaxId:10116] [194536] (6 PDB entries)
    25. 2868694Species Oryza sativa [TaxId:39947] [259129] (1 PDB entry)
    26. 2868696Species Pea (Pisum sativum) [TaxId:3888] [188398] (1 PDB entry)
    27. 2868705Species Plasmodium falciparum [TaxId:36329] [188290] (1 PDB entry)
    28. 2868711Species Pyrococcus horikoshii OT3 [TaxId:70601] [187582] (1 PDB entry)
    29. 2868714Species Saccharolobus solfataricus [TaxId:2287] [385001] (2 PDB entries)
    30. 2868717Species Saccharomyces cerevisiae [TaxId:764097] [261066] (1 PDB entry)
    31. 2868719Species Sulfolobus solfataricus [TaxId:2287] [255781] (6 PDB entries)
    32. 2868735Species Sulfolobus solfataricus [TaxId:273057] [256083] (13 PDB entries)
    33. 2868753Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [188355] (9 PDB entries)
    34. 2868767Species Thermus aquaticus [TaxId:271] [254880] (1 PDB entry)
    35. 2868771Species Thermus thermophilus HB8 [TaxId:300852] [255082] (2 PDB entries)
    36. 2868774Species Thermus thermophilus [TaxId:274] [256283] (6 PDB entries)
    37. 2868781Species Turkey (Meleagris gallopavo) [TaxId:9103] [401071] (1 PDB entry)

More info for Family c.37.1.8: G proteins

Timeline for Family c.37.1.8: G proteins: