SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family c.37.1.8: G proteins

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2109203Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
  4. 2109204Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (26 families) (S)
    division into families based on beta-sheet topologies
  5. 2110099Family c.37.1.8: G proteins [52592] (79 protein domains)
    core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest

Protein Domains:

  1. 2110100ADP-ribosylation factor [52614] (16 species)
    1. 2110101Species Baker's yeast (Saccharomyces cerevisiae), ARF2 [TaxId:4932] [82401] (1 PDB entry)
    2. 2110103Species Baker's yeast (Saccharomyces cerevisiae), ARL1 [TaxId:4932] [82402] (1 PDB entry)
    3. 2110106Species Human (Homo sapiens) [TaxId:9606] [142220] (2 PDB entries)
    4. 2110110Species Human (Homo sapiens), ARF1 [TaxId:9606] [52615] (14 PDB entries)
      Uniprot P32889
    5. 2110135Species Human (Homo sapiens), ARF4 [TaxId:9606] [142217] (1 PDB entry)
      Uniprot P18085 3-177
    6. 2110138Species Human (Homo sapiens), ARF6 [TaxId:9606] [52617] (5 PDB entries)
    7. 2110145Species Human (Homo sapiens), ARL1 [TaxId:9606] [102364] (3 PDB entries)
    8. 2110154Species Human (Homo sapiens), ARL5A [TaxId:9606] [142218] (1 PDB entry)
      Uniprot Q9Y689 2-178
    9. 2110156Species Human (Homo sapiens), ARL5B [TaxId:9606] [142221] (1 PDB entry)
      Uniprot Q96KC2 6-173
    10. 2110158Species Human (Homo sapiens), ARL8A [TaxId:9606] [142219] (1 PDB entry)
      Uniprot Q96BM9 18-181
    11. 2110160Species Human (Homo sapiens), ARL8B [TaxId:9606] [142222] (1 PDB entry)
      Uniprot Q9NVJ2 18-182
    12. 2110162Species Mouse (Mus musculus) [TaxId:10090] [225429] (3 PDB entries)
    13. 2110169Species Mouse (Mus musculus), ARL2 [TaxId:10090] [75203] (5 PDB entries)
    14. 2110177Species Mouse (Mus musculus), ARL3 [TaxId:10090] [52618] (3 PDB entries)
    15. 2110181Species Norway rat (Rattus norvegicus), ARF1 [TaxId:10116] [52616] (2 PDB entries)
    16. 2110185Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [189615] (1 PDB entry)
  2. 2110188CDC42 [52619] (2 species)
    1. 2110189Species Human (Homo sapiens) [TaxId:9606] [52620] (30 PDB entries)
    2. 2110232Species Mouse (Mus musculus) [TaxId:10090] [159559] (1 PDB entry)
  3. 2110235Centaurin gamma 1, G domain [142249] (1 species)
  4. 2110238cH-p21 Ras protein [52593] (1 species)
  5. 2110367Chloroplast protein translocon GTPase Toc34 [69485] (1 species)
  6. 2110372di-Ras1 [142277] (1 species)
  7. 2110378di-Ras2 [142267] (1 species)
  8. 2110381Dynamin G domain [69488] (2 species)
    the family common core is decorated with large insertions
    1. 2110382Species Norway rat (Rattus norvegicus) [TaxId:10116] [142228] (1 PDB entry)
      Uniprot P21575 6-304
      Dynamin-1
    2. 2110384Species Slime mold (Dictyostelium discoideum) [TaxId:44689] [69489] (2 PDB entries)
  9. 2110387Elongation factor 2 (eEF-2), N-terminal (G) domain [82404] (2 species)
    1. 2110388Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [82405] (13 PDB entries)
      Uniprot P32324
    2. 2110414Species Human (Homo sapiens) [TaxId:9606] [268001] (1 PDB entry)
  10. 2110416Elongation factor eEF-1alpha, N-terminal (G) domain [52631] (2 species)
    eukaryotic and archaeal homologue of EF-Tu
    1. 2110417Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52632] (6 PDB entries)
    2. 2110424Species Sulfolobus solfataricus [TaxId:2287] [69487] (2 PDB entries)
      Uniprot P35021
  11. 2110429Elongation factor G (EF-G), N-terminal (G) domain [52633] (2 species)
    has internal nucleotide exchange factor built in as an insertion subdomain
    1. 2110430Species Thermus thermophilus [TaxId:274] [52634] (9 PDB entries)
      residues 160-252 comprise insertion subdomain
    2. 2110441Species Thermus thermophilus, EF-G-2 [TaxId:274] [142226] (2 PDB entries)
      Uniprot Q5SI76 1-267
      TTHA1498
  12. 2110444Elongation factor SelB, N-terminal domain [117537] (1 species)
  13. 2110458Elongation factor Tu (EF-Tu), N-terminal (G) domain [52626] (4 species)
    1. 2110459Species Cow (Bos taurus), mitochondrial [TaxId:9913] [52630] (2 PDB entries)
      Uniprot P49410 56-452
    2. 2110465Species Escherichia coli [TaxId:562] [52627] (10 PDB entries)
      Uniprot P02990
    3. 2110482Species Thermus aquaticus [TaxId:271] [52628] (4 PDB entries)
    4. 2110491Species Thermus thermophilus [TaxId:274] [52629] (4 PDB entries)
  14. 2110500Eukaryotic peptide chain release factor ERF2, G domain [110535] (1 species)
  15. 2110505GTP-binding protein engB [142257] (1 species)
  16. 2110508GTP-binding protein GEM [142289] (1 species)
  17. 2110513GTP-binding protein PH0525 [142251] (1 species)
    Member of the Obg family of GTPases; contains an alpha-hairpin insert subdomain
  18. 2110516GTP-binding protein RheB [142275] (2 species)
    1. 2110517Species Human (Homo sapiens) [TaxId:9606] [142276] (3 PDB entries)
      Uniprot Q15382 3-169
    2. 2110522Species Norway rat (Rattus norvegicus) [TaxId:10116] [255395] (1 PDB entry)
  19. 2110524GTPase Era, N-terminal domain [52637] (3 species)
    1. 2110525Species Escherichia coli K-12 [TaxId:83333] [224886] (1 PDB entry)
    2. 2110528Species Escherichia coli [TaxId:562] [52638] (2 PDB entries)
    3. 2110532Species Thermus thermophilus [TaxId:274] [117533] (2 PDB entries)
      Uniprot Q5SM23
  20. 2110535GTPase Ytp1 [110544] (1 species)
  21. 2110539Initiation factor eIF2 gamma subunit, N-terminal (G) domain [75204] (3 species)
    includes rubredoxin-like zinc finger insert domain, res. 56-83, similar that of the Nop10-like family (144211)
    1. 2110540Species Methanococcus jannaschii [TaxId:2190] [102365] (1 PDB entry)
    2. 2110542Species Pyrococcus abyssi [TaxId:29292] [75205] (5 PDB entries)
    3. 2110548Species Sulfolobus solfataricus [TaxId:2287] [142227] (10 PDB entries)
      Uniprot Q980A5 2-206
  22. 2110566Initiation factor IF2/eIF5b, N-terminal (G) domain [52635] (1 species)
  23. 2110571Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain [52639] (1 species)
  24. 2110575Interferon-inducible GTPase [110546] (1 species)
    G domain is inserted in all-alpha domain
  25. 2110585Obg GTP-binding protein middle domain [82408] (2 species)
    1. 2110586Species Bacillus subtilis [TaxId:1423] [82409] (1 PDB entry)
    2. 2110589Species Thermus thermophilus [TaxId:274] [102368] (1 PDB entry)
      TT1381
  26. 2110591Probable GTPase Der, N-terminal and middle domains [82406] (1 species)
    member of EngA subfamily of GTPases; contains two G domains
  27. 2110595Probable GTPase EngB [89667] (2 species)
    1. 2110596Species Bacillus subtilis [TaxId:1423] [110534] (3 PDB entries)
      Uniprot P38424
    2. 2110602Species Escherichia coli [TaxId:562] [89668] (1 PDB entry)
  28. 2110605Probable GTPase EngC (YjeQ), C-terminal domain [110542] (2 species)
    circularly permuted G-domain similar to B. sutilis YlqF; distinct extra C-terminal all-alpha subdomain
    1. 2110606Species Bacillus subtilis [TaxId:1423] [117534] (1 PDB entry)
      Uniprot O34530
    2. 2110608Species Thermotoga maritima [TaxId:2336] [110543] (1 PDB entry)
      Uniprot Q9X242 # TM1717
  29. 2110612Probable GTPase YlqF [89669] (1 species)
    naturally occurring circular permutation of G-domain; includes C-terminal all-alpha subdomain
  30. 2110615Probable tRNA modification GTPase TrmE (MnmE), G domain [102366] (1 species)
  31. 2110618r-Ras [142273] (1 species)
  32. 2110621r-Ras2 [142281] (1 species)
  33. 2110624Rab-22a [142253] (1 species)
  34. 2110628Rab-33b [142279] (1 species)
  35. 2110632Rab-related protein Sec4 [52607] (1 species)
  36. 2110641Rab-related protein ypt7p [75199] (1 species)
  37. 2110645Rab11a [102362] (2 species)
    1. 2110646Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [159558] (2 PDB entries)
    2. 2110652Species Human (Homo sapiens) [TaxId:9606] [102363] (4 PDB entries)
  38. 2110659Rab11b [142237] (1 species)
  39. 2110663Rab14 [142271] (1 species)
  40. 2110667Rab18 [142233] (1 species)
  41. 2110670Rab1a [142241] (1 species)
  42. 2110678Rab21 [142285] (1 species)
  43. 2110683Rab23 [142231] (1 species)
  44. 2110686Rab26 [142259] (1 species)
  45. 2110689Rab27b [142263] (2 species)
    1. 2110690Species Human (Homo sapiens) [TaxId:9606] [142264] (1 PDB entry)
      Uniprot O00194 4-189
    2. 2110693Species Mouse (Mus musculus) [TaxId:10090] [256388] (1 PDB entry)
  46. 2110696Rab2a [142265] (1 species)
  47. 2110699Rab2b [142287] (1 species)
  48. 2110702Rab30 [142239] (1 species)
  49. 2110705Rab31 [142235] (1 species)
  50. 2110708Rab3a [52601] (1 species)
  51. 2110712Rab4a [142247] (1 species)
  52. 2110718Rab5a [82399] (1 species)
  53. 2110740Rab5c [52603] (1 species)
  54. 2110746Rab6 [52605] (2 species)
    1. 2110747Species Human (Homo sapiens) [TaxId:9606] [142216] (1 PDB entry)
      Uniprot P20340 13-176
    2. 2110749Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [52606] (1 PDB entry)
  55. 2110751Rab7 [110540] (2 species)
    1. 2110752Species Human (Homo sapiens) [TaxId:9606] [142230] (2 PDB entries)
      Uniprot P51149 7-182
    2. 2110758Species Norway rat (Rattus norvegicus) [TaxId:10116] [110541] (4 PDB entries)
      Uniprot P09527
  56. 2110769Rab8a [142293] (2 species)
    1. 2110770Species Human (Homo sapiens) [TaxId:9606] [254870] (4 PDB entries)
    2. 2110785Species Mouse (Mus musculus) [TaxId:10090] [142294] (1 PDB entry)
      Uniprot P55258 3-175
  57. 2110788Rab9a [110537] (3 species)
    1. 2110789Species Dog (Canis familiaris) [TaxId:9615] [110538] (1 PDB entry)
      Uniprot P24408
    2. 2110792Species Human (Homo sapiens) [TaxId:9606] [110539] (1 PDB entry)
      Uniprot P51151 2-175 # 100% sequence identity do the dog protein (Uniprot P24408 2-175)
    3. 2110795Species Mouse (Mus musculus) [TaxId:10090] [142229] (2 PDB entries)
      Uniprot Q9R0M6 4-175
  58. 2110798Rac [52595] (1 species)
  59. 2110827Rac3 [142255] (1 species)
  60. 2110830Rad [142295] (1 species)
  61. 2110833Ran [52609] (2 species)
    1. 2110834Species Dog (Canis familiaris) [TaxId:9615] [52610] (10 PDB entries)
      Uniprot P62825
    2. 2110854Species Human (Homo sapiens) [TaxId:9606] [52611] (43 PDB entries)
  62. 2110924Rap1A [52597] (1 species)
  63. 2110928Rap2a [52599] (1 species)
  64. 2110934Ras-like estrogen-regulated growth inhibitor, RERG [142291] (1 species)
  65. 2110937Ras-related protein M-Ras (XRas) [142283] (1 species)
  66. 2110940Ras-related protein RalA [89662] (2 species)
    1. 2110941Species Cotton-top tamarin (Saguinus oedipus) [TaxId:9490] [117532] (3 PDB entries)
      Uniprot P63320 # 100% identical to the mouse and rat orthologs (Uniprot P63321 P63322)
    2. 2110948Species Human (Homo sapiens) [TaxId:9606] [89663] (5 PDB entries)
  67. 2110957RhoA [52612] (1 species)
  68. 2111001RhoB [142243] (1 species)
  69. 2111004RhoC [142245] (1 species)
  70. 2111011RhoE (RND3) [75201] (1 species)
  71. 2111016RhoQ [142261] (1 species)
  72. 2111020SAR1 [69483] (3 species)
    1. 2111021Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [82403] (2 PDB entries)
    2. 2111025Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [69484] (1 PDB entry)
    3. 2111028Species Human (Homo sapiens) [TaxId:9606] [142223] (1 PDB entry)
      Uniprot Q9NR31 13-198
  73. 2111031Signal recognition particle receptor beta-subunit [89664] (2 species)
    1. 2111032Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [89665] (1 PDB entry)
    2. 2111034Species Mouse (Mus musculus) [TaxId:10090] [142224] (2 PDB entries)
      Uniprot P47758 63-269
  74. 2111037Sulfate adenylate transferase subunit cysN/C, EF-Tu domain G-like domain [142269] (1 species)
  75. 2111040Transducin (alpha subunit) [52623] (4 species)
    common fold is interrupted with an all-alpha domain
    1. 2111041Species Cow (Bos taurus) [TaxId:9913] [52624] (18 PDB entries)
      Uniprot P04896 39-388
    2. 2111065Species Human (Homo sapiens) [TaxId:9606] [159560] (9 PDB entries)
    3. 2111082Species Mouse (Mus musculus) [TaxId:10090] [142225] (5 PDB entries)
      Uniprot P21279 38-66,184-354! Uniprot P27600 53-81,204-370! Uniprot P27601 47-75,202-372
    4. 2111091Species Norway rat (Rattus norvegicus) [TaxId:10116] [52625] (21 PDB entries)
      Uniprot P10824
  76. 2111118TrmE GTPase domain [117535] (1 species)
  77. 2111122YchF GTP-binding protein N-terminal domain [82410] (2 species)
    Member of the Obg family of GTPases; contains an alpha-hairpin insert subdomain
    1. 2111123Species Fission yeast (Schizosaccharomyces pombe) [TaxId:4896] [82411] (1 PDB entry)
    2. 2111125Species Haemophilus influenzae [TaxId:727] [89666] (1 PDB entry)
      HI0393
  78. 2111128Ypt51 [52621] (1 species)
  79. 2111131automated matches [190047] (28 species)
    not a true protein
    1. 2111132Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [187069] (9 PDB entries)
    2. 2111150Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [189771] (4 PDB entries)
    3. 2111157Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [187100] (2 PDB entries)
    4. 2111162Species Cryptosporidium parvum [TaxId:5807] [188236] (1 PDB entry)
    5. 2111164Species Dog (Canis familiaris) [TaxId:9615] [224975] (1 PDB entry)
    6. 2111167Species Entamoeba (Entamoeba histolytica) [TaxId:5759] [196360] (4 PDB entries)
    7. 2111175Species Entamoeba histolytica [TaxId:294381] [273048] (1 PDB entry)
    8. 2111178Species Escherichia coli K-12 [TaxId:83333] [256110] (3 PDB entries)
    9. 2111184Species Escherichia coli [TaxId:316385] [272313] (3 PDB entries)
    10. 2111191Species Escherichia coli [TaxId:469008] [187117] (4 PDB entries)
    11. 2111203Species Escherichia coli [TaxId:83333] [272301] (1 PDB entry)
    12. 2111206Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [189700] (1 PDB entry)
    13. 2111209Species Human (Homo sapiens) [TaxId:9606] [186768] (152 PDB entries)
    14. 2111463Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [189514] (1 PDB entry)
    15. 2111465Species Mouse (Mus musculus) [TaxId:10090] [186896] (12 PDB entries)
    16. 2111482Species Norway rat (Rattus norvegicus) [TaxId:10116] [194536] (6 PDB entries)
    17. 2111492Species Oryza sativa [TaxId:39947] [259129] (1 PDB entry)
    18. 2111494Species Pea (Pisum sativum) [TaxId:3888] [188398] (1 PDB entry)
    19. 2111503Species Plasmodium falciparum [TaxId:36329] [188290] (1 PDB entry)
    20. 2111509Species Pyrococcus horikoshii OT3 [TaxId:70601] [187582] (1 PDB entry)
    21. 2111512Species Saccharomyces cerevisiae [TaxId:764097] [261066] (1 PDB entry)
    22. 2111514Species Sulfolobus solfataricus [TaxId:2287] [255781] (5 PDB entries)
    23. 2111527Species Sulfolobus solfataricus [TaxId:273057] [256083] (12 PDB entries)
    24. 2111540Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [188355] (9 PDB entries)
    25. 2111554Species Thermus aquaticus [TaxId:271] [254880] (1 PDB entry)
    26. 2111558Species Thermus thermophilus HB8 [TaxId:300852] [255082] (2 PDB entries)
    27. 2111561Species Thermus thermophilus [TaxId:274] [256283] (6 PDB entries)
    28. 2285746Species Candida albicans [TaxId:237561] [329047] (1 PDB entry)

More info for Family c.37.1.8: G proteins

Timeline for Family c.37.1.8: G proteins: